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Profile

Andre Holder MD, MSc

  • Department of Medicine
    Associate Professor
  • andre.holder@emory.edu
Head shot of Andre Holder

Overview

Dr. Holder completed his undergraduate education at Cornell University and his medical school education and a combined residency in Emergency Medicine and Internal Medicine at the State University of New York Health Science Center at Brooklyn (SUNY Downstate).

After completing his residency, he practiced emergency medicine at Jacobi Medical Center, and completed his Masters of Science in Clinical Research Methodology at Albert Einstein College of Medicine in the Bronx, NY. He subsequently did a clinical fellowship in Critical Care Medicine and an NIH T32 research fellowship at the University of Pittsburgh from 2011-2014, working in their cardiopulmonary lab group under the mentorship of Drs. Michael Pinsky and Gilles Clermont. Upon completion of his fellowships, he was recruited by Dr. Guidot to join Emory faculty as an Assistant Professor. His clinical practice is exclusively at Grady Memorial Hospital.

Dr. Holders research has focused on understanding the progression of inflammatory diseases that cause critical illness, with a specific emphasis on sepsis pathophysiology. He is interested in employing advanced data-driven techniques such as nonlinear prediction modeling and machine learning approaches to predict the trajectory of complex syndromes like sepsis. Dr. Holder studies whether temporal trends in physiologic and laboratory biomarkers, and complex measures of physiologic variability can improve prediction of clinical deterioration in sepsis.

Dr. Holder is mentored by a multidisciplinary team which includes Drs. Greg Martin, Gari Clifford (Department of Biomedical Informatics), James Blum (Department of Anesthesia), and Timothy Buchman (Department of Surgery).

Academic Appointment

  • Assistant Professor, Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University

Education

Degrees

  • MD from SUNY Health Science Center at Brooklyn
  • MSc from Yeshiva University

Research

Focus

  • Predictive analytics in critical illness, hemodynamic monitoring, cardiopulmonary resuscitation

    Dr. Holder's research thus far has focused on understanding the progression of inflammatory diseases that cause critical illness, with a specific emphasis on sepsis pathophysiology. He is interested in employing advanced data-driven techniques such as nonlinear prediction modeling and machine learning approaches to predict the trajectory of complex syndromes like sepsis. Dr. Holder studies whether temporal trends in physiologic and laboratory biomarkers, and complex measures of physiologic variability can improve prediction of clinical deterioration in sepsis. He is mentored by a multidisciplinary team which includes Drs. Greg Martin, Gari Clifford (Department of Biomedical Informatics), and Timothy Buchman (Department of Surgery).

