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Profile

Kathy Griendling PhD

  • Department of Medicine
    Professor
  • (404) 727-3364
  • kgriend@emory.edu
  • Griendling Basic Science Cardiology Lab
  • Lab Address
    HSRBII, 2nd floor
  • Emory University
    Medicine/Cardiology
    254N HSRBII, 1750 Haygood Drive
Head shot of Kathy Griendling

Overview

Dr. Kathy Griendling received her PhD in Cardiovascular Physiology from Johns Hopkins University. She is currently a Professor of Medicine in the Cardiology Division of Emory University and Executive Associate Dean for Faculty Affairs and Professional Development in the School of Medicine. Her research has been focused on the role of NADPH oxidases (Nox) in vascular biology and disease. She has a particular interest in how reactive oxygen species (ROS) derived from these enzymes regulate the signaling pathways leading to smooth muscle proliferation, migration and differentiation. Using transgenic and knockout mouse models, her laboratory has demonstrated a role for the NADPH oxidases in hypertension, collateral formation, vessel contraction and restenosis. Ongoing research is focused on Poldip2, a p22phox binding protein that regulates Nox4 activity and plays major roles in cell cycle progression, matrix regulation, and endothelial barrier function. Dr. Griendling has trained 46 post-doctoral fellows and PhD students, many of whom have successful academic careers. She is a member of the graduate faculty in Molecular and Systems Pharmacology.

Academic Appointment

  • R. Wayne Alexander MD Professor of Medicine, Emory University School of Medicine
  • Professor of Medicine, Emory University School of Medicine

Education

Degrees

  • PhD from Johns Hopkins University School of Medicine
  • BS, Biology from Pennsylvania State University
  • BS, Mathematics from Pennsylvania State University

Research

Focus

  • Vascular Biology

    Dr. Griendlings laboratory was one of the first to identify the role of the NADPH oxidases (Nox enzymes) in vascular physiology and pathophysiology. She and her colleagues identified the functions of Nox1 and Nox4 and explored their individual roles in vascular physiology and pathology. Their work has provided insight into NADPH oxidase activators, their subunit composition, the specific signaling pathways that they modify, their roles in migration, differentiation, growth and cytoskeletal reorganization, and their roles in hypertension and diabetic vascular disease. Most recently, her laboratory discovered, cloned and characterized the first known regulator of Nox4, Poldip2, and current work is focused on the physiology and pathophysiology of this novel and complex protein.

