Chih-Wei Chang

Department of Radiation Oncology
Assistant Professor

chih-wei.chang@emory.edu

Overview

Chih-Wei Chang, PhD, is an assistant professor and medical physicist in the Department of Radiation Oncology at Emory University School of Medicine.

Dr. Chang earned his PhD in nuclear engineering at North Carolina State University in Raleigh, North Carolina. He obtained his MS and BS in nuclear engineering and engineering and system science at the National Tsing Hua University in Hsinchu, Taiwan. He completed his medical physics residency with the Department of Radiation Oncology at Emory University School of Medicine in Atlanta, Georgia.

Dr. Chang's research interests include multidisciplinary approaches integrating state-of-the-art techniques, especially AI, to solve real-world challenges for radiation oncology and medical physics using GAI, physics-informed machine learning, digital-twin for online adaptive radiotherapy, and LLM-based clinical safety decision-making. He has been instrumental in formulating the physics-informed machine learning framework for nuclear system thermal-hydraulic simulation using partial differential equations. During his medical physics residency training at Emory University, He adapted this data-driven framework to enable CT-material characterization to improve proton range uncertainty and unsupervised deep learning-based CT metal artifact reduction.

Dr. Chang also devised a standardized commissioning framework for Monte Carlo-based treatment planning systems, which he applied to assess beam model uncertainties attributed to vendor upgrades and CT stoichiometric calibrations at Emory. This framework was also adopted by AAPM Task Group No. 349 - Commissioning of Monte Carlo Dose Calculation in Proton Therapy.

Academic Appointment

Assistant Professor, Department of Radiation Oncology, Emory University School of Medicine

Education

Degrees

PhD from North Carolina State University
MS from National Tsing Hua University
BS from National Tsing Hua University

Research

Publications

Data-Driven Volumetric Computed Tomography Image Generation From Surface Structures Using a Patient-Specific Deep Leaning Model.
Int J Radiat Oncol Biol Phys Volume: 121 Page(s): 1349 - 1360
04/01/2025 Authors: Pan S; Chang C-W; Tian Z; Wang T; Axente M; Shelton J; Liu T; Roper J; Yang X
Triad: Vision Foundation Model for 3D Magnetic Resonance Imaging