Publications

  • Can we predict the future of respiratory failure prediction?
    Crit Care Volume: 29 Page(s): 253
    06/19/2025 Authors: Pearce AK; Nemati S; Goligher EC; Hough CL; Holder AL; Wardi G; Yang P; Boussina A; Lyons PG; Sahetya S
  • Moderate IV Fluid Resuscitation Is Associated With Decreased Sepsis Mortality.
    Crit Care Med Volume: 52 Page(s): e557 - e567
    11/01/2024 Authors: Corl KA; Levy MM; Holder AL; Douglas IS; Linde-Zwirble WT; Alam A
  • Should AI models be explainable to clinicians?
    Crit Care Volume: 28 Page(s): 301
    09/12/2024 Authors: Abgrall G; Holder AL; Chelly Dagdia Z; Zeitouni K; Monnet X
  • The Precision Resuscitation With Crystalloids in Sepsis (PRECISE) Trial: A Trial Protocol.
    JAMA Netw Open Volume: 7 Page(s): e2434197
    09/03/2024 Authors: Bhavani SV; Holder A; Miltz D; Kamaleswaran R; Khan S; Easley K; Murphy DJ; Franks N; Wright DW; Kraft C
  • Racial Differences in Accuracy of Predictive Models for High-Flow Nasal Cannula Failure in COVID-19.
    Crit Care Explor Volume: 6 Page(s): e1059
    03/01/2024 Authors: Yang P; Gregory IA; Robichaux C; Holder AL; Martin GS; Esper AM; Kamaleswaran R; Gichoya JW; Bhavani SV
  • A Delphi Process to Identify Relevant Outcomes That May Be Associated With a Predictive Analytic Tool to Detect Hemodynamic Deterioration in the Intensive Care Unit.
    Cureus Volume: 15 Page(s): e50169
    12/01/2023 Authors: Holder AL; Khanna AK; Scott MJ; Rossetti SC; Rinehart JB; Linn DD; Weichert J; Dellinger RP
  • A MACHINE LEARNING MODEL DERIVED FROM ANALYSIS OF TIME-COURSE GENE-EXPRESSION DATASETS REVEALS TEMPORALLY STABLE GENE MARKERS PREDICTIVE OF SEPSIS MORTALITY.
    Shock Volume: 60 Page(s): 671 - 677
    11/01/2023 Authors: Huang M; Atreya MR; Holder A; Kamaleswaran R
  • HIRA: Heart Rate Interval based Rapid Alert score to characterize autonomic dysfunction among patients with sepsis-related acute respiratory failure (ARF).
    Physiol Meas Volume: 44
    10/13/2023 Authors: Krishnan P; Rad MG; Agarwal P; Marshall C; Yang P; Bhavani SV; Holder AL; Esper A; Kamaleswaran R
  • Facilitating the Next Paradigm Shift in Critical Care Through Artificial Intelligence.
    Crit Care Clin Volume: 39 Page(s): xiii - xiv
    10/01/2023 Authors: Holder AL; Kamaleswaran R
  • Overt and Occult Hypoxemia in Patients Hospitalized With COVID-19.
    Crit Care Explor Volume: 5 Page(s): e0825
    01/01/2023 Authors: Gadrey SM; Mohanty P; Haughey SP; Jacobsen BA; Dubester KJ; Webb KM; Kowalski RL; Dreicer JJ; Andris RT; Clark MT
  • Serial Measurements of Protein Biomarkers in Sepsis-Induced Acute Respiratory Distress Syndrome.
    Crit Care Explor Volume: 4 Page(s): e0780
    10/01/2022 Authors: Yang P; Iffrig E; Harris F; Holder AL; Martin GS; Esper AM
  • Overt and occult hypoxemia in patients hospitalized with novel coronavirus disease 2019.
    medRxiv
    06/16/2022 Authors: Gadrey SM; Mohanty P; Haughey SP; Jacobsen BA; Dubester KJ; Webb KM; Kowalski RL; Dreicer JJ; Andris RT; Clark MT
  • Leveraging clinical data across healthcare institutions for continual learning of predictive risk models.
    Sci Rep Volume: 12 Page(s): 8380
    05/19/2022 Authors: Amrollahi F; Shashikumar SP; Holder AL; Nemati S
  • Relationship of Dynamic Point-of-Care Assessment to Fluid Administration and Outcomes in Septic Shock
    Volume: 205
    05/01/2022 Authors: Holder A; Chen T; Wang T; Zheng Z; Zhang R; Austin N; Smith S; Sikora AN; Chen J
  • Initiation of Interventions for Cardiovascular and Respiratory Failure with Community-Acquired vs. Hospital-Acquired Sepsis