Publications

  • Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border.
    Cell Commun Signal Volume: 23 Page(s): 9
    01/07/2025 Authors: Wang K; Qu H; Hu R; Lassgue B; Eaton DC; Song C; Mu J; Griendling KK; Hernandes MS
  • RNA Sequencing Atherosclerosis Data Sets: Expanding Potential Therapeutic Targets.
    Circ Res Volume: 134 Page(s): 1424 - 1426
    05/24/2024 Authors: Hernandes MS; Griendling KK
  • Novel role of vascular chemerin in blood vessel tone.
    Am J Physiol Heart Circ Physiol Volume: 325 Page(s): H321 - H322
    08/01/2023 Authors: Hu R; Bulger DA; Griendling KK
  • Novel Mechanism by Which Extracellular Cyclic GMP Induces Natriuresis.
    Circ Res Volume: 132 Page(s): 1141 - 1143
    04/28/2023 Authors: Bulger DA; Griendling KK
  • Doris Duke Charitable Foundation Fund to Retain Clinical Scientists: innovating support for early-career family caregivers.
    J Clin Invest Volume: 132
    12/01/2022 Authors: Jagsi R; Beeland TD; Sia K; Szczygiel LA; Allen MR; Arora VM; Bair-Merritt M; Bauman MD; Bogner HR; Daumit G
  • Role of NADPH Oxidases in Blood-Brain Barrier Disruption and Ischemic Stroke.
    Antioxidants (Basel) Volume: 11
    09/30/2022 Authors: Hernandes MS; Xu Q; Griendling KK
  • Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation.
    Cardiovasc Res Volume: 118 Page(s): 2506 - 2518
    08/24/2022 Authors: Dolmatova EV; Forrester SJ; Wang K; Ou Z; Williams HC; Joseph G; Kumar S; Valdivia A; Kowalczyk AP; Qu H
  • Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome.
    J Am Heart Assoc Volume: 11 Page(s): e025181
    05/17/2022 Authors: Ou Z; Dolmatova E; Mandavilli R; Qu H; Gafford G; White T; Valdivia A; Lassgue B; Hernandes MS; Griendling KK
  • NADPH Oxidase 1 Mediates Acute Blood Pressure Response to Angiotensin II by Contributing to Calcium Influx in Vascular Smooth Muscle Cells.
    Arterioscler Thromb Vasc Biol Volume: 42 Page(s): e117 - e130
    05/01/2022 Authors: Park J-M; Do VQ; Seo Y-S; Kim HJ; Nam JH; Yin MZ; Kim HJ; Kim SJ; Griendling KK; Lee M-Y
  • Oxidative Stress and Hypertension.
    Circ Res Volume: 128 Page(s): 993 - 1020
    04/02/2021 Authors: Griendling KK; Camargo LL; Rios FJ; Alves-Lopes R; Montezano AC; Touyz RM
  • Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction.
    Sci Rep Volume: 11 Page(s): 5533
    03/10/2021 Authors: Eidson LN; Gao Q; Qu H; Kikuchi DS; Campos ACP; Faidley EA; Sun Y-Y; Kuan C-Y; Pagano RL; Lassgue B
  • 1- and 2-integrins: central players in regulating vascular permeability and leukocyte recruitment during acute inflammation.
    Am J Physiol Heart Circ Physiol Volume: 320 Page(s): H734 - H739
    02/01/2021 Authors: Ou Z; Dolmatova E; Lassgue B; Griendling KK
  • Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting.
    PLoS One Volume: 16 Page(s): e0247261
    01/01/2021 Authors: Lassgue B; Kumar S; Mandavilli R; Wang K; Tsai M; Kang D-W; Demos C; Hernandes MS; San Martn A; Taylor WR
  • The effects of sepsis on endothelium and clinical implications.
    Cardiovasc Res Volume: 117 Page(s): 60 - 73
    01/01/2021 Authors: Dolmatova EV; Wang K; Mandavilli R; Griendling KK
  • Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices.
    Hypertension Volume: 76 Page(s): 1350 - 1367
    11/01/2020 Authors: Sparks MA; South AM; Badley AD; Baker-Smith CM; Batlle D; Bozkurt B; Cattaneo R; Crowley SD; Dell'Italia LJ; Ford AL
  • VE-cadherin endocytosis controls vascular integrity and patterning during development
    Volume: 140 Page(s): S21 - S21
    07/01/2020 Authors: Grimsley-Myers CM; Isaacson R; Cadwell C; Campos J; Hernandes M; Myers K; Seo T; Giang W; Griendling K; Kowalczyk A
  • VE-cadherin endocytosis controls vascular integrity and patterning during development.
    J Cell Biol Volume: 219
    05/04/2020 Authors: Grimsley-Myers CM; Isaacson RH; Cadwell CM; Campos J; Hernandes MS; Myers KR; Seo T; Giang W; Griendling KK; Kowalczyk AP
  • An acceleration in hypertension-related mortality for middle-aged and older Americans, 1999-2016: An observational study.
    PLoS One Volume: 15 Page(s): e0225207
    01/01/2020 Authors: Forrester SJ; Dolmatova EV; Griendling KK
  • Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy.
    J Neuroinflammation Volume: 16 Page(s): 241
    11/28/2019 Authors: Kikuchi DS; Campos ACP; Qu H; Forrester SJ; Pagano RL; Lassgue B; Sadikot RT; Griendling KK; Hernandes MS
  • The interdependent effects of cholesterol and substrate stiffness on vascular smooth muscle cell biomechanics.
    Cardiovasc Res Volume: 115 Page(s): 1262 - 1263
    07/01/2019 Authors: Forrester SJ; Griendling KK
  • Polymerase--interacting protein 2 activates the RhoGEF epithelial cell transforming sequence 2 in vascular smooth muscle cells.
    Am J Physiol Cell Physiol Volume: 316 Page(s): C621 - C631
    05/01/2019 Authors: Huff LP; Kikuchi DS; Faidley E; Forrester SJ; Tsai MZ; Lassgue B; Griendling KK
  • OPNa and OPNc Contribute to PDGF-Induced Vascular Smooth Muscle Cell Migration and Proliferation
    Volume: 39
    05/01/2019 Authors: Lee GS; Lok ZS; Salazar HF; Tsai MZ; Lassegue B; Harirforoosh S; Griendling KK; Lyle AN
  • Poldip2 knockdown inhibits vascular smooth muscle proliferation and neointima formation by regulating the expression of PCNA and p21.
    Lab Invest Volume: 99 Page(s): 387 - 398
    03/01/2019 Authors: Datla SR; L Hilenski L; Seidel-Rogol B; Dikalova AE; Harousseau M; Punkova L; Joseph G; Taylor WR; Lassgue B; Griendling KK
  • Platelet microRNAs and vascular injury.
    J Clin Invest Volume: 129 Page(s): 962 - 964
    03/01/2019 Authors: Dolmatova EV; Griendling KK
  • Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome.
    Clin Sci (Lond) Volume: 133 Page(s): 321 - 334
    01/31/2019 Authors: Forrester SJ; Xu Q; Kikuchi DS; Okwan-Duodu D; Campos AC; Faidley EA; Zhang G; Lassgue B; Sadikot RT; Griendling KK
  • Redox Modification of the Cytoskeleton During Cell Adhesion and Migration
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 128 Page(s): S5 - S5
    11/20/2018 Authors: Griendling K
  • The Role of Polymerase Delta-Interacting Protein 2 in Pulmonary Vascular Inflammation
    Volume: 138
    11/06/2018 Authors: Forrester SJ; Xu Q; Kikuchi DS; Okwan-Duodu D; Lassegue B; Sadikot R; Hernandes MS; Griendling KK
  • Poldip2 Regulates Cyclooxygenase-2 Expression and Mediates Lipopolysaccharide-Induced Blood-Brain Barrier Disruption
    Volume: 138
    11/06/2018 Authors: Kikuchi DS; Campos AC; Forrester SJ; Lassegue B; Sadikot RT; Griendling KK; Hernandes MS
  • High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass.
    Hypertension Volume: 72 Page(s): 1208 - 1216
    11/01/2018 Authors: Li L; Lai EY; Luo Z; Solis G; Mendonca M; Griendling KK; Wellstein A; Welch WJ; Wilcox CS
  • NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase -Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.
    Arterioscler Thromb Vasc Biol Volume: 38 Page(s): 2423 - 2434
    10/01/2018 Authors: Vukelic S; Xu Q; Seidel-Rogol B; Faidley EA; Dikalova AE; Hilenski LL; Jorde U; Poole LB; Lassgue B; Zhang G
  • High Salt Enhances ROS and Ang II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass
    Volume: 72
    09/01/2018 Authors: Li L; Lai E; Luo Z; Solis G; Mendonca M; Griendling K; Wellstein A; Welch W; Wilcox CS
  • Reply to Bailey et al.: New perspectives on the novel role of the Poldip2/ACSM1 axis in a functional mammalian lipoylation salvage pathway.
    Proc Natl Acad Sci U S A Volume: 115 Page(s): E7460 - E7461
    08/07/2018 Authors: Paredes F; Lassgue B; Williams HC; Faidley EA; Benavides GA; Yeligar SM; Griendling KK; Darley-Usmar V; San Martin A
  • Reactive Oxygen Species in Metabolic and Inflammatory Signaling.
    Circ Res Volume: 122 Page(s): 877 - 902
    03/16/2018 Authors: Forrester SJ; Kikuchi DS; Hernandes MS; Xu Q; Griendling KK
  • Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4.
    Bioorg Med Chem Volume: 26 Page(s): 989 - 998
    03/01/2018 Authors: Xu Q; Kulkarni AA; Sajith AM; Hussein D; Brown D; Gner OF; Reddy MD; Watkins EB; Lassgue B; Griendling KK
  • Poldip2 is an oxygen-sensitive protein that controls PDH and KGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.
    Proc Natl Acad Sci U S A Volume: 115 Page(s): 1789 - 1794
    02/20/2018 Authors: Paredes F; Sheldon K; Lassgue B; Williams HC; Faidley EA; Benavides GA; Torres G; Sanhueza-Olivares F; Yeligar SM; Griendling KK
  • Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain.
    J Neuroinflammation Volume: 15 Page(s): 45
    02/17/2018 Authors: Hernandes MS; Lassgue B; Hilenski LL; Adams J; Gao N; Kuan C-Y; Sun Y-Y; Cheng L; Kikuchi DS; Yepes M
  • Mitochondrial Respiration and Atherosclerosis: R-E-S-P-I-R-E. Find Out What it Means to M (and VSMC).
    Arterioscler Thromb Vasc Biol Volume: 37 Page(s): 2229 - 2230
    12/01/2017 Authors: Forrester SJ; Griendling KK
  • The Role of Poldip2/NOX4 in Redox Regulation of Actin During Integrin-Mediated Cell Adhesion
    CIRCULATION Volume: 136
    11/14/2017 Authors: Xu Q; Vukelic S; Faidley E; Lassegue B; Griendling K
  • Poldip2 Activates the Rho Guanine Nucleotide Exchange Factor Ect2 To Regulate Vascular Smooth Muscle Cell Proliferation
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 112 Page(s): 115 - 116
    11/01/2017 Authors: Kikuchi D; Huff L; Lassegue B; Griendling K
  • Superoxide and hydrogen peroxide counterregulate myogenic contractions in renal afferent arterioles from a mouse model of chronic kidney disease.
    Kidney Int Volume: 92 Page(s): 625 - 633
    09/01/2017 Authors: Li L; Lai EY; Luo Z; Solis G; Griendling KK; Taylor WR; Jose PA; Wellstein A; Welch WJ; Wilcox CS
  • Redox regulation of the actin cytoskeleton and its role in the vascular system.
    Free Radic Biol Med Volume: 109 Page(s): 84 - 107
    08/01/2017 Authors: Xu Q; Huff LP; Fujii M; Griendling KK
  • Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association.
    Circ Res Volume: 121 Page(s): e2 - e8
    07/21/2017 Authors: Hill JA; Ardehali R; Clarke KT; Del Zoppo GJ; Eckhardt LL; Griendling KK; Libby P; Roden DM; Sadek HA; Seidman CE
  • Zinc regulates Nox1 expression through a NF-B and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells.
    Free Radic Biol Med Volume: 108 Page(s): 225 - 235
    07/01/2017 Authors: Salazar G; Huang J; Feresin RG; Zhao Y; Griendling KK
  • FGF Suppresses Poldip2 Expression in Osteoblasts.
    J Cell Biochem Volume: 118 Page(s): 1670 - 1677
    07/01/2017 Authors: Katsumura S; Izu Y; Yamada T; Griendling K; Harada K; Noda M; Ezura Y
  • Polymerase -interacting Protein 2: A Multifunctional Protein.
    J Cardiovasc Pharmacol Volume: 69 Page(s): 335 - 342
    06/01/2017 Authors: Hernandes MS; Lassgue B; Griendling KK
  • Tempol prevents the enhancement of angiotensin II contractions of afferent arterioles from mouse with reduced renal mass
    FASEB JOURNAL Volume: 31
    04/01/2017 Authors: Li L; Lai EY; Luo Z; Griendling KK; Taylor WRK; Wellsten A; Welch WJ; Wilcox CS
  • Cyclic Strain and Hypertension Increase Osteopontin Expression in the Aorta.
    Cell Mol Bioeng Volume: 10 Page(s): 144 - 152
    04/01/2017 Authors: Caesar C; Lyle AN; Joseph G; Weiss D; Alameddine FMF; Lassgue B; Griendling KK; Taylor WR
  • NADPH Oxidases and Measurement of Reactive Oxygen Species.
    Volume: 1527 Page(s): 219 - 232
    01/01/2017 Authors: Amanso A; Lyle AN; Griendling KK
  • Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.
    Circ Res Volume: 119 Page(s): e39 - e75
    08/19/2016 Authors: Griendling KK; Touyz RM; Zweier JL; Dikalov S; Chilian W; Chen Y-R; Harrison DG; Bhatnagar A; American Heart Association Council on Basic Cardiovascular Sciences
  • NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis.
    Free Radic Biol Med Volume: 97 Page(s): 556 - 567
    08/01/2016 Authors: Di Marco E; Gray SP; Kennedy K; Szyndralewiez C; Lyle AN; Lassgue B; Griendling KK; Cooper ME; Schmidt HHHW; Jandeleit-Dahm KAM
  • Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells.
    J Mol Cell Cardiol Volume: 92 Page(s): 21 - 29
    03/01/2016 Authors: Fujii M; Amanso A; Abraho TB; Lassgue B; Griendling KK
  • Polymerase [delta]-Interacting Protein 2 Regulates Astrocyte Activation in Ischemic Stroke
    STROKE Volume: 47
    02/01/2016 Authors: Hernandes MS; Lassegue B; Yepes M; Griendling K
  • Redox-Sensitive Regulation of Myocardin-Related Transcription Factor (MRTF-A) Phosphorylation via Palladin in Vascular Smooth Muscle Cell Differentiation Marker Gene Expression.