03/10/2025 Authors: Yang X; Wang S; Safari M; Li Q; Chang C-W; Qiu R; Roper J; Yu D
Exploration of an adaptive proton therapy strategy using CBCT with the concept of digital twins.
Phys Med Biol Volume: 70
01/17/2025 Authors: Chang C-W; Tian Z; Qiu RLJ; Scott Mcginnis H; Bohannon D; Patel P; Wang Y; Yu DS; Patel SA; Zhou J
Using a patient-specific diffusion model to generate CBCT-based synthetic CTs for CBCT-guided adaptive radiotherapy.
Med Phys Volume: 52 Page(s): 471 - 480
01/01/2025 Authors: Chen X; Qiu RLJ; Wang T; Chang C-W; Chen X; Shelton JW; Kesarwala AH; Yang X
Unsupervised Bayesian generation of synthetic CT from CBCT using patient-specific score-based prior.
Med Phys
12/12/2024 Authors: Peng J; Gao Y; Chang C-W; Qiu R; Wang T; Kesarwala A; Yang K; Scott J; Yu D; Yang X
CBCT-based synthetic CT image generation using a diffusion model for CBCT-guided lung radiotherapy.
Med Phys Volume: 51 Page(s): 8168 - 8178
11/01/2024 Authors: Chen X; Qiu RLJ; Peng J; Shelton JW; Chang C-W; Yang X; Kesarwala AH
Deep Learning-Based Fast Volumetric Image Generation for Image-Guided Proton Radiotherapy
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES Volume: 8 Page(s): 973 - 983
11/01/2024 Authors: Chang C-W; Lei Y; Wang T; Tian S; Roper J; Lin L; Bradley J; Liu T; Zhou J; Yang X
Artificial intelligence-based motion tracking in cancer radiotherapy: A review.
J Appl Clin Med Phys Volume: 25 Page(s): e14500
11/01/2024 Authors: Salari E; Wang J; Wynne JF; Chang C-W; Wu Y; Yang X
Exploring dual energy CT synthesis in CBCT-based adaptive radiotherapy and proton therapy: application of denoising diffusion probabilistic models.
Phys Med Biol Volume: 69
10/18/2024 Authors: Viar-Hernandez D; Manuel Molina-Maza J; Pan S; Salari E; Chang C-W; Eidex Z; Zhou J; Antonio Vera-Sanchez J; Rodriguez-Vila B; Malpica N
An LLM-Based Framework for Zero-Shot De-Identifying Flexible Text Data in Protected Health Information Enabling Potential Risk-Informed Patient Safety
Volume: 120 Page(s): E518 - E518
10/01/2024 Authors: Chang CW; Hu M; Ghavidel B; Wynne JF; Qiu RLJ; Washington M; Kayode O; Chin WG; Yang K; Scott JG
Real-Time Onboard Volumetric Imaging for Tumor Tracking during Treatment and Post-Treatment Dose Verification
Volume: 120 Page(s): S193 - S194
10/01/2024 Authors: Yang X; Pan S; Chang CW; Peng J; Qiu RLJ; Wang T; Liu T; Roper JR; Al-Hallaq H; Tian Z
Can Proton Prostate Treatment Margin be Further Reduced: Integrating Gaussian Process Prediction with Water Equivalent Thickness Mapping (GPP-WET-MAP) for the Management of Patient Specific Systematic Setup Error and Inter-Fraction Motion
Volume: 51 Page(s): 7756 - 7756
10/01/2024 Authors: Bohannon DH; Chang CW; Wang Y; Yang X; Patel P; Patel S; Zhou J
Synthetic Virtual Monoenergetic Images Based on Single-Energy CT Via Deep Learning Method
Volume: 51 Page(s): 7752 - 7752
10/01/2024 Authors: Gao Y; Xie H; Chang CW; Qiu RLJ; Roper JR; Yu D; Ghavidel BB; Patel P; Zhou J; Yang X
Integrating Deep and Hand-Crafted MRI Radiomics Features for Early Response Prediction of Gliomas
Volume: 51 Page(s): 7787 - 7787
10/01/2024 Authors: Salari E; Chen X; Jacob W; Chang CW; Qiu RLJ; Roper JR; Shu HK; Yang X
Source Model Parameters for Beam Commissioning of Scanning Proton Therapy Treatment Planning System: Multi-Institutional Survey and Analysis
Volume: 51 Page(s): 7693 - 7693
10/01/2024 Authors: Charyyev S; Chang CW; Lin L; Dong L; Li H; Schuemann JP; Shen J; Ding X
Image-domain material decomposition for dual-energy CT using unsupervised learning with data-fidelity loss.
Med Phys Volume: 51 Page(s): 6185 - 6195
09/01/2024 Authors: Peng J; Chang C-W; Xie H; Qiu RLJ; Roper J; Wang T; Ghavidel B; Tang X; Yang X
CT-based synthetic iodine map generation using conditional denoising diffusion probabilistic model.
Med Phys Volume: 51 Page(s): 6246 - 6258
09/01/2024 Authors: Gao Y; Xie H; Chang C-W; Peng J; Pan S; Qiu RLJ; Wang T; Ghavidel B; Roper J; Zhou J
Experimental study of high-mode buckling behavior of flat steel core in a-restrained brace
ENGINEERING STRUCTURES Volume: 314
09/01/2024 Authors: Lin P-C; Chang C-W; Wu B-C
CT-based synthetic contrast-enhanced dual-energy CT generation using conditional denoising diffusion probabilistic model.
Phys Med Biol Volume: 69
08/02/2024 Authors: Gao Y; Qiu RLJ; Xie H; Chang C-W; Wang T; Ghavidel B; Roper J; Zhou J; Yang X
Full-dose whole-body PET synthesis from low-dose PET using high-efficiency denoising diffusion probabilistic model: PET consistency model.
Med Phys Volume: 51 Page(s): 5468 - 5478
08/01/2024 Authors: Pan S; Abouei E; Peng J; Qian J; Wynne JF; Wang T; Chang C-W; Roper J; Nye JA; Mao H
MRI-based prostate cancer classification using 3D efficient capsule network.
Med Phys Volume: 51 Page(s): 4748 - 4758
07/01/2024 Authors: Li Y; Wynne J; Wang J; Roper J; Chang C-W; Patel AB; Shelton J; Liu T; Mao H; Yang X
Author Correction: MRI-only based material mass density and relative stopping power estimation via deep learning for proton therapy: a preliminary study.
Sci Rep Volume: 14 Page(s): 14647
06/25/2024 Authors: Gao Y; Chang C-W; Mandava S; Marants R; Scholey JE; Goette M; Lei Y; Mao H; Bradley JD; Liu T
Unsupervised Bayesian Generation of Synthetic CT from CBCT Using Patient-Specific Score-Based Prior

06/21/2024 Authors: Peng J; Gao Y; Chang C-W; Qiu R; Wang T; Kesarwala A; Yang K; Scott J; Yu D; Yang X
Unsupervised Bayesian Generation of Synthetic CT from CBCT Using Patient-Specific Score-Based Prior.