    Volume: 205
    05/01/2022 Authors: Kamal S; Esper AM; Martin GS; Chen T; Holder AL
  • The Big Consequences of Small Discrepancies: Why Racial Differences in Pulse Oximetry Errors Matter.
    Crit Care Med Volume: 50 Page(s): 335 - 337
    02/01/2022 Authors: Holder AL; Wong A-KI
  • Coronavirus Disease 2019 Temperature Trajectories Correlate With Hyperinflammatory and Hypercoagulable Subphenotypes.
    Crit Care Med Volume: 50 Page(s): 212 - 223
    02/01/2022 Authors: Bhavani SV; Verhoef PA; Maier CL; Robichaux C; Parker WF; Holder A; Kamaleswaran R; Wang MD; Churpek MM; Coopersmith CM
  • CHARACTERIZING FLUID AND VASOPRESSOR USE IN REDUCED EJECTION FRACTION: REANALYSIS OF VOLUME-CHASERS
    Volume: 50 Page(s): 692 - 692
    01/01/2022 Authors: Chase A; Smith S; Holder A; Newsome A
  • A Locally Optimized Data-Driven Tool to Predict Sepsis-Associated Vasopressor Use in the ICU.
    Crit Care Med Volume: 49 Page(s): e1196 - e1205
    12/01/2021 Authors: Holder AL; Shashikumar SP; Wardi G; Buchman TG; Nemati S
  • Analysis of Discrepancies Between Pulse Oximetry and Arterial Oxygen Saturation Measurements by Race and Ethnicity and Association With Organ Dysfunction and Mortality.
    JAMA Netw Open Volume: 4 Page(s): e2131674
    11/01/2021 Authors: Wong A-KI; Charpignon M; Kim H; Josef C; de Hond AAH; Fojas JJ; Tabaie A; Liu X; Mireles-Cabodevila E; Carvalho L
  • POST-ICTAL, AGITATED, AND TACHYCARDIC: A CAN'T MISS DIAGNOSIS AND A DISSECTION OF MULTI-ORGAN PHYSIOLOGY
    Volume: 36 Page(s): S255 - S255
    07/01/2021 Authors: Sadjadi R; Park JM; Runnstrom M; Holder A
  • Prediction of Acute Respiratory Failure Requiring Advanced Respiratory Support in Advance of Interventions and Treatment: A Multivariable Prediction Model From Electronic Medical Record Data.
    Crit Care Explor Volume: 3 Page(s): e0402
    05/01/2021 Authors: Wong A-KI; Kamaleswaran R; Tabaie A; Reyna MA; Josef C; Robichaux C; de Hond AAH; Steyerberg EW; Holder AL; Nemati S
  • Domain Adaptation for Robust Predictive Modeling Across Racial Groups
    Volume: 203
    05/01/2021 Authors: Shashikumar S; Josef C; Holder A; Malhotra A; Nemati S
  • Body Temperature Trajectory Associated with Venous Thromboembolism in COVID-19 Patients
    Volume: 203
    05/01/2021 Authors: Bhavani S; Holder A; Kamaleswaran R; Verhoef PA; Churpek MM; Wang M; Coopersmith C
  • Major publications in the critical care pharmacotherapy literature: 2019.
    J Crit Care Volume: 62 Page(s): 197 - 205
    04/01/2021 Authors: Condeni MS; Basting AT; Costello PG; DePriest A; Eriksson EA; Evans H; Hertel K; Holder AL; Kester AN; Kowalski KR
  • Predicting Progression to Septic Shock in the Emergency Department Using an Externally Generalizable Machine-Learning Algorithm.
    Ann Emerg Med Volume: 77 Page(s): 395 - 406
    04/01/2021 Authors: Wardi G; Carlile M; Holder A; Shashikumar S; Hayden SR; Nemati S
  • eARDS: A multi-center validation of an interpretable machine learning algorithm of early onset Acute Respiratory Distress Syndrome (ARDS) among critically ill adults with COVID-19.
    PLoS One Volume: 16 Page(s): e0257056
    01/01/2021 Authors: Singhal L; Garg Y; Yang P; Tabaie A; Wong AI; Mohammed A; Chinthala L; Kadaria D; Sodhi A; Holder AL
  • DYNAMIC ASSESSMENTS OF FLUID RESPONSIVENESS REDUCE EXCESS FLUID ADMINISTRATION
    Volume: 49 Page(s): 624 - 624
    01/01/2021 Authors: Douglas I; Alapat P; Corl K; Exline M; Forni L; Holder A; Kaufman D; Khan A; Levy M; Martin G
  • Fluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial.
    Chest Volume: 158 Page(s): 1431 - 1445
    10/01/2020 Authors: Douglas IS; Alapat PM; Corl KA; Exline MC; Forni LG; Holder AL; Kaufman DA; Khan A; Levy MM; Martin GS
  • Machine Learning Methods to Predict Acute Respiratory Failure and Acute Respiratory Distress Syndrome.
    Front Big Data Volume: 3 Page(s): 579774
    01/01/2020 Authors: Wong A-KI; Cheung PC; Kamaleswaran R; Martin GS; Holder AL
  • Preload Functional Status and Cardiac Output in Sepsis
    Volume: 201
    01/01/2020 Authors: Douglas IS; Alapat PM; Corl K; Exline MC; Forni L; Holder A; Kaufman DA; Khan A; Levy MM; Martin GS
  • The Independent Association of Mechanical Ventilation with Septic Shock Severity
    Volume: 201
    01/01/2020 Authors: Merchant A; Esper AM; Martin GS; Holder AL
  • Classification of Subsequent Acute Respiratory Failure (ARF) Requiring Prolonged Mechanical Ventilation by Basic Machine Learning Algorithms
    Volume: 201
    01/01/2020 Authors: Wong AI; Tabaie A; Holder AL; Reyna MA; Josef C; Robichaux C; Nemati S; Buchman T; Blum JM
  • Assessment of EMR Data Availability Within the First 12 Hours of Admission for Prediction by Machine Learning Methods
    Volume: 201
    01/01/2020 Authors: Wong AI; Tabaie A; Holder AL; Reyna M; Nemati S; Josef C; Robichaux C; Blum JM
  • FLUID RESPONSIVENESS AND DIURETIC USE IN PATIENTS WITH SEPTIC SHOCK
    Volume: 48
    01/01/2020 Authors: Douglas I; Alapat P; Corl K; Exline M; Forni L; Holder A; Kaufman D; Khan A; Levy M; Martin G
  • Increasing Cardiovascular Data Sampling Frequency and Referencing It to Baseline Improve Hemorrhage Detection.
    Crit Care Explor Volume: 1 Page(s): e0058
    10/01/2019 Authors: Wertz A; Holder AL; Guillame-Bert M; Clermont G; Dubrawski A; Pinsky MR
  • THE RELATIONSHIP BETWEEN QSOFA SCORE, PRELOAD FUNCTIONAL STATUS, AND PATIENT OUTCOME
    Volume: 47
    01/01/2019 Authors: Douglas I; Alapat P; Corl K; Exline M; Forni L; Holder A; Kaufman D; Khan A; Levy M; Martin G
  • Decreased Change in Stroke Volume in Patients with Sepsis and Septic Shock
    Volume: 199
    01/01/2019 Authors: Douglas IS; Alapat PM; Corl K; Exline MC; Forni L; Holder A; Kaufman DA; Khan A; Levy MM; Martin GS
  • Physiology of Fluid Responsiveness in Sepsis
    Volume: 199
    01/01/2019 Authors: Douglas IS; Alapat PM; Corl K; Exline MC; Forni L; Holder A; Kaufman DA; Khan A; Levy MM; Martin GS
  • A FHIR-Enabled Streaming Sepsis Prediction System for ICUs.
    Volume: 2018 Page(s): 4093 - 4096
    07/01/2018 Authors: Henry JR; Lynch D; Mals J; Shashikumar SP; Holder A; Sharma A; Nemati S
  • Doubly-Robust Estimation of Effect of Imaging Resource Utilization on Discharge Decisions in Emergency Departments.
    Annu Int Conf IEEE Eng Med Biol Soc Volume: 2018 Page(s): 3256 - 3259
    07/01/2018 Authors: Tabaie A; Chokshi FH; Holder AL; Nemati SN
  • MODIFYING THE SHOCK INDEX DOES NOT IMPROVE SEPTIC SHOCK PREDICTION IN PATIENTS WITH INFECTION
    Volume: 49 Page(s): 138 - 138
    06/01/2018 Authors: Tabaie A; Nemati S; Holder AL
  • An Interpretable Machine Learning Model for Accurate Prediction of Sepsis in the ICU.
    Crit Care Med Volume: 46 Page(s): 547 - 553
    04/01/2018 Authors: Nemati S; Holder A; Razmi F; Stanley MD; Clifford GD; Buchman TG
  • Evaluation of Heart Function in Non-Fluid Responsive Patients with Septic Shock
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 197
    01/01/2018 Authors: Douglas IS; Alapat PM; Corl K; Forni L; Holder AL; Kaufman DA; Levy MM; Martin GS; Sahatjian J; Seeley EJ