    PLoS One Volume: 11 Page(s): e0153199
    01/01/2016 Authors: Lee M; San Martn A; Valdivia A; Martin-Garrido A; Griendling KK
  • Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout.
    Antioxid Redox Signal Volume: 23 Page(s): 1246 - 1247
    11/20/2015 Authors: Pagano PJ; Griendling KK; Miller FJ; Laurindo FRM; Touyz RM
  • Premature vascular aging in aldosterone-associated hypertension: role of Nox1
    EUROPEAN HEART JOURNAL Volume: 36 Page(s): 438 - 438
    08/01/2015 Authors: Harvey A; Montezano AC; Graham D; He Y; Ceravolo G; Yabe-Nishimura C; Griendling K; Touyz RM
  • Hic-5 Mediates TGF-Induced Adhesion in Vascular Smooth Muscle Cells by a Nox4-Dependent Mechanism.
    Arterioscler Thromb Vasc Biol Volume: 35 Page(s): 1198 - 1206
    05/01/2015 Authors: Fernandez I; Martin-Garrido A; Zhou DW; Clempus RE; Seidel-Rogol B; Valdivia A; Lassgue B; Garca AJ; Griendling KK; San Martin A
  • Nuclear factor (erythroid-derived 2)-like 2, the brake in oxidative stress that nicotinamide adenine dinucleotide phosphate-oxidase-4 needs to protect the heart.
    Hypertension Volume: 65 Page(s): 499 - 501
    03/01/2015 Authors: Abrahao TB; Griendling KK
  • Regulation of signal transduction by reactive oxygen species in the cardiovascular system.
    Circ Res Volume: 116 Page(s): 531 - 549
    01/30/2015 Authors: Brown DI; Griendling KK
  • Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization.
    Am J Physiol Heart Circ Physiol Volume: 307 Page(s): H945 - H957
    10/01/2014 Authors: Datla SR; McGrail DJ; Vukelic S; Huff LP; Lyle AN; Pounkova L; Lee M; Seidel-Rogol B; Khalil MK; Hilenski LL
  • RhoA/Rho kinase mediates TGF-1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species.
    Am J Physiol Renal Physiol Volume: 307 Page(s): F159 - F171
    07/15/2014 Authors: Manickam N; Patel M; Griendling KK; Gorin Y; Barnes JL
  • P708Homocysteine induces apoptosis of arterial smooth muscle cells via NOX4-produced reactive oxygen.
    Cardiovasc Res Volume: 103 Suppl 1 Page(s): S129
    07/15/2014 Authors: Ter Horst EN; Hahn N; Sipkens J; Van Hinsbergh V; Musters R; Smulders Y; Eringa E; Griendling K; Niessen H; Krijnen P
  • Polymerase -interacting protein 2 promotes postischemic neovascularization of the mouse hindlimb.
    Arterioscler Thromb Vasc Biol Volume: 34 Page(s): 1548 - 1555
    07/01/2014 Authors: Amanso AM; Lassgue B; Joseph G; Landzuri N; Long JS; Weiss D; Taylor WR; Griendling KK
  • Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice.
    Arterioscler Thromb Vasc Biol Volume: 34 Page(s): 1412 - 1421
    07/01/2014 Authors: Kim CW; Kumar S; Son DJ; Jang I-H; Griendling KK; Jo H
  • NADPH oxidases: progress and opportunities.
    Antioxid Redox Signal Volume: 20 Page(s): 2692 - 2694
    06/10/2014 Authors: San Martin A; Griendling KK
  • Relaxin Attenuates Angiotensin II-Induced Proinflammatory Signaling in Vascular Smooth Muscle Cells
    Volume: 34
    05/01/2014 Authors: Vukelic S; Lassegue B; Griendling K
  • Angiotensin II, from vasoconstrictor to growth factor: a paradigm shift.
    Circ Res Volume: 114 Page(s): 754 - 757
    02/28/2014 Authors: Vukelic S; Griendling KK
  • Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension.
    Antioxid Redox Signal Volume: 20 Page(s): 281 - 294
    01/10/2014 Authors: Dikalov SI; Nazarewicz RR; Bikineyeva A; Hilenski L; Lassgue B; Griendling KK; Harrison DG; Dikalova AE
  • Hydrogen peroxide regulates osteopontin expression through activation of transcriptional and translational pathways.
    J Biol Chem Volume: 289 Page(s): 275 - 285
    01/03/2014 Authors: Lyle AN; Remus EW; Fan AE; Lassgue B; Walter GA; Kiyosue A; Griendling KK; Taylor WR
  • Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts.
    PLoS One Volume: 9 Page(s): e96657
    01/01/2014 Authors: Brown DI; Lassgue B; Lee M; Zafari R; Long JS; Saavedra HI; Griendling KK
  • Multiple Roles of NADPH Oxidases in the Vasculature
    JOURNAL OF PHARMACOLOGICAL SCIENCES Volume: 124 Page(s): 8P - 8P
    01/01/2014 Authors: Griendling K
  • Role of beta PIX in PDGF-Induced Lamellipodia Dynamics in VSMC
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 65 Page(s): S157 - S157
    11/01/2013 Authors: Duran C; Williams HC; Lassegue B; Griendling KK; San Martin A
  • TGF-beta Mediates Focal Adhesion Maturation by a Smad/Nox4-Dependent Mechanism that Involves Regulation of Hsp27 and Hic5
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 65 Page(s): S157 - S157
    11/01/2013 Authors: Fernandez I; Martin-Garrido A; Clempus RE; Seidel-Rogol B; Amanso A; Lassegue B; Griendling KK; San Martin A
  • MicroRNA-34a Accelerates Aging in Vascular Smooth Muscle Cells (SMCs) Isolated from Transgenic Mice Overexpressing Nox1 in SMCs
    HYPERTENSION Volume: 62
    09/01/2013 Authors: Luo Z; Fan L; Wellstein A; Griendling KK; Welch WJ; Wilcox CS
  • The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice.
    Am J Physiol Heart Circ Physiol Volume: 305 Page(s): H747 - H755
    09/01/2013 Authors: Koga M; Engberding N; Dikalova AE; Chang KH; Seidel-Rogol B; Long JS; Lassgue B; Jo H; Griendling KK
  • Polymerase delta interacting protein 2 sustains vascular structure and function.
    Arterioscler Thromb Vasc Biol Volume: 33 Page(s): 2154 - 2161
    09/01/2013 Authors: Sutliff RL; Hilenski LL; Amanso AM; Parastatidis I; Dikalova AE; Hansen L; Datla SR; Long JS; El-Ali AM; Joseph G
  • Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells.
    Arterioscler Thromb Vasc Biol Volume: 33 Page(s): 1350 - 1359
    06/01/2013 Authors: Kim CW; Song H; Kumar S; Nam D; Kwon HS; Chang KH; Son DJ; Kang D-W; Brodie SA; Weiss D
  • Transforming growth factor inhibits platelet derived growth factor-induced vascular smooth muscle cell proliferation via Akt-independent, Smad-mediated cyclin D1 downregulation.
    PLoS One Volume: 8 Page(s): e79657
    01/01/2013 Authors: Martin-Garrido A; Williams HC; Lee M; Seidel-Rogol B; Ci X; Dong J-T; Lassgue B; Martn AS; Griendling KK
  • Poldip 2 Regulates Adhesion and Spreading of Vascular Smooth Muscle Cells Through Its Interaction With Kindlin-2 and Talin
    CIRCULATION Volume: 126
    11/20/2012 Authors: Khalil MK; Lassegue B; McGrail D; Datla SR; San Martin A; Dawson M; Griendling K
  • NADPH Oxidases as Mediators of Vascular Physiology
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 53 Page(s): S3 - S3
    09/01/2012 Authors: Griendling K
  • Effects of the antioxidant drug tempol on renal oxygenation in mice with reduced renal mass.
    Am J Physiol Renal Physiol Volume: 303 Page(s): F64 - F74
    07/01/2012 Authors: Lai EY; Luo Z; Onozato ML; Rudolph EH; Solis G; Jose PA; Wellstein A; Aslam S; Quinn MT; Griendling K
  • Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells.
    Circ Res Volume: 111 Page(s): 56 - 65
    06/22/2012 Authors: Williams HC; San Martn A; Adamo CM; Seidel-Rogol B; Pounkova L; Datla SR; Lassgue B; Bear JE; Griendling K
  • Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system.
    Circ Res Volume: 110 Page(s): 1364 - 1390
    05/11/2012 Authors: Lassgue B; San Martn A; Griendling KK
  • Differential roles of NADPH oxidases in vascular physiology and pathophysiology.
    Front Biosci (Schol Ed) Volume: 4 Page(s): 1044 - 1064
    01/01/2012 Authors: Amanso AM; Griendling KK
  • Increased expression of Nox1 in neointimal smooth muscle cells promotes activation of matrix metalloproteinase-9.
    J Vasc Res Volume: 49 Page(s): 242 - 248
    01/01/2012 Authors: Xu S; Shriver AS; Jagadeesha DK; Chamseddine AH; Szcs K; Weintraub NL; Griendling KK; Bhalla RC; Miller FJ
  • Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK.
    Am J Physiol Cell Physiol Volume: 301 Page(s): C1415 - C1422
    12/01/2011 Authors: Hitomi H; Mehta PK; Taniyama Y; Lassgue B; Seidel-Rogol B; San Martin A; Griendling KK
  • Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor.
    Exp Cell Res Volume: 317 Page(s): 2420 - 2428
    10/15/2011 Authors: Liu G; Hitomi H; Hosomi N; Lei B; Nakano D; Deguchi K; Mori H; Masaki T; Ma H; Griendling KK
  • Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells.
    J Biol Chem Volume: 286 Page(s): 35430 - 35437
    10/14/2011 Authors: Maheswaranathan M; Gole HKA; Fernandez I; Lassgue B; Griendling KK; San Martn A
  • Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling.
    Free Radic Biol Med Volume: 51 Page(s): 1271 - 1288
    10/01/2011 Authors: Al Ghouleh I; Khoo NKH; Knaus UG; Griendling KK; Touyz RM; Thannickal VJ; Barchowsky A; Nauseef WM; Kelley EE; Bauer PM
  • Career development of physician scientists: a survey of leaders in academic medicine.
    Am J Med Volume: 124 Page(s): 779 - 787
    08/01/2011 Authors: Shea JA; Stern DT; Klotman PE; Clayton CP; O'Hara JL; Feldman MD; Griendling KK; Moss M; Straus SE; Jagsi R
  • Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.
    Nat Rev Drug Discov Volume: 10 Page(s): 453 - 471
    06/01/2011 Authors: Drummond GR; Selemidis S; Griendling KK; Sobey CG
  • Regulation of cytoplasmic NADPH oxidase by mitochondrial ATP-sensitive potassium channel and mitochondrial superoxide
    FASEB JOURNAL Volume: 25
    04/01/2011 Authors: Nazarewicz R; Dikalova A; Bikineyeva A; Mayorov V; Hilenski L; Lassegue B; Griendling K; Dikalov S
  • NADPH oxidase 4 mediates TGF--induced smooth muscle -actin via p38MAPK and serum response factor.
    Free Radic Biol Med Volume: 50 Page(s): 354 - 362
    01/15/2011 Authors: Martin-Garrido A; Brown DI; Lyle AN; Dikalova A; Seidel-Rogol B; Lassgue B; San Martn A; Griendling KK
  • Poldip2, a Nox4 Interacting Protein, Regulates Vascular Smooth Muscle Cell Migration via RhoA-Dependent Focal Adhesion Turnover
    CIRCULATION Volume: 122
    11/23/2010 Authors: Datla SR; Dikalova A; Lyle AN; Hilenski LL; Lassegue B; Griendling KK
  • Angiotensin II and NADPH oxidase increase ADMA in vascular smooth muscle cells.
    Hypertension Volume: 56 Page(s): 498 - 504
    09/01/2010 Authors: Luo Z; Teerlink T; Griendling K; Aslam S; Welch WJ; Wilcox CS
  • Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling.
    Am J Physiol Heart Circ Physiol Volume: 299 Page(s): H673 - H679
    09/01/2010 Authors: Dikalova AE; Gngora MC; Harrison DG; Lambeth JD; Dikalov S; Griendling KK
  • Reactive oxygen species, NADPH oxidases, and hypertension.
    Hypertension Volume: 56 Page(s): 325 - 330
    09/01/2010 Authors: Datla SR; Griendling KK
  • Nox1-mediated activation of Slingshot phosphatase in VSMC
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: San Martin A; Maheswaranathan M; Griendling KK
  • PDGF-induced Vascular Smooth Muscle Cell Migration is Regulated by Coronin 1b
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Williams HC; San Martin A; Griendling KK
  • NADPH oxidases: functions and pathologies in the vasculature.
    Arterioscler Thromb Vasc Biol Volume: 30 Page(s): 653 - 661
    04/01/2010 Authors: Lassgue B; Griendling KK
  • Redox control of vascular smooth muscle migration.
    Antioxid Redox Signal Volume: 12 Page(s): 625 - 640
    03/01/2010 Authors: San Martn A; Griendling KK
  • Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by upregulation of insulin-like growth factor-1 receptor
    ENDOCRINE JOURNAL Volume: 57 Page(s): S398 - S398
    03/01/2010 Authors: Hitomi H; Liu G; Hosomi N; Kiyomoto H; Lei B; Nakano D; Kohno M; Griendling K; Nishiyama A
  • Mitochondrial ATP-Sensitive Potassium Channel Regulates Cytoplasmic NADPH Oxidase Activity through Mitochondrial Superoxide
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 49 Page(s): S27 - S28
    01/01/2010 Authors: Nazarewicz R; Dikalova A; Bikineyeva A; Hilenski L; Lassegue B; Harrison D; Griendling K; Dikalov S
  • Role of Nox2-induced Reverse Electron Transfer in Production of Mitochondrial Reactive Oxygen Species, Endothelial Dysfunction and Hypertension
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 49 Page(s): S20 - S20
    01/01/2010 Authors: Dikalov S; Dikalova A; Nazarewicz R; Bikineyeva A; Mayorov V; Hilenski L; Lassegue B; Harrison D; Griendling K
  • Oxidative Stress and Cardiovascular Disease in Diabetes Mellitus
    Page(s): 263 - 279
    01/01/2010 Authors: Gupta D; Griendling KK; Taylor WR
  • Supplementation with Tetrahydrobiopterin Reverse Impaired Endothelium-Dependent Relaxation and eNOS Uncoupling Induced by Nox1 Overexpression in Vascular Smooth Muscle