06/21/2024 Authors: Peng J; Gao Y; Chang C-W; Qiu R; Wang T; Kesarwala A; Yang K; Scott J; Yu D; Yang X
Unsupervised MRI motion artifact disentanglement: introducing MAUDGAN.
Phys Med Biol Volume: 69
05/30/2024 Authors: Safari M; Yang X; Chang C-W; Qiu RLJ; Fatemi A; Archambault L
Adaptive Proton Therapy Using CBCT-Guided Digital Twins

05/16/2024 Authors: Chang C-W; Tian Z; Qiu RLJ; McGinnis HS; Bohannon D; Patel P; Wang Y; Yu DS; Patel SA; Zhou J
MRI-only based material mass density and relative stopping power estimation via deep learning for proton therapy: a preliminary study.
Sci Rep Volume: 14 Page(s): 11166
05/15/2024 Authors: Gao Y; Chang C-W; Mandava S; Marants R; Scholey JE; Goette M; Lei Y; Mao H; Bradley JD; Liu T
A retrospective study on the investigation of potential dosimetric benefits of online adaptive proton therapy for head and neck cancer.
J Appl Clin Med Phys Volume: 25 Page(s): e14308
05/01/2024 Authors: Chang C-W; Bohannon D; Tian Z; Wang Y; Mcdonald MW; Yu DS; Liu T; Zhou J; Yang X
Fast MRI Reconstruction Using Deep Learning-based Compressed Sensing: A Systematic Review.

04/30/2024 Authors: Safari M; Eidex Z; Chang C-W; Qiu RLJ; Yang X
Synthetic CT generation from MRI using 3D transformer-based denoising diffusion model.
Med Phys Volume: 51 Page(s): 2538 - 2548
04/01/2024 Authors: Pan S; Abouei E; Wynne J; Chang C-W; Wang T; Qiu RLJ; Li Y; Peng J; Roper J; Patel P
Streamlined pin-ridge-filter design for single-energy proton FLASH planning.
Med Phys Volume: 51 Page(s): 2955 - 2966
04/01/2024 Authors: Ma C; Zhou J; Chang C-W; Wang Y; Patel PR; Yu DS; Tian S; Yang X
CBCT-Based synthetic CT image generation using conditional denoising diffusion probabilistic model.
Med Phys Volume: 51 Page(s): 1847 - 1859
03/01/2024 Authors: Peng J; Qiu RLJ; Wynne JF; Chang C-W; Pan S; Wang T; Roper J; Liu T; Patel PR; Yu DS
Robust explanation supervision for false positive reduction in pulmonary nodule detection.
Med Phys Volume: 51 Page(s): 1687 - 1701
03/01/2024 Authors: Zhao Q; Chang C-W; Yang X; Zhao L
High-resolution MRI synthesis using a data-driven framework with denoising diffusion probabilistic modeling.
Phys Med Biol Volume: 69
02/05/2024 Authors: Chang C-W; Peng J; Safari M; Salari E; Pan S; Roper J; Qiu RLJ; Gao Y; Shu H-K; Mao H
Deep learning-based synthetic dose-weighted LET map generation for intensity modulated proton therapy.
Phys Med Biol Volume: 69
01/05/2024 Authors: Gao Y; Chang C-W; Pan S; Peng J; Ma C; Patel P; Roper J; Zhou J; Yang X
Surface-based volumetric image reconstruction for image-guided procedures using a data-driven framework
Volume: 12928
01/01/2024 Authors: Chang CW; Pan S; Tian Z; Wang T; Axente M; Shelton J; Liu T; Roper J; Yang X
Explainable AI for Lung Nodule Detection and Classification in CT Images
Volume: 12927
01/01/2024 Authors: Chang CW; Zhao Q; Zhao L; Yang X
Synthetic CT Generation from MRI Using 3D Improved Diffusion Model
Volume: 12926
01/01/2024 Authors: Pan S; Abouei E; Wynne J; Wang T; Qiu RLJ; Li Y; Chang CW; Peng J; Qiu S; Roper J
Iodine Map Synthesis from Non-contrast CT Using Diffusion Model
Volume: 12925
01/01/2024 Authors: Gao Y; Xie H; Chang CW; Peng J; Qiu R; Wang T; Roper J; Ghavidel B; Zhou J; Yang X
Diffusion Model-based Single-scan Dual-energy Cone-beam CT Using Primary Beam Splitting
Volume: 12925
01/01/2024 Authors: Peng J; Chang CW; Qiu RLJ; Roper J; Wang T; Patel PR; Yu DS; Tang X; Yang X
Unsupervised-Learning Material Decomposition for Dual-Energy CT with Image-Domain Data Fidelity
Volume: 12925
01/01/2024 Authors: Peng J; Xie H; Chang CW; Roper J; Qiu RLJ; Wang T; Tang X; Yang X
Metal Artifact Reduction in CT Using Unsupervised Sinogram Manifold Learning
Volume: 12925
01/01/2024 Authors: Peng J; Chang CW; Xie H; Fan M; Wang T; Roper J; Qiu RLJ; Tang X; Yang X
Deep learning-assisted lesion segmentation in PET/CT imaging: A feasibility study for salvage radiation therapy in prostate cancer.
Oncoscience Volume: 11 Page(s): 49 - 50
01/01/2024 Authors: Qiu RLJ; Chang C-W; Yang X
Patient-specific 3D Volumetric CBCT Image Reconstruction with Single X-ray Projection Using Denoising Diffusion Probabilistic Model
Volume: 12931
01/01/2024 Authors: Pan S; Lo S-Y; Chang C-W; Salari E; Wang T; Roper J; Kesarwala AH; Yang X
Multimodal imaging-based material mass density estimation for proton therapy using supervised deep learning.
Br J Radiol Volume: 96 Page(s): 20220907
12/01/2023 Authors: Chang C-W; Marants R; Gao Y; Goette M; Scholey JE; Bradley JD; Liu T; Zhou J; Sudhyadhom A; Yang X
A spot-specific range uncertainty framework for robust optimization of proton therapy treatments.
Med Phys Volume: 50 Page(s): 6554 - 6568
10/01/2023 Authors: Cohilis M; Souris K; Buti G; Chang C-W; Lin L; Lee JA; Sterpin E
Estimating Potential Benefits of Online Adaptive Proton Therapy for Head-and-Neck Cancer: A Retrospective Study
Volume: 117 Page(s): E649 - E649
10/01/2023 Authors: Chang CW; Bohannon D; Tian Z; Wang Y; McDonald MW; Yu DS; Liu T; Zhou J; Yang X
Using Longitudinal MRI to Manage Proton Range Uncertainty for Pediatric Proton Craniospinal Irradiation
Volume: 117 Page(s): E505 - E506
10/01/2023 Authors: Chang CW; Goette M; Kadom N; Wang Y; Wynne JF; Wang T; Liu T; Esiashvili N; Zhou J; Eaton BR
An optimized framework for cone-beam computed tomography-based online evaluation for proton therapy.
Med Phys Volume: 50 Page(s): 5375 - 5386
09/01/2023 Authors: Chang C-W; Nilsson R; Andersson S; Bohannon D; Patel SA; Patel PR; Liu T; Yang X; Zhou J
Deep learning-based Fast Volumetric Image Generation for Image-guided Proton FLASH Radiotherapy.