  • Serial Daily Organ Failure Assessment Beyond ICU Day 5 Does Not Independently Add Precision to ICU Risk-of-Death Prediction.
    Crit Care Med Volume: 45 Page(s): 2014 - 2022
    12/01/2017 Authors: Holder AL; Overton E; Lyu P; Kempker JA; Nemati S; Razmi F; Martin GS; Buchman TG; Murphy DJ
  • Measuring Fellows' Willingness to Challenge Authority Using an Objective Structured Clinical Examination
    Volume: 152 Page(s): 563A - 563A
    10/01/2017 Authors: Schulman D; Holder A; Fugate K; Timmer M; Wright M; Esper A
  • Early sepsis detection in critical care patients using multiscale blood pressure and heart rate dynamics.
    J Electrocardiol Volume: 50 Page(s): 739 - 743
    01/01/2017 Authors: Shashikumar SP; Stanley MD; Sadiq I; Li Q; Holder A; Clifford GD; Nemati S
  • Predictors of early progression to severe sepsis or shock among emergency department patients with nonsevere sepsis.
    Int J Emerg Med Volume: 9 Page(s): 10
    12/01/2016 Authors: Holder AL; Gupta N; Lulaj E; Furgiuele M; Hidalgo I; Jones MP; Jolly T; Gennis P; Birnbaum A
  • Hotspotting sepsis: applying analytic tools from other disciplines to eliminate disparities.
    Ann Transl Med Volume: 4 Page(s): 295
    08/01/2016 Authors: Holder AL; Wallace DJ; Martin GS
  • Inhaled, nebulized sodium nitrite protects in murine and porcine experimental models of hemorrhagic shock and resuscitation by limiting mitochondrial injury.
    Nitric Oxide Volume: 51 Page(s): 7 - 18
    12/01/2015 Authors: Kautza B; Gomez H; Escobar D; Corey C; Ataya B; Luciano J; Botero AM; Gordon L; Brumfield J; Martinez S
  • Effects of inhalation of low-dose nitrite or carbon monoxide on post-reperfusion mitochondrial function and tissue injury in hemorrhagic shock swine.
    Crit Care Volume: 19 Page(s): 184
    04/22/2015 Authors: Haugaa H; Gmez H; Maberry DR; Holder A; Ogundele O; Quintero AMB; Escobar D; Tnnessen TI; Airgood H; Dezfulian C
  • Inhaled Carbon Monoxide Protects against the Development of Shock and Mitochondrial Injury following Hemorrhage and Resuscitation.
    PLoS One Volume: 10 Page(s): e0135032
    01/01/2015 Authors: Gomez H; Kautza B; Escobar D; Nassour I; Luciano J; Botero AM; Gordon L; Martinez S; Holder A; Ogundele O
  • Using what you get: dynamic physiologic signatures of critical illness.
    Crit Care Clin Volume: 31 Page(s): 133 - 164
    01/01/2015 Authors: Holder AL; Clermont G
  • Applied physiology at the bedside to drive resuscitation algorithms.
    J Cardiothorac Vasc Anesth Volume: 28 Page(s): 1642 - 1659
    12/01/2014 Authors: Holder AL; Pinsky MR
  • UTILITY OF EMPIRICAL MODELS OF HEMORRHAGE IN DETECTING AND QUANTIFYING BLEEDING
    Volume: 40 Page(s): S287 - S287
    09/01/2014 Authors: Guillame-Bert M; Dubrawski A; Chen L; Holder A; Pinsky MR; Clermont G
  • A dream deferred: the rise and fall of recombinant activated protein C.
    Crit Care Volume: 17 Page(s): 309
    03/12/2013 Authors: Holder AL; Huang DT
  • Vaginal tenofovir (TFV) gel is effective against transmission of TFV-resistant virus in macaques
    Volume: 16 Page(s): A39 - A39
    01/01/2011 Authors: Dobard C; Sharma S; Cong M; Lipscomb J; West R; Holder A; Pau C-P; Smith J; Novembre F; Garcia-Lerma J
  • Semi automated adjudication of vital sign alerts in step-down units.

    Authors: Fiterau M; Dubrawski A; Wang D; Chen L; Guillame-Bert M; Hravnak M; Clermont G; Bose E; Holder A; Murat Kaynar A
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