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 49 Page(s): S180 - S180
    01/01/2010 Authors: Dikalova A; Gongora MC; Harrison D; Lambeth D; Dikalov S; Griendling K
  • Hydrogen peroxide down-regulates inositol 1,4,5-trisphosphate receptor content through proteasome activation.
    Free Radic Biol Med Volume: 47 Page(s): 1362 - 1370
    11/15/2009 Authors: Martn-Garrido A; Boyano-Adnez MC; Alique M; Calleros L; Serrano I; Griera M; Rodrguez-Puyol D; Griendling KK; Rodrguez-Puyol M
  • TGF beta Induction of Vascular Smooth Muscle Differentiation Markers is Mediated by Nox4 and p38 Mitogen-activated Protein Kinase
    CIRCULATION Volume: 120 Page(s): S1098 - S1098
    11/03/2009 Authors: Martin-Garrido A; Brown DI; Lyle AN; Dikalova A; Griendling KK
  • Nox proteins in signal transduction.
    Free Radic Biol Med Volume: 47 Page(s): 1239 - 1253
    11/01/2009 Authors: Brown DI; Griendling KK
  • Mechanical Stretch Augments Insulin-Induced Vascular Smooth Muscle Cell Proliferation by Insulin-like Growth Factor-1 Receptor
    HYPERTENSION Volume: 54 Page(s): E105 - E105
    10/01/2009 Authors: Hitomi H; Liu G; Hosomi N; Nakano D; Kiyomoto H; Kimura S; Kohno M; Griendling KK; Nishiyama A
  • NADPH oxidases: molecular understanding finally reaching the clinical level?
    Antioxid Redox Signal Volume: 11 Page(s): 2365 - 2370
    10/01/2009 Authors: Guzik TJ; Griendling KK
  • Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells.
    Circ Res Volume: 105 Page(s): 249 - 259
    07/31/2009 Authors: Lyle AN; Deshpande NN; Taniyama Y; Seidel-Rogol B; Pounkova L; Du P; Papaharalambus C; Lassgue B; Griendling KK
  • N0X4 Interactive Protein, N0XR1, Inhibits Vascular Smooth Muscle Cell Migration by Affecting the Focal Adhesion Turnover
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Volume: 29 Page(s): E115 - E116
    07/01/2009 Authors: Datla SR; Lyle AN; Griendling KK
  • NADPH oxidases and angiotensin II receptor signaling.
    Mol Cell Endocrinol Volume: 302 Page(s): 148 - 158
    04/29/2009 Authors: Garrido AM; Griendling KK
  • Regulation of the ADMA/PRMT/DDAH pathway in vascular smooth muscle cells by the p22phox component of NADPH oxidase
    FASEB JOURNAL Volume: 23
    04/01/2009 Authors: Luo Z; Welch W; Teerlink T; Griendling K; Wilcox C
  • Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation.
    Arterioscler Thromb Vasc Biol Volume: 29 Page(s): 480 - 487
    04/01/2009 Authors: Lee MY; San Martin A; Mehta PK; Dikalova AE; Garrido AM; Datla SR; Lyons E; Krause K-H; Banfi B; Lambeth JD
  • Insulin-like growth factor-1 receptor expression masks the antiinflammatory and glucose uptake capacity of insulin in vascular smooth muscle cells.
    Arterioscler Thromb Vasc Biol Volume: 29 Page(s): 408 - 415
    03/01/2009 Authors: Engberding N; San Martn A; Martin-Garrido A; Koga M; Pounkova L; Lyons E; Lassgue B; Griendling KK
  • Upregulation of Nox1 in Vascular Smooth Muscle Leads to Impaired Endothelium-Dependent Relaxation via eNOS Uncoupling
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 47 Page(s): S57 - S57
    01/01/2009 Authors: Dikalova A; Gongora MC; Harrison DG; Dikalov S; Lambeth D; Griendling K
  • ROLE OF Nox PROTEINS IN VASCULAR DISEASE
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 47 Page(s): S5 - S5
    01/01/2009 Authors: Griendling K
  • Pathogenesis of Hypertension: Vascular Mechanisms
    Page(s): 107 - 129
    01/01/2009 Authors: Alexander RW; Griendling KK
  • Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production.
    Free Radic Biol Med Volume: 45 Page(s): 1340 - 1351
    11/01/2008 Authors: Dikalov SI; Dikalova AE; Bikineyeva AT; Schmidt HHHW; Harrison DG; Griendling KK
  • Overexpression of P22phox Subunit of Nadph Oxidase in Mice Accelerates Cardiac Fibrosis and Angiogenesis in Response to Angiotensin Ii
    CIRCULATION Volume: 118 Page(s): S314 - S314
    10/28/2008 Authors: Llanos A; Cheng L; Cucoranu I; Qin Q; Griendling KK; Harrison DG; Sorescu D
  • Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression.
    J Biol Chem Volume: 283 Page(s): 24061 - 24076
    08/29/2008 Authors: Block K; Eid A; Griendling KK; Lee D-Y; Wittrant Y; Gorin Y
  • Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells.
    Free Radic Biol Med Volume: 45 Page(s): 329 - 335
    08/01/2008 Authors: Jay DB; Papaharalambus CA; Seidel-Rogol B; Dikalova AE; Lassgue B; Griendling KK
  • Redox signaling, vascular function, and hypertension.
    Antioxid Redox Signal Volume: 10 Page(s): 1045 - 1059
    06/01/2008 Authors: Lee MY; Griendling KK
  • Novel Nox1-mediated mechanism of SSH1L activation in VSMC: Role in cell migration
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Volume: 28 Page(s): E109 - E109
    06/01/2008 Authors: Martin AS; Lee MY; Griendling KK
  • NoxR1, a novel regulator of Nox4 in vascular smooth muscle cells
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Volume: 28 Page(s): E34 - E34
    06/01/2008 Authors: Lyle AN; Seidel-Rogol B; Lassegue B; Griendling KK
  • Downregulation of insulin-like growth factor-I receptors in vascular smooth muscle cells promotes anti-inflammatory effects of insulin
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Volume: 28 Page(s): E116 - E116
    06/01/2008 Authors: Engberding N; Griendling KK
  • Insulin-like growth factor-1 receptor expression regulates insulin sensitivity of vascular smooth muscle cells
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Volume: 51 Page(s): A341 - A341
    03/11/2008 Authors: Engberding N; Griendling KK
  • Dual regulation of cofilin activity by LIM kinase and Slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells.
    Circ Res Volume: 102 Page(s): 432 - 438
    02/29/2008 Authors: San Martn A; Lee MY; Williams HC; Mizuno K; Lassgue B; Griendling KK
  • Differential effects of AT1 receptor and Ca2+ channel blockade on atherosclerosis, inflammatory gene expression, and production of reactive oxygen species.
    Atherosclerosis Volume: 195 Page(s): 39 - 47
    11/01/2007 Authors: Doran DE; Weiss D; Zhang Y; Griendling KK; Taylor WR
  • NADPH oxidase inhibitors: new antihypertensive agents?
    J Cardiovasc Pharmacol Volume: 50 Page(s): 9 - 16
    07/01/2007 Authors: Williams HC; Griendling KK
  • Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products.
    Free Radic Biol Med Volume: 42 Page(s): 1671 - 1679
    06/01/2007 Authors: San Martin A; Foncea R; Laurindo FR; Ebensperger R; Griendling KK; Leighton F
  • Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes.
    Am J Physiol Heart Circ Physiol Volume: 292 Page(s): H2073 - H2082
    05/01/2007 Authors: San Martn A; Du P; Dikalova A; Lassgue B; Aleman M; Gngora MC; Brown K; Joseph G; Harrison DG; Taylor WR
  • Vitamin E reduces glomerulosclerosis, restores renal neuronal NOS, and suppresses oxidative stress in the 5/6 nephrectomized rat.
    Am J Physiol Renal Physiol Volume: 292 Page(s): F1404 - F1410
    05/01/2007 Authors: Tain Y-L; Freshour G; Dikalova A; Griendling K; Baylis C
  • Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II.
    Arterioscler Thromb Vasc Biol Volume: 27 Page(s): 762 - 768
    04/01/2007 Authors: Widder JD; Guzik TJ; Mueller CFH; Clempus RE; Schmidt HHHW; Dikalov SI; Griendling KK; Jones DP; Harrison DG
  • Measurement of reactive oxygen species in cardiovascular studies.
    Hypertension Volume: 49 Page(s): 717 - 727
    04/01/2007 Authors: Dikalov S; Griendling KK; Harrison DG
  • Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
    J Clin Invest Volume: 117 Page(s): 719 - 729
    03/01/2007 Authors: Govindarajan B; Sligh JE; Vincent BJ; Li M; Canter JA; Nickoloff BJ; Rodenburg RJ; Smeitink JA; Oberley L; Zhang Y
  • Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury.
    Trends Cardiovasc Med Volume: 17 Page(s): 48 - 54
    02/01/2007 Authors: Papaharalambus CA; Griendling KK
  • Distinct roles of Nox1 and Nox4 in basal and angiotensin II-Stimulated superoxide and hydrogen peroxide production
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 43 Page(s): S36 - S36
    01/01/2007 Authors: Dikalov SI; Dikalova AE; Bikineyeva AT; Harrison DG; Griendling KK
  • Mycophenolic acid is a new Nox2 inhibitor.
    Hypertension Volume: 49 Page(s): 25 - 26
    01/01/2007 Authors: Lassgue B; Griendling KK
  • Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity.
    Methods Mol Med Volume: 139 Page(s): 293 - 311
    01/01/2007 Authors: Cai H; Dikalov S; Griendling KK; Harrison DG
  • Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
    Am J Physiol Cell Physiol Volume: 292 Page(s): C82 - C97
    01/01/2007 Authors: Mehta PK; Griendling KK
  • Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype.
    Arterioscler Thromb Vasc Biol Volume: 27 Page(s): 42 - 48
    01/01/2007 Authors: Clempus RE; Sorescu D; Dikalova AE; Pounkova L; Jo P; Sorescu GP; Schmidt HHH; Lassgue B; Griendling KK
  • Dual regulation of actin dynamics by cofilin and SSH1L in PDGF-stimulated vascular smooth muscle cells
    CIRCULATION Volume: 114 Page(s): 156 - 156
    10/31/2006 Authors: San Martin A; Lassegue B; Williams H; Griendling KK
  • Nox4 mediates cardiac fibrosis while p47phox-based Nox2 is required for the inflammatory response to angiotensin II in murine cardiac Fibroblasts
    CIRCULATION Volume: 114 Page(s): 117 - 117
    10/31/2006 Authors: Cucoranu L; Chiribau CB; Clempus RE; Kitchel B; Sorescu GP; Griendling KK; Sorescu D
  • Modulation of vascular smooth muscle signaling by reactive oxygen species.
    Physiology (Bethesda) Volume: 21 Page(s): 269 - 280
    08/01/2006 Authors: Lyle AN; Griendling KK
  • Nox is playing with a full deck in vascular smooth muscle, a commentary on "Noxa1 is a central component of the smooth muscle NADPH oxidase in mice".
    Free Radic Biol Med Volume: 41 Page(s): 185 - 187
    07/15/2006 Authors: Lassgue B; Griendling KK
  • Reactive oxygen species signaling in vascular smooth muscle cells.
    Cardiovasc Res Volume: 71 Page(s): 216 - 225
    07/15/2006 Authors: Clempus RE; Griendling KK
  • PKC-delta-dependent activation of oxidative stress modulates proliferation induced by hyperglycemia in rat aortic smooth muscle cells
    DIABETES Volume: 55 Page(s): A175 - A175
    06/01/2006 Authors: Son SM; Kim BH; Kang YH; Kim YK; Griendling KK
  • Selective regulation of bone morphogenetic protein-4 by reactive oxygen species in type 2 diabetic mice: Relationship to NADPH oxidases
    Volume: 26 Page(s): E84 - E84
    05/01/2006 Authors: Martin AS; Du PF; Dikalova A; Aleman M; Jo H; Griendling KK
  • The effects of smooth muscle-targeted Nox1-overexpression in the development of hypoxia-mediated pulmonary hypertension
    Volume: 20 Page(s): A402 - A402
    03/06/2006 Authors: Reed AL; Griendling KK; Elms SC; Sutliff RL
  • RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response.
    Hypertension Volume: 47 Page(s): 238 - 244
    02/01/2006 Authors: Modlinger P; Chabrashvili T; Gill PS; Mendonca M; Harrison DG; Griendling KK; Li M; Raggio J; Wellstein A; Chen Y
  • Oxidative stress and diabetic cardiovascular complications.
    Free Radic Biol Med Volume: 40 Page(s): 183 - 192
    01/15/2006 Authors: Jay D; Hitomi H; Griendling KK
  • Lack of long-term protective effect of antioxidant/anti-inflammatory therapy in transplant-induced ischemia/reperfusion injury.
    Am J Nephrol Volume: 26 Page(s): 213 - 217
    01/01/2006 Authors: Tain Y-L; Muller V; Szabo A; Dikalova A; Griendling K; Baylis C
  • NADPH oxidases: new regulators of old functions.
    Antioxid Redox Signal Volume: 8 Page(s): 1443 - 1445
    01/01/2006 Authors: Griendling KK
  • Renin-angiotensin system (RAS) activation of NADPH oxidase in skeletal muscle from Ren-2 rats
    HYPERTENSION Volume: 46 Page(s): 868 - 868
    11/01/2005 Authors: Stump CS; Wei YZ; Morris EM; Clark SE; Farrario CM; Lassegue B; Griendling KK; Sowers JR
  • Deletion of p47phox subunit of NADPH oxidase in mice causes severe cardiac fibrosis in response to anglotensin II
    CIRCULATION Volume: 112 Page(s): U103 - U103
    10/25/2005 Authors: Shin JJ; Cucoranu I; Sorescu G; Griendling KK; Sorescu D
  • Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice.
    Circulation Volume: 112 Page(s): 2668 - 2676
    10/25/2005 Authors: Dikalova A; Clempus R; Lassgue B; Cheng G; McCoy J; Dikalov S; San Martin A; Lyle A; Weber DS; Weiss D
  • Renin-angiotensin system (RAS) activation of NADPH oxidase in skeletal muscle from Ren-2 rats