07/26/2023 Authors: Chang C-W; Lei Y; Wang T; Tian S; Roper J; Lin L; Bradley J; Liu T; Zhou J; Yang X
Streamlined Pin-Ridge-Filter Design for Single-energy Proton FLASH Planning

06/21/2023 Authors: Ma C; Zhou J; Chang C-W; Wang Y; Patel PR; Yu DS; Tian S; Yang X
Feasibility study of hybrid inverse planning with transmission beams and single-energy spread-out Bragg peaks for proton FLASH radiotherapy.
Med Phys Volume: 50 Page(s): 3687 - 3700
06/01/2023 Authors: Ma C; Yang X; Chang C-W; Liu R; Bohannon D; Lin L; Liu T; Tian S; Zhou J
Prediction of plan adaptation in head and neck cancer proton therapy using clinical, radiographic, and dosimetric features.
Acta Oncol Volume: 62 Page(s): 627 - 634
06/01/2023 Authors: Bohannon D; Janopaul-Naylor J; Rudra S; Yang X; Chang CW; Wang Y; Ma C; Patel SA; McDonald MW; Zhou J
Feasibility study of hybrid inverse planning with transmission beams and singleenergy spreadout Bragg peaks for proton FLASH radiotherapy
Medical Physics Volume: 50 Page(s): 3687 - 3700
06/01/2023 Authors: Ma C; Yang X; Chang C; Liu R; Bohannon D; Lin L; Liu T; Tian S; Zhou J
2D medical image synthesis using transformer-based denoising diffusion probabilistic model
Physics in Medicine & Biology Volume: 68 Page(s): 105004 - 105004
05/21/2023 Authors: Pan S; Wang T; Qiu RLJ; Axente M; Chang C-W; Peng J; Patel AB; Shelton J; Patel SA; Roper J
2D medical image synthesis using transformer-based denoising diffusion probabilistic model.
Phys Med Biol Volume: 68
05/05/2023 Authors: Pan S; Wang T; Qiu RLJ; Axente M; Chang C-W; Peng J; Patel AB; Shelton J; Patel SA; Roper J
Data-Driven Volumetric Image Generation from Surface Structures using a Patient-Specific Deep Leaning Model.

05/02/2023 Authors: Pan S; Chang C-W; Axente M; Wang T; Shelton J; Liu T; Roper J; Yang X
Abdomen CT multi-organ segmentation using token-based MLP-Mixer.
Med Phys Volume: 50 Page(s): 3027 - 3038
05/01/2023 Authors: Pan S; Chang C-W; Wang T; Wynne J; Hu M; Lei Y; Liu T; Patel P; Roper J; Yang X
Abdomen CT multiorgan segmentation using tokenbased MLPMixer
Medical Physics Volume: 50 Page(s): 3027 - 3038
05/01/2023 Authors: Pan S; Chang C; Wang T; Wynne J; Hu M; Lei Y; Liu T; Patel P; Roper J; Yang X
A component method to delineate surgical spine implants for proton Monte Carlo dose calculation.
J Appl Clin Med Phys Volume: 24 Page(s): e13800
01/01/2023 Authors: Chang C-W; Charyyev S; Harms J; Slopsema R; Wolf J; Refai D; Yoon T; McDonald MW; Bradley JD; Leng S
Characterization of 250 MeV Protons from the Varian ProBeam PBS System for FLASH Radiation Therapy.
Int J Part Ther Volume: 9 Page(s): 279 - 289
01/01/2023 Authors: Charyyev S; Chang C-W; Zhu M; Lin L; Langen K; Dhabaan A
In vivo proton range validation using pseudo proton radiography
Volume: 12463
01/01/2023 Authors: Chang CW; Zhou S; Gao Y; Lin L; Liu T; Bradley JD; Zhang T; Zhou J; Yang X
Early in vivo Radiation Damage Quantification for Pediatric Craniospinal Irradiation Using Longitudinal MRI for Intensity Modulated Proton Therapy.
Adv Radiat Oncol Volume: 8 Page(s): 101267
01/01/2023 Authors: Chang C-W; Goette M; Kadom N; Wang Y; Wynne J; Wang T; Liu T; Esiashvili N; Zhou J; Eaton BR
Ultrasound Breast Tumor Detection based on Vision Graph Neural Network
Volume: 12470
01/01/2023 Authors: Hu M; Wang J; Chang CW; Liu T; Yang X
Physics-informed multi-modal imaging-based material characterization for proton therapy
Volume: 12463
01/01/2023 Authors: Chang CW; Marants R; Gao Y; Goette M; Scholey JE; Bradley JD; Liu T; Zhou J; Sudhyadhom A; Yang X
Mass density estimation based on single-energy computed tomography via deep learning
Volume: 12463
01/01/2023 Authors: Gao Y; Chang CW; Pan S; Lei Y; Wang T; Zhou J; Bradley JD; Liu T; Yang X
Multi-parametric MRI radiomics analysis with ensemble learning for prostate lesion classification
Volume: 12468
01/01/2023 Authors: Li Y; Wang J; Chang CW; Patel P; Jani A; Mao H; Liu T; Yang X
End-to-end brain tumor detection using a graph-feature-based classifier
Volume: 12468
01/01/2023 Authors: Hu M; Wang J; Chang CW; Liu T; Yang X
Quantification of radiation damage for proton craniospinal irradiation using magnetic resonance imaging
Volume: 12468
01/01/2023 Authors: Chang CW; Goette M; Kadom N; Wang Y; Wynne J; Wang T; Liu T; Esiashvili N; Zhou J; Eaton BR
Multi-structure segmentation on cardiac MRI using multilayer perceptron mixer network
Volume: 12468
01/01/2023 Authors: Pan S; Ma C; Chang CW; Wynne J; Roper J; Liu T; Yang X
Single energy CT-based mass density and relative stopping power estimation for proton therapy using deep learning method.
Front Oncol Volume: 13 Page(s): 1278180
01/01/2023 Authors: Gao Y; Chang C-W; Roper J; Axente M; Lei Y; Pan S; Bradley JD; Zhou J; Liu T; Yang X
A component method to delineate surgical spine implants for proton Monte Carlo dose calculation
Journal of Applied Clinical Medical Physics Volume: 24
01/01/2023 Authors: Chang C; Charyyev S; Harms J; Slopsema R; Wolf J; Refai D; Yoon T; McDonald MW; Bradley JD; Leng S
Validation of a deep learning-based material estimation model for Monte Carlo dose calculation in proton therapy
Physics in Medicine & Biology Volume: 67 Page(s): 215004 - 215004
11/07/2022 Authors: Chang C-W; Zhou S; Gao Y; Lin L; Liu T; Bradley JD; Zhang T; Zhou J; Yang X
A Retrospective Study on the Investigation of Potential Clinical Benefits of Online Adaptive Proton Therapy for Head and Neck Cancer

11/03/2022 Authors: Chang C-W; Bohannon D; Tian Z; Wang Y; Mcdonald MW; Yu DS; Liu T; Zhou J; Yang X
Early in vivo Radiation Damage Quantification for Pediatric Craniospinal Irradiation Using Longitudinal MRI for Intensity Modulated Proton Therapy

10/27/2022 Authors: Chang C-W; Goette M; Kadom N; Wang Y; Wynne J; Wang T; Liu T; Esiashvili N; Zhou J; Eaton BR
Validation of a deep learning-based material estimation model for Monte Carlo dose calculation in proton therapy.
Phys Med Biol Volume: 67
10/19/2022 Authors: Chang C-W; Zhou S; Gao Y; Lin L; Liu T; Bradley JD; Zhang T; Zhou J; Yang X
Male pelvic multi-organ segmentation using token-based transformer Vnet.
Phys Med Biol Volume: 67
10/14/2022 Authors: Pan S; Lei Y; Wang T; Wynne J; Chang C-W; Roper J; Jani AB; Patel P; Bradley JD; Liu T
MRI-based Material Mass Density and Relative Stopping Power Estimation via Deep Learning for Proton Therapy