    HYPERTENSION Volume: 46 Page(s): 868 - 868
    10/01/2005 Authors: Stump CS; Wei YZ; Morris EM; Clark SE; Farrario CM; Griendling KK; Sowers JR
  • Vascular hypertrophy in angiotensin II-induced hypertension is mediated by vascular smooth muscle cell-derived H2O2.
    Hypertension Volume: 46 Page(s): 732 - 737
    10/01/2005 Authors: Zhang Y; Griendling KK; Dikalova A; Owens GK; Taylor WR
  • Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4.
    Free Radic Biol Med Volume: 39 Page(s): 381 - 391
    08/01/2005 Authors: Wendt MC; Daiber A; Kleschyov AL; Mlsch A; Sydow K; Schulz E; Chen K; Keaney JF; Lassgue B; Walter U
  • Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2.
    Mol Pharmacol Volume: 68 Page(s): 41 - 48
    07/01/2005 Authors: Haider UGB; Roos TU; Kontaridis MI; Neel BG; Sorescu D; Griendling KK; Vollmar AM; Dirsch VM
  • Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II.
    Arterioscler Thromb Vasc Biol Volume: 25 Page(s): 1142 - 1147
    06/01/2005 Authors: Taniyama Y; Hitomi H; Shah A; Alexander RW; Griendling KK
  • Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production.
    Am J Physiol Cell Physiol Volume: 288 Page(s): C899 - C905
    04/01/2005 Authors: Hwang J; Kleinhenz DJ; Lassgue B; Griendling KK; Dikalov S; Hart CM
  • Peroxisome proliferator-activated receptor gamma (PPAR gamma) ligands regulate endothelial superoxide production
    FASEB JOURNAL Volume: 19 Page(s): A1236 - A1236
    03/07/2005 Authors: Hwang J; Kleinhenz DJ; Lassegue B; Griendling KK; Dikalov S; Hart CM
  • ATVB in focus: redox mechanisms in blood vessels.
    Arterioscler Thromb Vasc Biol Volume: 25 Page(s): 272 - 273
    02/01/2005 Authors: Griendling KK
  • Regulation of vascular NAD(P)H oxidase activity by nitric oxide: Possible role of protein kinase G and intracellular calcium.
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 39 Page(s): S82 - S82
    01/01/2005 Authors: Bikineyeva A; Dikalova A; Harrison DG; Griendling KK; Dikalov S
  • Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice.
    Am J Physiol Heart Circ Physiol Volume: 288 Page(s): H7 - 12
    01/01/2005 Authors: Laude K; Cai H; Fink B; Hoch N; Weber DS; McCann L; Kojda G; Fukai T; Schmidt HHHW; Dikalov S
  • Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle.
    Am J Physiol Heart Circ Physiol Volume: 288 Page(s): H37 - H42
    01/01/2005 Authors: Weber DS; Rocic P; Mellis AM; Laude K; Lyle AN; Harrison DG; Griendling KK
  • Mechanism of high glucose-induced cell cycle progression in vascular smooth muscle cells
    Volume: 54 Page(s): A185 - A186
    01/01/2005 Authors: Son SM; Griendling KK
  • Nitric oxide inhibits of superoxide and H2O2 production in smooth muscle cels: Analysis of expression of NAD(P)H oxidase subunits
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 39 Page(s): S84 - S84
    01/01/2005 Authors: Dikalova A; Bikineyeva A; Harrison DG; Griendling KK; Dikalov S
  • Functional association of nox1 with p22phox in vascular smooth muscle cells.
    Free Radic Biol Med Volume: 37 Page(s): 1542 - 1549
    11/15/2004 Authors: Hanna IR; Hilenski LL; Dikalova A; Taniyama Y; Dikalov S; Lyle A; Quinn MT; Lassgue B; Griendling KK
  • Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase.
    J Biol Chem Volume: 279 Page(s): 45935 - 45941
    10/29/2004 Authors: Ambasta RK; Kumar P; Griendling KK; Schmidt HHHW; Busse R; Brandes RP
  • Nox4-derived reactive oxygen species are required for the differentiation of vascular smooth muscle cells
    CIRCULATION Volume: 110 Page(s): 157 - 157
    10/26/2004 Authors: Clempus RE; Sorescu D; Lassegue B; Dikalova A; Griendling KK
  • Increased vascular Nox4 and P22phox expression, oxidase activity and inflammation in db/db diabetic mice
    CIRCULATION Volume: 110 Page(s): 260 - 260
    10/26/2004 Authors: Du PF; Lassegue B; Jay DB; Griendling KK
  • A critical role for hydrogen peroxide (H2O2) in neointima formation induced by carotid ligation
    CIRCULATION Volume: 110 Page(s): 259 - 259
    10/26/2004 Authors: Zhang Y; Griendling KK; Taylor WR
  • Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a Nox1-based NADPH oxidase
    CIRCULATION Volume: 110 Page(s): 90 - 90
    10/26/2004 Authors: Sorescu GP; Tressel SL; Song H; Hwang J; Dikalov S; Smith DA; Boyd NL; Platt MO; Lassegue B; Griendling KK
  • Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase.
    Circ Res Volume: 95 Page(s): 773 - 779
    10/15/2004 Authors: Sorescu GP; Song H; Tressel SL; Hwang J; Dikalov S; Smith DA; Boyd NL; Platt MO; Lassgue B; Griendling KK
  • Reactive oxygen species in hypertension; An update.
    Am J Hypertens Volume: 17 Page(s): 852 - 860
    09/01/2004 Authors: Lassgue B; Griendling KK
  • Oxidative stress and diabetic vascular complications.
    Curr Diab Rep Volume: 4 Page(s): 247 - 252
    08/01/2004 Authors: Son SM; Whalin MK; Harrison DG; Taylor WR; Griendling KK
  • Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells.
    Am J Physiol Cell Physiol Volume: 287 Page(s): C494 - C499
    08/01/2004 Authors: Taniyama Y; Ushio-Fukai M; Hitomi H; Rocic P; Kingsley MJ; Pfahnl C; Weber DS; Alexander RW; Griendling KK
  • C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils.
    Hypertension Volume: 43 Page(s): 1246 - 1251
    06/01/2004 Authors: Wyche KE; Wang SS; Griendling KK; Dikalov SI; Austin H; Rao S; Fink B; Harrison DG; Zafari AM
  • Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration.
    Circ Res Volume: 94 Page(s): 1219 - 1226
    05/14/2004 Authors: Weber DS; Taniyama Y; Rocic P; Seshiah PN; Dechert MA; Gerthoffer WT; Griendling KK
  • Novel NAD(P)H oxidases in the cardiovascular system.
    Heart Volume: 90 Page(s): 491 - 493
    05/01/2004 Authors: Griendling KK
  • Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells.
    Arterioscler Thromb Vasc Biol Volume: 24 Page(s): 677 - 683
    04/01/2004 Authors: Hilenski LL; Clempus RE; Quinn MT; Lambeth JD; Griendling KK
  • Reactive oxygen species facilitate vascular hypertrophy in mice overexpressing p22phox
    FASEB JOURNAL Volume: 18 Page(s): A1107 - A1107
    03/24/2004 Authors: Weber DS; Rocic P; Mellis AM; Lyle AN; Harrison DG; Griendling KK
  • Attenuation of Angiotensin II-induced hypertrophy in transgenic mice overexpressing catalase in vascular smooth muscle cells
    FASEB JOURNAL Volume: 18 Page(s): A956 - A956
    03/24/2004 Authors: Zhang Y; Griendling KK; Taylor RW
  • Thrombin: beyond coagulation.
    J Mol Cell Cardiol Volume: 36 Page(s): 13 - 15
    01/01/2004 Authors: Weber DS; Griendling KK
  • The antioxidant tempol attenuates Ang II induced oxidative stress, hypertension and hypertrophy in mice overexpressing Nox1 in smooth muscle cells
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 37 Page(s): S34 - S34
    01/01/2004 Authors: Dikalova A; Dikalov S; Lassegue B; Clempus R; San Martin A; Lyle A; Cheng GJ; Lambeth D; Owens G; Griendling K
  • Nitric oxide attenuates angiotensin II-mediated superoxide production in smooth muscle cells: Possible role of nitrosation of NAD(P)H oxidase
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 37 Page(s): S80 - S80
    01/01/2004 Authors: Dikalov S; Dikalova A; Harrison D; Griendling K
  • Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression: implication for native LDL oxidation.
    Circ Res Volume: 93 Page(s): 1225 - 1232
    12/12/2003 Authors: Hwang J; Ing MH; Salazar A; Lassgue B; Griendling K; Navab M; Sevanian A; Hsiai TK
  • Reactive oxygen species in the vasculature: molecular and cellular mechanisms.
    Hypertension Volume: 42 Page(s): 1075 - 1081
    12/01/2003 Authors: Taniyama Y; Griendling KK
  • Redox control of growth factor signaling in heart, lung, and circulation.
    Antioxid Redox Signal Volume: 5 Page(s): 689 - 690
    12/01/2003 Authors: Suzuki YJ; Griendling KK
  • Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion.
    J Biol Chem Volume: 278 Page(s): 47291 - 47298
    11/21/2003 Authors: Hwang J; Saha A; Boo YC; Sorescu GP; McNally JS; Holland SM; Dikalov S; Giddens DP; Griendling KK; Harrison DG
  • Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions.
    Mol Cell Biol Volume: 23 Page(s): 8019 - 8029
    11/01/2003 Authors: Taniyama Y; Weber DS; Rocic P; Hilenski L; Akers ML; Park J; Hemmings BA; Alexander RW; Griendling KK
  • Direct interaction of the novel nox proteins with p22phox for the formation of a radical generating NADPH oxidase
    CIRCULATION Volume: 108 Page(s): 46 - 46
    10/28/2003 Authors: Ambasta RK; Schmidt HH; Griendling KK; Brandes RP
  • Modulation of strain-mediated PAI-1 gene expression in vascular smooth muscle cells by cGMP-Elevating agents: Role of protein kinases A and G
    CIRCULATION Volume: 108 Page(s): 19 - 19
    10/28/2003 Authors: Agahtehrani A; Whalin M; Doran D; Griendling KK; Taylor WR
  • A molecular mechanism of angiotensin II-induced insulin resistance
    CIRCULATION Volume: 108 Page(s): 203 - 204
    10/28/2003 Authors: Taniyama Y; Shah AD; Alexander RW; Griendling KK
  • Oxidative stress and cardiovascular injury: Part II: animal and human studies.
    Circulation Volume: 108 Page(s): 2034 - 2040
    10/28/2003 Authors: Griendling KK; FitzGerald GA
  • Oscillatory shear stress stimulates endothelial cell production of superoxide from p47phox dependent NAD(P)H oxidases leading to monocyte adhesion
    CIRCULATION Volume: 108 Page(s): 201 - 201
    10/28/2003 Authors: Saha A; Hwang J; Boo YC; McNally JS; Harrison DG; Griendling KK; Dikalov S; Jo H
  • Nox1 overexpression in mice enhances AngII-Induced superoxide production and hypertension
    CIRCULATION Volume: 108 Page(s): 45 - 46
    10/28/2003 Authors: Dikalova A; Sutcliffe D; Dikalov S; Lassegue B; Weber D; Rocic P; Cheng G; Lambeth D; Owens G; Griendling K
  • Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS.
    Circulation Volume: 108 Page(s): 1912 - 1916
    10/21/2003 Authors: Griendling KK; FitzGerald GA
  • Reactive oxygen species sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells.
    J Biol Chem Volume: 278 Page(s): 36973 - 36979
    09/19/2003 Authors: Rocic P; Seshiah P; Griendling KK
  • The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases.
    Trends Pharmacol Sci Volume: 24 Page(s): 471 - 478
    09/01/2003 Authors: Cai H; Griendling KK; Harrison DG
  • The yin/yang of superoxide dismutase mimetics: potential cardiovascular therapies?
    Br J Pharmacol Volume: 139 Page(s): 1059 - 1060
    07/01/2003 Authors: Weber DS; Griendling KK
  • Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species.
    J Biol Chem Volume: 278 Page(s): 22901 - 22907
    06/20/2003 Authors: Fries DM; Paxinou E; Themistocleous M; Swanberg E; Griendling KK; Salvemini D; Slot JW; Heijnen HFG; Hazen SL; Ischiropoulos H
  • Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease.
    J Renin Angiotensin Aldosterone Syst Volume: 4 Page(s): 51 - 61
    06/01/2003 Authors: Harrison DG; Cai H; Landmesser U; Griendling KK
  • Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.
    J Biol Chem Volume: 278 Page(s): 19634 - 19641
    05/30/2003 Authors: Goubaeva F; Ghosh M; Malik S; Yang J; Hinkle PM; Griendling KK; Neubig RR; Smrcka AV
  • Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells.
    Mol Pharmacol Volume: 63 Page(s): 925 - 932
    04/01/2003 Authors: Haider UGB; Sorescu D; Griendling KK; Vollmar AM; Dirsch VM
  • Pyk2-dependent tyrosine phsphorylation of PDK1 mediates cell spreading
    FASEB JOURNAL Volume: 17 Page(s): A1351 - A1351
    03/17/2003 Authors: Taniyama Y; Weber DS; Rocic P; Hilenski L; Akers ML; Park J; Hemmings BA; Alexander RW; Griendling KK
  • The role of intracellular H2O2 in AngII-induced VSMC growth
    FASEB JOURNAL Volume: 17 Page(s): A371 - A371
    03/14/2003 Authors: Zhang Y; Griendling KK; Taylor WR
  • Role of oxidative stress in atherosclerosis.
    Am J Cardiol Volume: 91 Page(s): 7A - 11A
    02/06/2003 Authors: Harrison D; Griendling KK; Landmesser U; Hornig B; Drexler H
  • Regulation of eNOS protein expression and function in vivo by hydrogen peroxide
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 35 Page(s): S85 - S85
    01/01/2003 Authors: Laude K; Cai H; Fink B; McCann L; Gamez G; Griendling K; Harrison D
  • Role of Nox1 and p22phox in the production of superoxide and hydrogen peroxide by vascular smooth muscle NADPH oxidases