10/11/2022 Authors: Gao Y; Chang C-W; Mandava S; Marants R; Scholey JE; Goette M; Lei Y; Mao H; Bradley JD; Liu T
Deep learning-based Fast Volumetric Image Generation for Image-guided Proton FLASH Radiotherapy

10/03/2022 Authors: Chang C-W; Lei Y; Wang T; Tian S; Roper J; Lin L; Bradley J; Liu T; Zhou J; Yang X
A potential revolution in cancer treatment: A topical review of FLASH radiotherapy.
J Appl Clin Med Phys Volume: 23 Page(s): e13790
10/01/2022 Authors: Gao Y; Liu R; Chang C-W; Charyyev S; Zhou J; Bradley JD; Liu T; Yang X
A potential revolution in cancer treatment: A topical review of FLASH radiotherapy
Journal of Applied Clinical Medical Physics Volume: 23
10/01/2022 Authors: Gao Y; Liu R; Chang C; Charyyev S; Zhou J; Bradley JD; Liu T; Yang X
A multi-layer strip ionization chamber (MLSIC) device for proton pencil beam scan quality assurance.
Phys Med Biol Volume: 67
08/23/2022 Authors: Zhou S; Rao W; Chen Q; Tan Y; Smith W; Sun B; Zhou J; Chang C-W; Lin L; Darafsheh A
Multimodal Imaging-based Material Mass Density Estimation for Proton Therapy Using Physics-Constrained Deep Learning