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 35 Page(s): S25 - S25
    01/01/2003 Authors: Dikalova A; Dikalov S; Hanna I; Lassegue B; Sutcliffe D; Griendling K
  • Modulation of NAD(P)H oxidase activity by nitric oxide: Role of heme nitrosylation and cysteine nitrosation
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 35 Page(s): S82 - S83
    01/01/2003 Authors: Dikalov S; Dikalova A; Harrison D; Griendling K
  • NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling.
    Antioxid Redox Signal Volume: 4 Page(s): 899 - 914
    12/01/2002 Authors: Hanna IR; Taniyama Y; Szcs K; Rocic P; Griendling KK
  • Role of Rho kinase in coupling Rac1-dependent NAD(P)H oxidase and focal adhesions in angiotensin II signaling
    CIRCULATION Volume: 106 Page(s): 260 - 260
    11/05/2002 Authors: Ushio-Fukai M; Ma YX; Hilenski LL; Seshiah P; Griendling KK; Alexander RW
  • NAD(P)H oxidase subunits nox1 and nox4 are differentially localized in the membrane and in focal adhesions in vascular smooth muscle cells
    CIRCULATION Volume: 106 Page(s): 283 - 283
    11/05/2002 Authors: Hilenski LL; Clempus RE; Griendling KK
  • Redox sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells
    CIRCULATION Volume: 106 Page(s): 51 - 51
    11/05/2002 Authors: Rocic P; Griendling KK
  • Src-dependent migration of vascular smooth muscle cells by PDGF is reactive oxygen species dependent
    CIRCULATION Volume: 106 Page(s): 260 - 260
    11/05/2002 Authors: Weber D; Seshiah P; Taniyama Y; Griendling KK
  • Differential expression of the NAD(P)H oxidase subunits Nox1 and Nox4 in diabetes mellitus
    CIRCULATION Volume: 106 Page(s): 51 - 51
    11/05/2002 Authors: Wendt MC; Lassegue B; Schulz E; Griendling KK; Munzel T
  • Nox1 binds p22phox to form a functional oxidase in vascular smooth muscle cells (VSMCs)
    CIRCULATION Volume: 106 Page(s): 164 - 164
    11/05/2002 Authors: Hanna IR; Dikalova A; Hilenski L; Quinn MT; Griendling KK
  • Mechanism of hydrogen peroxide-induced cell cycle arrest in vascular smooth muscle.
    Antioxid Redox Signal Volume: 4 Page(s): 845 - 854
    10/01/2002 Authors: Deshpande NN; Sorescu D; Seshiah P; Ushio-Fukai M; Akers M; Yin Q; Griendling KK
  • Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells.
    Mol Pharmacol Volume: 62 Page(s): 772 - 777
    10/01/2002 Authors: Haider UGB; Sorescu D; Griendling KK; Vollmar AM; Dirsch VM
  • Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators.
    Circ Res Volume: 91 Page(s): 406 - 413
    09/06/2002 Authors: Seshiah PN; Weber DS; Rocic P; Valppu L; Taniyama Y; Griendling KK
  • The A640G and C242T p22(phox) polymorphisms in patients with coronary artery disease.
    Antioxid Redox Signal Volume: 4 Page(s): 675 - 680
    08/01/2002 Authors: Zafari AM; Davidoff MN; Austin H; Valppu L; Cotsonis G; Lassgue B; Griendling KK
  • Regulated expression of Nox1 (NADPH oxidase1) in models of altered intestinal cell growth: Keratinocyte growth factor increases Nox 1 messenger RNA and superoxide production in human intestinal epithelial cells.
    GASTROENTEROLOGY Volume: 122 Page(s): A97 - A97
    04/01/2002 Authors: Gu LH; Griendling KK; Dikalov SI; Lassegue BP; Jones DP; Lambeth JD; Ziegler TR
  • Superoxide production and expression of nox family proteins in human atherosclerosis.
    Circulation Volume: 105 Page(s): 1429 - 1435
    03/26/2002 Authors: Sorescu D; Weiss D; Lassgue B; Clempus RE; Szcs K; Sorescu GP; Valppu L; Quinn MT; Lambeth JD; Vega JD
  • Differential phosphorylation of eNOS at Ser(116), Thr(497), Ser(635) and Ser(1179) in response to mechanical and humoral stimuli in endothelial cells
    FASEB JOURNAL Volume: 16 Page(s): A853 - A853
    03/22/2002 Authors: Boo YC; Hwang J; Skyes M; Griendling K; Jo HJ; Coulter WH
  • Reactive oxygen species modulate platelet-derived growth factor (PDGF) induced migration of vascular smooth muscle cells
    FASEB JOURNAL Volume: 16 Page(s): A1135 - A1136
    03/22/2002 Authors: Weber DS; Griendling KK
  • Effects of angiotensin II infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling.
    Circ Res Volume: 90 Page(s): E58 - E65
    03/08/2002 Authors: Mollnau H; Wendt M; Szcs K; Lassgue B; Schulz E; Oelze M; Li H; Bodenschatz M; August M; Kleschyov AL
  • Resveratrol reduces angiotensin II-induced hypertrophy in rat vascular smooth muscle cells in part by interfering with PKB/Akt and Erk 1/2
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Volume: 365 Page(s): R66 - R66
    03/01/2002 Authors: Haider UGB; Sorescu D; Griendling KK; Vollmar AM; Dirsch VM
  • Out phoxing the endothelium: what's left without p47?
    Circ Res Volume: 90 Page(s): 123 - 124
    02/08/2002 Authors: Lassgue B; Griendling KK
  • The role of NOX 1 subunit of NADPH oxidase overexpression in superoxide production, blood pressure and hypertrophy development in mice
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 33 Page(s): S351 - S351
    01/01/2002 Authors: Dikalova AE; Cheng GJ; Lambeth D; Owens G; Weber D; Rocic P; Dikalov S; Griendling K
  • Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury.
    Arterioscler Thromb Vasc Biol Volume: 22 Page(s): 21 - 27
    01/01/2002 Authors: Szcs K; Lassgue B; Sorescu D; Hilenski LL; Valppu L; Couse TL; Wilcox JN; Quinn MT; Lambeth JD; Griendling KK
  • Protein nitration pathways in immunostimulated vascular smooth muscle cells.
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 33 Page(s): S396 - S397
    01/01/2002 Authors: Fries DM; Blanchard-Fillion B; Lightfoot R; Salvemini D; Griendling KK; Ischiropoulos H
  • gp91phox homologues and the cardiovascular system
    Page(s): 79 - 86
    01/01/2002 Authors: Seshiah P; Hanna I; Griendling K
  • gp91(phox) homologues and the cardiovascular system
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 33 Page(s): S23 - S24
    01/01/2002 Authors: Griendling KK
  • Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure.
    Congest Heart Fail Volume: 8 Page(s): 132 - 140
    01/01/2002 Authors: Sorescu D; Griendling KK
  • Functional evaluation of nonphagocytic NAD(P)H oxidases.
    Methods Enzymol Volume: 353 Page(s): 220 - 233
    01/01/2002 Authors: Miller FJ; Griendling KK
  • Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling.
    J Biol Chem Volume: 276 Page(s): 48269 - 48275
    12/21/2001 Authors: Ushio-Fukai M; Hilenski L; Santanam N; Becker PL; Ma Y; Griendling KK; Alexander RW
  • Out, damned dot: studies of the NADPH oxidase in atherosclerosis.
    J Clin Invest Volume: 108 Page(s): 1423 - 1424
    11/01/2001 Authors: Griendling KK; Harrison DG
  • The C242T p22phox polymorphism of the NADPH oxidase is associated with reduced superoxide production in human neutrophils
    CIRCULATION Volume: 104 Page(s): 40 - 40
    10/23/2001 Authors: Wyche KE; Griendling KK; Dikalov SI; Austin H; Sorescu D; Harrison DG; Zafarl AM
  • Upstream mediators of angiotensin II activation of the vascular smooth muscle NAD(P)H oxidase.
    CIRCULATION Volume: 104 Page(s): 41 - 41
    10/23/2001 Authors: Seshiah PN; Sorescu D; Dikalov S; Griendling KK
  • Redox-sensitivity of tyrosine phosphorylated caveolin localized to focal adhesions in vascular smooth muscle cells
    CIRCULATION Volume: 104 Page(s): 71 - 71
    10/23/2001 Authors: Hilenski LL; Ushio-Fukai M; Akers ML; Alexander RW; Griendling KK
  • Angiotensin II regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK-1) in vascular smooth muscle cells
    CIRCULATION Volume: 104 Page(s): 224 - 224
    10/23/2001 Authors: Taniyama Y; Alexander RW; Akers ML; Griendling KK
  • Expression of the NAD(P)H oxidase subunits in human coronary arteries
    CIRCULATION Volume: 104 Page(s): 41 - 41
    10/23/2001 Authors: Sorescu D; Weiss D; Lassegue B; Szocs K; Vega JD; Taylor WR; Griendling KK
  • New ESR techniques for quantitative measurements of angiotensin II stimulated superoxide radical and hydrogen peroxide formation in vascular smooth muscle cells.
    CIRCULATION Volume: 104 Page(s): 70 - 71
    10/23/2001 Authors: Dikalov SI; Seshiah P; Dikalova AE; Griendling KK
  • Differential upregulation of nox1, nox4 and p22phox following balloon injury: Evidence for diverse functions of vascular NAD(P)H oxidases in restenosis
    CIRCULATION Volume: 104 Page(s): 100 - 100
    10/23/2001 Authors: Szocs K; Lassegue B; Valppu L; Hilenski LL; Sorescu D; Lambeth JD; Griendling KK
  • Adventitial cells do not contribute to neointimal mass after balloon angioplasty of the rat common carotid artery.
    Circulation Volume: 104 Page(s): 1591 - 1593
    10/02/2001 Authors: De Leon H; Ollerenshaw JD; Griendling KK; Wilcox JN
  • Inhibition of vascular cell growth by X-ray irradiation: comparison with gamma radiation and mechanism of action.
    Int J Radiat Oncol Biol Phys Volume: 50 Page(s): 485 - 493
    06/01/2001 Authors: Scott NA; Crocker IR; Yin Q; Sorescu D; Wilcox JN; Griendling KK
  • Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways.
    Circ Res Volume: 88 Page(s): 888 - 894
    05/11/2001 Authors: Lassgue B; Sorescu D; Szcs K; Yin Q; Akers M; Zhang Y; Grant SL; Lambeth JD; Griendling KK
  • Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells.
    Arterioscler Thromb Vasc Biol Volume: 21 Page(s): 489 - 495
    04/01/2001 Authors: Ushio-Fukai M; Griendling KK; Becker PL; Hilenski L; Halleran S; Alexander RW
  • Electron spin resonance characterization of the NAD(P)H oxidase in vascular smooth muscle cells.
    Free Radic Biol Med Volume: 30 Page(s): 603 - 612
    03/15/2001 Authors: Sorescu D; Somers MJ; Lassgue B; Grant S; Harrison DG; Griendling KK
  • Mechanisms underlying endothelial dysfunction in diabetes mellitus.
    Circ Res Volume: 88 Page(s): E14 - E22
    02/02/2001 Authors: Hink U; Li H; Mollnau H; Oelze M; Matheis E; Hartmann M; Skatchkov M; Thaiss F; Stahl RA; Warnholtz A
  • Resveratrol inhibits cell cycle progression, proliferation and Akt-kinase phosphorylation in VSMC
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 31 Page(s): S39 - S39
    01/01/2001 Authors: Haider U; Sorescu D; Griendling KK; Vollmar AM; Dirsch VM
  • Resveratrol inhibits cell cycle progression, proliferation and Akt-kinase phosphorylation in VSMC
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 31 Page(s): S31 - S31
    01/01/2001 Authors: Haider UGB; Sorescu D; Griendling KK; Vollmar AM; Dirsch VM
  • New rapid assay for NAD(P)H oxidase activity by ESR spectroscopy. Quantification of superoxide radical and H2O2 production.
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 31 Page(s): S69 - S69
    01/01/2001 Authors: Dikalov SI; Dikalova AE; Harrison DG; Griendling KK
  • NAD(P)H oxidases and their relevance to atherosclerosis.
    Trends Cardiovasc Med Volume: 11 Page(s): 124 - 131
    01/01/2001 Authors: Sorescu D; Szcs K; Griendling KK
  • The A640G p22phox polymorphism in coronary artery disease
    CIRCULATION Volume: 102 Page(s): 303 - 303
    10/31/2000 Authors: Zafari AM; Davidoff MN; Valppu L; Cotsonis GA; Lassegue B; Griendling KK
  • Hydrogen peroxide induces arrest of vascular smooth muscle in late G1: Role of cyclin A and cell cycle inhibitors p53 and p21
    CIRCULATION Volume: 102 Page(s): 167 - 167
    10/31/2000 Authors: Deshpande NN; Sorescu D; Ushio-Fukai M; Akers M; Yin QQ; Griendling K
  • A novel role for caveolin in redox-sensitive transactivation of EGF receptor by angiotensin II in vascular smooth muscle cells
    CIRCULATION Volume: 102 Page(s): 233 - 233
    10/31/2000 Authors: Ushio-Fukai M; Griendling KK; Zhu LP; Alexander RW
  • Localization of superoxide production and expression of the NAD(P)H oxidase subunit p22phox in human coronary artery
    CIRCULATION Volume: 102 Page(s): 301 - 301
    10/31/2000 Authors: Sorescu D; Daiana W; Vega JD; Griendling KK; Taylor WR
  • Nox-1, a novel gp91phox homologue, is upregulated in restenosis following balloon injury
    CIRCULATION Volume: 102 Page(s): 303 - 303
    10/31/2000 Authors: Szscs K; Lassegue B; Sorescu D; Weintraub NL; Miller FJ; Lambeth JD; Griendling KK
  • Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology.
    Arterioscler Thromb Vasc Biol Volume: 20 Page(s): 2175 - 2183
    10/01/2000 Authors: Griendling KK; Sorescu D; Lassgue B; Ushio-Fukai M
  • Reactive oxygen species as mediators of angiotensin II signaling.
    Regul Pept Volume: 91 Page(s): 21 - 27
    07/28/2000 Authors: Griendling KK; Ushio-Fukai M
  • NAD(P)H oxidase: role in cardiovascular biology and disease.