07/26/2022 Authors: Chang C-W; Marants R; Gao Y; Goette M; Scholey JE; Bradley JD; Liu T; Zhou J; Sudhyadhom A; Yang X
Dual-energy CT based mass density and relative stopping power estimation for proton therapy using physics-informed deep learning
Physics in Medicine & Biology Volume: 67 Page(s): 115010 - 115010
06/07/2022 Authors: Chang C-W; Gao Y; Wang T; Lei Y; Wang Q; Pan S; Sudhyadhom A; Bradley JD; Liu T; Lin L
Validation of a CBCT-Based Online Evaluation Workflow for Proton Therapy
Volume: 49 Page(s): E871 - E871
06/01/2022 Authors: Chang C; Nilsson R; Andersson S; Bohannon D; Lin L; Patel S; Patel P; Langen K; Bradley J; Liu T
Multi-Domain Constraint Based Estimation of Effective Atomic Number and Electron Density for Dual Energy CT
Volume: 49 Page(s): E124 - E125
06/01/2022 Authors: Wang Q; Xie H; Chang C; Wang T; Roper J; Tang X; Bradley J; Liu T; Yang X
Realtime Volumetric Image for Target Localization During Proton FLASH Radiotherapy
Volume: 49 Page(s): E489 - E489
06/01/2022 Authors: Chang C; Lei Y; Wang T; Zhou J; Lin L; Roper J; Higgins K; Liu T; Bradley J; Yang X
DECT-Based Material Mass Density Mapping for Proton Monte Carlo Dose Calculation Using Physics-Informed Deep Learning
Volume: 49 Page(s): E526 - E527
06/01/2022 Authors: Chang C; Gao Y; Wang T; Lei Y; Wang Q; Bradley J; Liu T; Lin L; Zhou J; Yang X
Physics-Informed Deep Learning for Accurate Material Density Map Generation Using MRI and DECT
Volume: 49 Page(s): E499 - E499
06/01/2022 Authors: Chang C; Marants R; Gao Y; Goette M; Scholey J; Bradley J; Liu T; Zhou J; Sudhyadhom A; Yang X
Predictive Maintenance Model for Early Detection of Plan Adaptation in Proton Head and Neck Treatment
Volume: 49 Page(s): E710 - E710
06/01/2022 Authors: Bohannon D; Chang C; Janopaul-naylor J; Ma C; Diamond Z; Lin L; Bradley J; Liu T; Yang X; McDonald M
Dual-energy CT based mass density and relative stopping power estimation for proton therapy using physics-informed deep learning.
Phys Med Biol Volume: 67
05/26/2022 Authors: Chang C-W; Gao Y; Wang T; Lei Y; Wang Q; Pan S; Sudhyadhom A; Bradley JD; Liu T; Lin L
Onboard cone-beam CT-based replan evaluation for head and neck proton therapy.
J Appl Clin Med Phys Volume: 23 Page(s): e13550
05/01/2022 Authors: Stanforth A; Lin L; Beitler JJ; Janopaul-Naylor JR; Chang C-W; Press RH; Patel SA; Zhao J; Eaton B; Schreibmann EE
A deep learning approach to transform two orthogonal X-ray images to volumetric images for image-guided proton therapy
Page(s): 61 - 61
04/04/2022 Authors: Chang C-W; Lei Y; Wang T; Zhou J; Lin L; Bradley JD; Liu T; Yang X
Using a neural network to enhance dual-energy computed tomography parametric mapping for proton therapy
Page(s): 154 - 154
04/04/2022 Authors: Chang C-W; Gao Y; Wang Q; Lei Y; Wang T; Zhou J; Lin L; Bradley JD; Liu T; Yang X
Using orthogonal 2D kV images for target localization via central matching networks
Page(s): 64 - 64
04/04/2022 Authors: Chang C-W; Lei Y; Wang T; Lin L; Zhou J; Bradley JD; Liu T; Yang X
Dosimetric Uncertainties in Dominant Intraprostatic Lesion Simultaneous Boost Using Intensity Modulated Proton Therapy.
Adv Radiat Oncol Volume: 7 Page(s): 100826
01/01/2022 Authors: Zhou J; Yang X; Chang C-W; Tian S; Wang T; Lin L; Wang Y; Janopaul-Naylor JR; Patel P; Demoor JD
Using a neural network to enhance dual-energy computed tomography parametric mapping for proton therapy
Volume: 12031
01/01/2022 Authors: Chang CW; Gao Y; Wang Q; Lei Y; Wang T; Zhou J; Lin L; Bradley JD; Liu T; Yang X
Using orthogonal 2D kV images for target localization via central matching networks
Volume: 12034
01/01/2022 Authors: Chang CW; Lei Y; Wang T; Lin L; Zhou J; Bradley JD; Liu T; Yang X
A Deep Learning Approach to Transform Two Orthogonal X-Ray Images to Volumetric Images for Image-guided Proton Therapy
Volume: 12032
01/01/2022 Authors: Chang CW; Lei Y; Wang T; Zhou J; Lin L; Bradley JD; Liu T; Yang X
An unsupervised patient-specific metal artifact reduction framework for proton therapy
Volume: 12034
01/01/2022 Authors: Chang CW; Lei Y; Charyyev S; Leng S; Yoon T; Zhou J; Yang X; Lin L
Dosimetric Uncertainties in Dominant Intraprostatic Lesion Simultaneous Boost Using Intensity Modulated Proton Therapy
Advances in Radiation Oncology Volume: 7 Page(s): 100826 - 100826
01/01/2022 Authors: Zhou J; Yang X; Chang C-W; Tian S; Wang T; Lin L; Wang Y; Janopaul-Naylor JR; Patel P; Demoor JD
Robust Optimization of Proton Therapy Treatments Using a Variable Range Uncertainty
Volume: 48
06/01/2021 Authors: Cohilis M; Sterpin E; Chang C; Rivas S; Lin L; Lee J; Souris K
A Novel Component Method to Delineate Surgical Spine Implants for Proton Monte Carlo Dose Calculation
Volume: 48
06/01/2021 Authors: Chang C; Charyyev S; Harms J; Slopsema R; Wolf J; Refai D; Yoon T; McDonald M; Bradley J; Leng S
A novel proton counting detector and method for the validation of tissue and implant material maps for Monte Carlo dose calculation.
Phys Med Biol Volume: 66 Page(s): 045003
02/02/2021 Authors: Charyyev S; Chang C-W; Harms J; Oancea C; Yoon ST; Yang X; Zhang T; Zhou J; Lin L
Commissioning of GPUAccelerated Monte Carlo Code FRED for Clinical Applications in Proton Therapy
Frontiers in Physics Volume: 8
01/21/2021 Authors: Gajewski J; Garbacz M; Chang CW; Czerska K; Durante M; Krah N; Krzempek K; Kope R; Lin L; Mojeszek N
Accurate characterization of metal implants and human materials using novel proton counting detector for monte carlo dose calculation in proton therapy
Volume: 11595
01/01/2021 Authors: Charyyev S; Chang CW; Harms J; Oancea C; Yoon ST; Yang X; Zhang T; Zhou J; Leng S; Lin L
Online Prediction of Dosimetric Changes in Dominant Intraprostatic Lesion Simultaneous Boost Using Intensity Modulated Proton Therapy
Volume: 108 Page(s): S170 - S171
11/01/2020 Authors: Zhou J; Tian S; Patel SA; Janopaul-Naylor J; Chang CW; Lin L; Jung J; Bohannon D; Demoor J; Godette KD
Reynolds-Averaged Turbulence Modeling Using Deep Learning with Local Flow Features: An Empirical Approach
Nuclear Science and Engineering Volume: 194 Page(s): 650 - 664
09/01/2020 Authors: Chang CW; Fang J; Dinh NT
Optimization of hexagonal-pattern minibeams for spatially fractionated radiotherapy using proton beam scanning.
Med Phys Volume: 47 Page(s): 3485 - 3495
08/01/2020 Authors: Charyyev S; Artz M; Szalkowski G; Chang C-W; Stanforth A; Lin L; Zhang R; Wang C-KC
Prediction of Dosimetric Variation in Dominant Intraprostatic Lesion with Simultaneous Integrated Boost for Pencil Beam Proton Therapy
Volume: 47 Page(s): E434 - E434
06/01/2020 Authors: Chang C; Bohannon D; Stiles K; Stanforth A; Tian S; Wang Y; Lin L; Patel P; Liu T; Yang X
Energy Layer Filtering and Splitting in Breath Sampled Re-Painting for Lung SBRT Using Pencil Beam Scanning Proton Beams
Volume: 47 Page(s): E764 - E765
06/01/2020 Authors: Stiles K; Chang C; Stanforth A; Wang Y; Demoor J; Higgins K; McDonald M; Bradley J; Liu T; Yang X
Voxel-Specific Characterization of An Anthropomorphic Phantom as the Ultimate Ground Truth to Evaluate the Accuracy of Various Imaging Methods of Proton Therapy
Volume: 47 Page(s): E880 - E880
06/01/2020 Authors: Chang C; Harms J; Charyyev S; Zhou J; Yang X; Lin L
Timing Features of 4D Detector and Pencil Beam Scanning Proton Therapy Can Improve WET Map Accuracy with Deep CNN
Volume: 47 Page(s): E866 - E866
06/01/2020 Authors: Chang C; Zhou S; Zhou J; Yang X; Zhang T; Lin L
Measurements of LET, Nuclear Halo, Energy and Angular Spectra of a Proton Spot Scanning Beam with a Hybrid Semiconductor Detector
Volume: 47 Page(s): E470 - E470
06/01/2020 Authors: Charyyev S; Chang C; Stanforth A; Harms J; Oancea C; Lin L
Derivation of Photon Cross Section Coefficients of Virtual Monoenergetic CT Images for Radiotherapy Treatment Planning
Volume: 47 Page(s): E599 - E599
06/01/2020 Authors: Harms J; Chang C; Charyyev S; Zhou J; Yang X; Lin L
A standardized commissioning framework of Monte Carlo dose calculation algorithms for proton pencil beam scanning treatment planning systems.
Med Phys Volume: 47 Page(s): 1545 - 1557
04/01/2020 Authors: Chang C-W; Huang S; Harms J; Zhou J; Zhang R; Dhabaan A; Slopsema R; Kang M; Liu T; McDonald M
Nuclear halo measurements for accurate prediction of field size factor in a Varian ProBeam proton PBS system.
J Appl Clin Med Phys Volume: 21 Page(s): 197 - 204
01/01/2020 Authors: Harms J; Chang C-W; Zhang R; Lin L
Pseudo Proton Radiography Beam Validation of Monte Carlo Dose Calculation in Two Pencil Beam Scanning Treatment Planning Systems
Volume: 46 Page(s): E592 - E592
06/01/2019 Authors: Chang C; Zhou J; Yang X; Dhabaan A; Zhang R; Liu T; McDonald M; Langen K; Lin L
A Golden Beam Data Commissioning Framework of Monte Carlo Dose Calculation Algorithms of Two Pencil Beam Scanning Proton Therapy Treatment Planning Systems
Volume: 46 Page(s): E167 - E167
06/01/2019 Authors: Chang C; Harms J; Zhang R; Zhou J; Lin Y; Slopsema R; Dhabaan A; Liu T; McDonald M; Langen K
Reynolds-averaged turbulence modeling using deep learning with local flow features
Page(s): 1698 - 1711
01/01/2019 Authors: Chang CW; Fang J; Dinh NT
Classification of machine learning frameworks for data-driven thermal fluid models
International Journal of Thermal Sciences Volume: 135 Page(s): 559 - 579
01/01/2019 Authors: Chang CW; Dinh NT
Reynolds-Averaged Turbulence Modeling Using Type I and Type II Machine Learning Frameworks with Deep Learning

04/03/2018 Authors: Chang C-W; Dinh NT
Classification of Machine Learning Frameworks for Data-Driven Thermal Fluid Models

01/19/2018 Authors: Chang C-W; Dinh NT
Physics-constrained machine learning for two-phase flow simulation using deep learning-based closure relation
Volume: 117 Page(s): 1749 - 1752
01/01/2017 Authors: Chang CW; Dinh N; Cetiner SM
A study of physics-informed deep learning for system fluid dynamics closures
Volume: 115 Page(s): 1785 - 1788
01/01/2016 Authors: Chang CW; Dinh N
Small modular reactor modeling using Modelica for nuclear-renewable hybrid energy systems applications
Volume: 113 Page(s): 903 - 906
01/01/2015 Authors: Mikkelson D; Chang CW; Cetiner SM; Lou Qualls A; Michael Doster J; Nam Dinh T
A scoping study of direct containment heating in a small modular reactor
Volume: 111 Page(s): 907 - 910
01/01/2014 Authors: Chang CW; Dinh N

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