    Circ Res Volume: 86 Page(s): 494 - 501
    03/17/2000 Authors: Griendling KK; Sorescu D; Ushio-Fukai M
  • Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells.
    Mol Pharmacol Volume: 57 Page(s): 460 - 467
    03/01/2000 Authors: Grant SL; Lassgue B; Griendling KK; Ushio-Fukai M; Lyons PR; Alexander RW
  • Convergence of redox-sensitive and mitogen-activated protein kinase signaling pathways in tumor necrosis factor-alpha-mediated monocyte chemoattractant protein-1 induction in vascular smooth muscle cells.
    Arterioscler Thromb Vasc Biol Volume: 20 Page(s): 385 - 391
    02/01/2000 Authors: De Keulenaer GW; Ushio-Fukai M; Yin Q; Chung AB; Lyons PR; Ishizaka N; Rengarajan K; Taylor WR; Alexander RW; Griendling KK
  • Intravascular radiation inhibits cell proliferation and vascular remodeling after angioplasty by increasing the expression of p21 in adventitial myofibroblasts
    CIRCULATION Volume: 100 Page(s): 700 - 700
    11/02/1999 Authors: Wang HN; Griendling KK; Scott NA; Ting JY; Crocker IR; Wilcox JN
  • Cloning and characterization of a novel redox-sensitive transcription factor from aortic smooth muscle cells that binds to the promoter of monocyte chemotactic protein-1
    CIRCULATION Volume: 100 Page(s): 45 - 45
    11/02/1999 Authors: Chung AB; Deshpande N; Lassegue B; Yin QQ; Sorescu D; Alexander RW; Griendling KK
  • P65-mox, a novel gp91-phox analogue, participates in superoxide generation and cellular proliferation in vascular smooth muscle
    CIRCULATION Volume: 100 Page(s): 44 - 45
    11/02/1999 Authors: Lassegue B; Sorescu D; Chung AB; Yin QQ; Deshpande N; Lambeth JD; Griendling KK
  • Reactive oxygen species and cell cycle progression of vascular smooth muscle cells
    CIRCULATION Volume: 100 Page(s): 479 - 479
    11/02/1999 Authors: Sorescu D; Lassegue B; Chung AB; Grant SL; Griendling KK
  • Role of reactive oxygen species in angiotensin II-induced transactivation of epidermal growth factor receptor in vascular smooth muscle cells
    CIRCULATION Volume: 100 Page(s): 263 - 263
    11/02/1999 Authors: Ushio-Fukai M; Griendling KK; Becker PL; Alexander RW
  • Dual role of reactive oxygen species in vascular growth.
    Circ Res Volume: 85 Page(s): 562 - 563
    09/17/1999 Authors: Griendling KK; Harrison DG
  • Cell transformation by the superoxide-generating oxidase Mox1.
    Nature Volume: 401 Page(s): 79 - 82
    09/02/1999 Authors: Suh YA; Arnold RS; Lassegue B; Shi J; Xu X; Sorescu D; Chung AB; Griendling KK; Lambeth JD
  • Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells.
    J Biol Chem Volume: 274 Page(s): 22699 - 22704
    08/06/1999 Authors: Ushio-Fukai M; Alexander RW; Akers M; Yin Q; Fujio Y; Walsh K; Griendling KK
  • Modulation of extracellular superoxide dismutase expression by angiotensin II and hypertension.
    Circ Res Volume: 85 Page(s): 23 - 28
    07/09/1999 Authors: Fukai T; Siegfried MR; Ushio-Fukai M; Griendling KK; Harrison DG
  • Increased NADH-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin-angiotensin system.
    Circulation Volume: 99 Page(s): 2027 - 2033
    04/20/1999 Authors: Warnholtz A; Nickenig G; Schulz E; Macharzina R; Brsen JH; Skatchkov M; Heitzer T; Stasch JP; Griendling KK; Harrison DG
  • Angiotensin II regulates RGS expression in vascular smooth muscle cells.
    FASEB JOURNAL Volume: 13 Page(s): A797 - A797
    03/15/1999 Authors: Grant SL; Griendling KK; Lassegue B; Ushio-Fukai M; Alexander RW
  • Reactive oxygen species mediate transactivation of EGF receptor by angiotensin II in vascular cells
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 27 Page(s): S110 - S110
    01/01/1999 Authors: Ushio-Fukai M; Griendling KK; Becker PL; Alexander RW
  • Arachidonic acid metabolites mediate angiotensin II-induced NADH/NADPH oxidase activity and hypertrophy in vascular smooth muscle cells.
    Antioxid Redox Signal Volume: 1 Page(s): 167 - 179
    01/01/1999 Authors: Zafari AM; Ushio-Fukai M; Minieri CA; Akers M; Lassgue B; Griendling KK
  • Angiotensin II receptor coupling to phospholipase D is mediated by the betagamma subunits of heterotrimeric G proteins in vascular smooth muscle cells.
    Mol Pharmacol Volume: 55 Page(s): 142 - 149
    01/01/1999 Authors: Ushio-Fukai M; Alexander RW; Akers M; Lyons PR; Lassgue B; Griendling KK
  • A biochemical characterization of vascular myocyte NADPH/NADH oxidase using electron spin resonance
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 27 Page(s): S28 - S28
    01/01/1999 Authors: Sorescu D; Somers MJ; LassEgue B; Grant SL; Griendling KK
  • Requirement of reactive oxygen species for cell cycle progression in vascular smooth muscle cells
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 27 Page(s): S116 - S116
    01/01/1999 Authors: Sorescu D; LassEgue B; Chung AB; Grant SL; Griendling KK
  • The effect of 'soft' X-rays on the inhibition of vascular cell proliferation
    CIRCULATION Volume: 98 Page(s): 557 - 557
    10/27/1998 Authors: Scott NA; Crocker IR; Yin QQ; Ghavidal S; Moses A; Griendling KK
  • Caveolin-1 and caveolin-3 are regulated in rat aorta by hypertension and in cultured vascular smooth muscle by mechanical strain.
    CIRCULATION Volume: 98 Page(s): 536 - 536
    10/27/1998 Authors: Ishizaka N; Griendling KK; Guest TM; Mori I; Taylor R; Alexander WW
  • Critical role of reactive oxygen species in activating specific angiotensin II receptor signaling pathways in vascular smooth muscle cells
    CIRCULATION Volume: 98 Page(s): 220 - 220
    10/27/1998 Authors: Ushio-Fukai M; Alexander RW; Akers M; Griendling KK
  • Role of NADH/NADPH oxidase-derived H2O2 in angiotensin II-induced vascular hypertrophy.
    Hypertension Volume: 32 Page(s): 488 - 495
    09/01/1998 Authors: Zafari AM; Ushio-Fukai M; Akers M; Yin Q; Shah A; Harrison DG; Taylor WR; Griendling KK
  • Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation.
    Hypertension Volume: 32 Page(s): 459 - 466
    09/01/1998 Authors: Ishizaka N; Griendling KK; Lassgue B; Alexander RW
  • Temporal dispersion of activation of phospholipase C-beta1 and -gamma isoforms by angiotensin II in vascular smooth muscle cells. Role of alphaq/11, alpha12, and beta gamma G protein subunits.
    J Biol Chem Volume: 273 Page(s): 19772 - 19777
    07/31/1998 Authors: Ushio-Fukai M; Griendling KK; Akers M; Lyons PR; Alexander RW
  • Redox control of vascular smooth muscle proliferation.
    J Lab Clin Med Volume: 132 Page(s): 9 - 15
    07/01/1998 Authors: Griendling KK; Ushio-Fukai M
  • G-Protein binding domains of the angiotensin II AT1A receptors mapped with synthetic peptides selected from the receptor sequence.
    Biochem J Volume: 332 ( Pt 3) Page(s): 781 - 787
    06/15/1998 Authors: Kai H; Alexander RW; Ushio-Fukai M; Lyons PR; Akers M; Griendling KK
  • p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy.
    J Biol Chem Volume: 273 Page(s): 15022 - 15029
    06/12/1998 Authors: Ushio-Fukai M; Alexander RW; Akers M; Griendling KK
  • Endothelial dysfunction in hypertension
    JOURNAL OF HYPERTENSION Volume: 16 Page(s): S24 - S24
    06/01/1998 Authors: Alexander RW; Griendling KK; Taylor RW
  • Oscillatory and steady laminar shear stress differentially affect human endothelial redox state: role of a superoxide-producing NADH oxidase.
    Circ Res Volume: 82 Page(s): 1094 - 1101
    06/01/1998 Authors: De Keulenaer GW; Chappell DC; Ishizaka N; Nerem RM; Alexander RW; Griendling KK
  • Tumour necrosis factor alpha activates a p22phox-based NADH oxidase in vascular smooth muscle.
    Biochem J Volume: 329 ( Pt 3) Page(s): 653 - 657
    02/01/1998 Authors: De Keulenaer GW; Alexander RW; Ushio-Fukai M; Ishizaka N; Griendling KK
  • Modulation of vascular extracellular SOD expression by angiotensin II and hypertension
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 25 Page(s): S32 - S32
    01/01/1998 Authors: Harrison DG; Fukai T; Siegfried MR; Ushio-Fukai M; Griendling KK
  • Role of reactive oxygen species in AKT activation by angiotensin II in vascular smooth muscle
    FREE RADICAL BIOLOGY AND MEDICINE Volume: 25 Page(s): S86 - S86
    01/01/1998 Authors: Ushio-Fukai M; Alexander RW; Akers M; Griendling KK
  • G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension.
    J Biol Chem Volume: 272 Page(s): 32482 - 32488
    12/19/1997 Authors: Ishizaka N; Alexander RW; Laursen JB; Kai H; Fukui T; Oppermann M; Lefkowitz RJ; Lyons PR; Griendling KK
  • Oxidative stress and cardiovascular disease.
    Circulation Volume: 96 Page(s): 3264 - 3265
    11/18/1997 Authors: Griendling KK; Alexander RW
  • NADH/NADPH Oxidase and Vascular Function.
    Trends Cardiovasc Med Volume: 7 Page(s): 301 - 307
    11/01/1997 Authors: Griendling KK; Ushio-Fukai M
  • Oscillatory and steady laminar shear stress differentially affect endothelial redox state
    CIRCULATION Volume: 96 Page(s): 234 - 234
    10/21/1997 Authors: deKeulenaer GW; Chappell DC; Ishizaka N; Nerem RM; Alexander RW; Griendling KK
  • Caveolin-1 is regulated by angiotensin II in vascular smooth muscle cells
    CIRCULATION Volume: 96 Page(s): 249 - 249
    10/21/1997 Authors: Ishizaka N; Griendling KK; Lassegue B; Alexander RW
  • Fluid shear stress regulates caveolin expression in cultured human umbilical vein endothelial cells.
    CIRCULATION Volume: 96 Page(s): 267 - 267
    10/21/1997 Authors: Ishizaka N; Chappell DC; Dekeulenaur G; Nerem RM; Griendling KK; Alexander RW
  • G protein beta gamma subunits of heterotrimeric G proteins are involved in angiotensin II signaling linked to phospholipase C activation in cultured vascular smooth muscle cells
    CIRCULATION Volume: 96 Page(s): 1658 - 1658
    10/21/1997 Authors: Fukai MU; Griendling KK; Lyons PR; Akers ML; Alexander RW
  • Angiotensin II-induced hypertension increases heme oxygenase-1 expression in rat aorta.
    Circulation Volume: 96 Page(s): 1923 - 1929
    09/16/1997 Authors: Ishizaka N; de Len H; Laursen JB; Fukui T; Wilcox JN; De Keulenaer G; Griendling KK; Alexander RW
  • Vascular thrombin receptor regulation in hypertensive rats.
    Circ Res Volume: 80 Page(s): 838 - 844
    06/01/1997 Authors: Capers Q; Laursen JB; Fukui T; Rajagopalan S; Mori I; Lou P; Freeman BA; Berrington WR; Griendling KK; Harrison DG
  • Heme oxygenase-1 is regulated by angiotensin II in rat vascular smooth muscle cells.
    Hypertension Volume: 29 Page(s): 790 - 795
    03/01/1997 Authors: Ishizaka N; Griendling KK
  • Cyclic strain induces an oxidative stress in endothelial cells.
    Am J Physiol Volume: 272 Page(s): C421 - C427
    02/01/1997 Authors: Howard AB; Alexander RW; Nerem RM; Griendling KK; Taylor WR
  • p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats.
    Circ Res Volume: 80 Page(s): 45 - 51
    01/01/1997 Authors: Fukui T; Ishizaka N; Rajagopalan S; Laursen JB; Capers Q; Taylor WR; Harrison DG; de Leon H; Wilcox JN; Griendling KK
  • Angiotensin II signaling in vascular smooth muscle. New concepts.
    Hypertension Volume: 29 Page(s): 366 - 373
    01/01/1997 Authors: Griendling KK; Ushio-Fukai M; Lassgue B; Alexander RW
  • Signal transduction in vascular smooth muscle.
    J Hypertens Suppl Volume: 14 Page(s): S51 - S54
    12/01/1996 Authors: Alexander RW; Griendling KK
  • TNF-alpha activates a p22 phox-containing NADH oxidase in vascular smooth muscle cells
    CIRCULATION Volume: 94 Page(s): 249 - 249
    10/15/1996 Authors: DeKeulenaer GW; UshioFukai M; Ishizaka N; Alexander RW; Griendling KK
  • Heme oxygenase-1 is regulated in aortas from angiotensin II-induced hypertensive rats
    CIRCULATION Volume: 94 Page(s): 219 - 219
    10/15/1996 Authors: Ishizaka N; deLeon H; Fukui T; Wilcox JN; Alexander RW; Griendling KK
  • Angiotensin II increases intracellular NADH/NADPH oxidase-dependent hydrogen peroxide in cultured vascular smooth muscle cells
    CIRCULATION Volume: 94 Page(s): 1630 - 1630
    10/15/1996 Authors: Zafari AM; UshioFukai M; Howard AB; Harrison DG; Taylor WR; Griendling KK
  • Cyclic strain increases phospholipase A2 activity in endothelial cells
    CIRCULATION Volume: 94 Page(s): 2595 - 2595
    10/15/1996 Authors: Howard AB; Zafari AM; Griendling KK; Taylor WR
  • Redox-sensitive regulation of the vascular thrombin receptor in experimental hypertension and in cultured cells
    CIRCULATION Volume: 94 Page(s): 182 - 182
    10/15/1996 Authors: Capers Q; Laursen JB; Griendling KK; Berrington W; Freeman B; Nerem RM; Alexander RW; Taylor WR
  • p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells.
    J Biol Chem Volume: 271 Page(s): 23317 - 23321
    09/20/1996 Authors: Ushio-Fukai M; Zafari AM; Fukui T; Ishizaka N; Griendling KK
  • Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.
    J Clin Invest Volume: 97 Page(s): 1916 - 1923
    04/15/1996 Authors: Rajagopalan S; Kurz S; Mnzel T; Tarpey M; Freeman BA; Griendling KK; Harrison DG
  • Endothelial control of the cardiovascular system: recent advances.
    FASEB J Volume: 10 Page(s): 283 - 292
    02/01/1996 Authors: Griendling KK; Alexander RW
  • Prolonged exposure to agonist results in a reduction in the levels of the Gq/G11 alpha subunits in cultured vascular smooth muscle cells.
    Mol Pharmacol Volume: 49 Page(s): 96 - 104
    01/01/1996 Authors: Kai H; Fukui T; Lassgue B; Shah A; Minieri CA; Griendling KK
  • Angiotensin receptors and their therapeutic implications.
    Annu Rev Pharmacol Toxicol Volume: 36 Page(s): 281 - 306
    01/01/1996 Authors: Griendling KK; Lassgue B; Alexander RW
  • NADH OXIDASE ACTIVITY IN ANGIOTENSIN-II MEDIATED HYPERTENSION
    CIRCULATION Volume: 92 Page(s): 1862 - 1862
    10/15/1995 Authors: RAJAGOPALAN S; KURZ S; GRIENDLING K; HARRISON D
  • G-PROTEIN BINDING SEQUENCES OF THE ANGIOTENSIN-II AT(1R) RECEPTOR IN RAT VASCULAR SMOOTH-MUSCLE GELS
    CIRCULATION Volume: 92 Page(s): 824 - 824
    10/15/1995 Authors: KAI H; ALEXANDER RW; GRIENDLING KK
  • NADPH OXIDASE ACTIVITY AND CYTOCHROME B(558) ALPHA-SUBUNIT MESSENGER-RNA EXPRESSION ARE INCREASED IN AORTAS FROM HYPERTENSIVE RATS
    CIRCULATION Volume: 92 Page(s): 1098 - 1098
    10/15/1995 Authors: FUKUI T; RAJAGOPALAN S; HARRISON DG; LASSEGUE B; GRIENDLING KK
  • EFFECT OF ANGIOTENSIN-II INFUSION AND HYPERTENSION ON THROMBIN RECEPTOR MESSENGER-RNA CONTENT OF RAT AORTAE
    CIRCULATION Volume: 92 Page(s): 1345 - 1345
    10/15/1995 Authors: CAPERS Q; RAJAGOPALAN S; FUKUI T; GRIENDLING KK; RUNGE MS; TAYLOR WR
  • Cytochrome b-558 alpha-subunit cloning and expression in rat aortic smooth muscle cells.
    Biochim Biophys Acta Volume: 1231 Page(s): 215 - 219
    10/10/1995 Authors: Fukui T; Lassgue B; Kai H; Alexander RW; Griendling KK
  • Angiotensin II down-regulates the vascular smooth muscle AT1 receptor by transcriptional and post-transcriptional mechanisms: evidence for homologous and heterologous regulation.
    Mol Pharmacol Volume: 48 Page(s): 601 - 609
    10/01/1995 Authors: Lassgue B; Alexander RW; Nickenig G; Clark M; Murphy TJ; Griendling KK
  • Relationship of phospholipase C- and phospholipase D-mediated phospholipid remodeling pathways to respiratory burst activation in human neutrophils stimulated by Candida albicans hyphae.
    J Leukoc Biol Volume: 57 Page(s): 842 - 850
    06/01/1995 Authors: Meshulam T; Billah MM; Eckel S; Griendling KK; Diamond RD
  • ANGIOTENSIN-II INCREASES VASCULAR SUPEROXIDE PRODUCTION IN-VIVO
    FASEB JOURNAL Volume: 9 Page(s): A315 - A315
    03/09/1995 Authors: RAJAGOPALAN S; GRIENDLING KK; HARRISON DG
  • Agonist-induced phosphorylation of the vascular type 1 angiotensin II receptor.
    Hypertension Volume: 24 Page(s): 523 - 527
    10/01/1994 Authors: Kai H; Griendling KK; Lassgue B; Ollerenshaw JD; Runge MS; Alexander RW
  • Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.
    Circ Res Volume: 74 Page(s): 1141 - 1148
    06/01/1994 Authors: Griendling KK; Minieri CA; Ollerenshaw JD; Alexander RW
  • Angiotensin II stimulates phosphorylation of high-molecular-mass cytosolic phospholipase A2 in vascular smooth-muscle cells.
    Biochem J Volume: 299 ( Pt 1) Page(s): 197 - 201
    04/01/1994 Authors: Rao GN; Lassgue B; Alexander RW; Griendling KK
  • Angiotensin II induces phosphorylation of eukaryotic protein synthesis initiation factor 4E in vascular smooth muscle cells.
    J Biol Chem Volume: 269 Page(s): 7180 - 7184
    03/11/1994 Authors: Rao GN; Griendling KK; Frederickson RM; Sonenberg N; Alexander RW
  • Endothelin A and B receptors are down-regulated in the hearts of hypertensive rats.
    Am J Med Sci Volume: 307 Page(s): 222 - 227
    03/01/1994 Authors: Hayzer DJ; Cicila G; Cockerham C; Griendling KK; Delafontaine P; Ng SC; Runge MS
  • RECRUITMENT OF NEUTROPHILS AND RELEASE OF MYELOPEROXIDASE INTO THE VESSEL WALL AFTER VASCULAR INJURY IN THE RAT AND BABOON
    FASEB JOURNAL Volume: 8 Page(s): A319 - A319
    03/01/1994 Authors: SUBRAMANIAN RR; OLLERENSHAW J; GRIENDLING K; KELLY A; HUBER AR; HARKER LA; WILCOX JN
  • Angiotensin II receptor pharmacology.
    Adv Pharmacol Volume: 28 Page(s): 269 - 306
    01/01/1994 Authors: Griendling KK; Lassgue B; Murphy TJ; Alexander RW
  • The angiotensin (AT1) receptor.
    Semin Nephrol Volume: 13 Page(s): 558 - 566
    11/01/1993 Authors: Griendling KK; Alexander RW
  • Hydrogen peroxide stimulates transcription of c-jun in vascular smooth muscle cells: role of arachidonic acid.
    Oncogene Volume: 8 Page(s): 2759 - 2764
    10/01/1993 Authors: Rao GN; Lassgue B; Griendling KK; Alexander RW
  • ANGIOTENSIN-II PHOSPHORYLATES THE AT(1)-RECEPTOR ON BOTH SERINE AND TYROSINE IN RAT AORTIC VASCULAR SMOOTH-MUSCLE CELLS
    CIRCULATION Volume: 88 Page(s): 280 - 280
    10/01/1993 Authors: KAI H; GRIENDLING KK; OLLERENSHAW JD; LASSEGUE B; ALEXANDER RW
  • ANGIOTENSIN-II INDUCES PHOSPHORYLATION OF A 28 KDA MESSENGER-RNA CAP-BINDING PROTEIN, EIF-4E, IN VASCULAR SMOOTH-MUSCLE CELLS
    CIRCULATION Volume: 88 Page(s): 141 - 141
    10/01/1993 Authors: RAO GN; GRIENDLING K; FREDERICKSON RM; SONENBERG N; ALEXANDER RW
  • The vascular angiotensin (AT1) receptor.
    Thromb Haemost Volume: 70 Page(s): 188 - 192
    07/01/1993 Authors: Griendling KK; Lassgue B; Alexander RW
  • VASCULAR SMOOTH-MUSCLE CELL THROMBIN RECEPTOR ACTIVATION AND DESENSITIZATION
    THROMBOSIS AND HAEMOSTASIS Volume: 69 Page(s): 1210 - 1210
    06/30/1993 Authors: WICK KL; GRIENDLING KK; RUNGE MS
  • Phosphatidylcholine is a major source of phosphatidic acid and diacylglycerol in angiotensin II-stimulated vascular smooth-muscle cells.
    Biochem J Volume: 292 ( Pt 2) Page(s): 509 - 517
    06/01/1993 Authors: Lassgue B; Alexander RW; Clark M; Akers M; Griendling KK
  • Molecular biology of the renin-angiotensin system.
    Circulation Volume: 87 Page(s): 1816 - 1828
    06/01/1993 Authors: Griendling KK; Murphy TJ; Alexander RW
  • Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C.
    Nucleic Acids Res Volume: 21 Page(s): 1259 - 1263
    03/11/1993 Authors: Rao GN; Lassgue B; Griendling KK; Alexander RW; Berk BC
  • ANGIOTENSIN-II STIMULATES SUPEROXIDE PRODUCTION IN CULTURED VASCULAR SMOOTH-MUSCLE CELLS
    FASEB JOURNAL Volume: 7 Page(s): A1 - A1
    02/19/1993 Authors: GRIENDLING KK; OLLERENSHAW JD; MINIERI CA; ALEXANDER RW
  • Angiotensin-II-and endothelin-induced protein phosphorylation in cultured vascular smooth muscle cells.
    J Vasc Res Volume: 30 Page(s): 241 - 249
    01/01/1993 Authors: Tsuda T; Griendling KK; Ollerenshaw JD; Lassgue B; Alexander RW
  • PHOSPHOLIPASE D ACTIVITY IN PROLIFERATING VASCULAR SMOOTH-MUSCLE AND NEOINTIMA IS ATTENUATED BY N-ACETYLCYSTEINE
    CIRCULATION Volume: 86 Page(s): 759 - 759
    10/01/1992 Authors: OLLERENSHAW JD; ALEXANDER RW; MINIERI C; GRIENDLING KK
  • REGULATION OF ANGIOTENSIN-II RECEPTOR EXPRESSION IN VASCULAR SMOOTH-MUSCLE CELLS
    FASEB JOURNAL Volume: 6 Page(s): A1859 - A1859
    02/28/1992 Authors: LASSEGUE B; GRIENDLING KK; MURPHY TJ; ALEXANDER RW
  • Characterization of phosphatidylinositol-specific phospholipase C from cultured vascular smooth muscle cells.
    J Biol Chem Volume: 266 Page(s): 15498 - 15504
    08/15/1991 Authors: Griendling KK; Taubman MB; Akers M; Mendlowitz M; Alexander RW
  • Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor.
    Nature Volume: 351 Page(s): 233 - 236
    05/16/1991 Authors: Murphy TJ; Alexander RW; Griendling KK; Runge MS; Bernstein KE
  • Angiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells. Regulation and localization.
    Biochem J Volume: 276 ( Pt 1) Page(s): 19 - 25
    05/15/1991 Authors: Lassgue B; Alexander RW; Clark M; Griendling KK
  • Thrombin-stimulated events in cultured vascular smooth-muscle cells.
    Biochem J Volume: 274 ( Pt 3) Page(s): 799 - 805
    03/15/1991 Authors: Berk BC; Taubman MB; Griendling KK; Cragoe EJ; Fenton JW; Brock TA
  • INTRACELLULAR SIGNALING IN ARTERIES AND VASCULAR SMOOTH-MUSCLE CELLS IN CULTURE
    Volume: 974 Page(s): 73 - 76
    01/01/1991 Authors: OLLERENSHAW JD; LASSEGUE B; ALEXANDER RW; GRIENDLING KK
  • Muscarinic cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a role of two guanine-nucleotide-binding proteins.
    Biochem J Volume: 271 Page(s): 437 - 442
    10/15/1990 Authors: Barnett JV; Shamah SM; Lassegue B; Griendling KK; Galper JB
  • Development of muscarinic-cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a switch in guanine-nucleotide-binding protein coupling.
    Biochem J Volume: 271 Page(s): 443 - 448
    10/15/1990 Authors: Barnett JV; Shamah SM; Lassegue B; Griendling KK; Galper JB
  • Thrombin signal transduction mechanisms in rat vascular smooth muscle cells. Calcium and protein kinase C-dependent and -independent pathways.
    J Biol Chem Volume: 265 Page(s): 17334 - 17340
    10/05/1990 Authors: Berk BC; Taubman MB; Cragoe EJ; Fenton JW; Griendling KK
  • PROTEIN-KINASE-C ACTIVITY AND PROTEIN-PHOSPHORYLATION IN RESISTANCE VESSELS
    CIRCULATION Volume: 82 Page(s): 407 - 407
    10/01/1990 Authors: OLLERENSHAW JD; ALEXANDER RW; GRIENDLING KK
  • REGULATION OF ANGIOTENSIN II-INDUCED PHOSPHATIDYLCHOLINE HYDROLYSIS IN VASCULAR SMOOTH-MUSCLE
    CIRCULATION Volume: 82 Page(s): 409 - 409
    10/01/1990 Authors: LASSEGUE B; ALEXANDER RW; CLARK M; GRIENDLING KK
  • PRESSURE INDUCES INSULIN-LIKE GROWTH FACTOR-I SECRETION BY ENDOTHELIAL-CELLS
    HYPERTENSION Volume: 16 Page(s): 335 - 335
    09/01/1990 Authors: TAYLOR WR; DELAFONTAINE P; GRIENDLING KK; NEREM RM; ALEXANDER RW
  • Cholera toxin modulation of angiotensin II-stimulated inositol phosphate production in cultured vascular smooth muscle cells.
    Biochem J Volume: 265 Page(s): 799 - 807
    02/01/1990 Authors: Socorro L; Alexander RW; Griendling KK
  • Angiotensin II stimulation of vascular smooth muscle cells. Secondary signalling mechanisms.
    Am J Hypertens Volume: 2 Page(s): 659 - 665
    08/01/1989 Authors: Griendling KK; Tsuda T; Berk BC; Alexander RW
  • Endothelin stimulates diacylglycerol accumulation and activates protein kinase C in cultured vascular smooth muscle cells.
    J Biol Chem Volume: 264 Page(s): 8237 - 8240
    05/15/1989 Authors: Griendling KK; Tsuda T; Alexander RW
  • Angiotensin II stimulation of vascular smooth muscle.
    J Cardiovasc Pharmacol Volume: 14 Suppl 6 Page(s): S27 - S33
    01/01/1989 Authors: Griendling KK; Tsuda T; Berk BC; Alexander RW
  • Angiotensin II stimulates vimentin phosphorylation via a Ca2+-dependent, protein kinase C-independent mechanism in cultured vascular smooth muscle cells.
    J Biol Chem Volume: 263 Page(s): 19758 - 19763
    12/25/1988 Authors: Tsuda T; Griendling KK; Alexander RW
  • Effects of glucocorticoids on Na+/H+ exchange and growth in cultured vascular smooth muscle cells.
    J Cell Physiol Volume: 137 Page(s): 391 - 401
    12/01/1988 Authors: Berk BC; Vallega G; Griendling KK; Gordon JB; Cragoe EJ; Canessa M; Alexander RW
  • GTP gamma S loading of endothelial cells stimulates phospholipase C and uncouples ATP receptors.
    Am J Physiol Volume: 255 Page(s): C667 - C673
    11/01/1988 Authors: Brock TA; Dennis PA; Griendling KK; Diehl TS; Davies PF
  • Evidence that Na+/H+ exchange regulates angiotensin II-stimulated diacylglycerol accumulation in vascular smooth muscle cells.
    J Biol Chem Volume: 263 Page(s): 10620 - 10624
    08/05/1988 Authors: Griendling KK; Berk BC; Alexander RW
  • BRADYKININ RECEPTORS ARE COUPLED TO MITOGENIC AND CONSTRICTOR PATHWAYS IN VASCULAR SMOOTH-MUSCLE CELLS
    CLINICAL RESEARCH Volume: 36 Page(s): A269 - A269
    04/01/1988 Authors: COLUCCI WS; AKERS M; SPERTI G; GRIENDLING KK
  • SENSITIVITY OF MUSCARINIC CHOLINERGIC STIMULATION OF INOSITOL TRISPHOSPHATE PRODUCTION TO PERTUSSIS TOXIN IN CULTURED EMBRYONIC CHICK ATRIAL CELLS
    FASEB JOURNAL Volume: 2 Page(s): A1555 - A1555
    03/20/1988 Authors: GALPER JB; SHAMAH SM; GRIENDLING KK; BARNETT JV
  • Secondary signalling mechanisms in angiotensin II-stimulated vascular smooth muscle cells.
    Clin Exp Pharmacol Physiol Volume: 15 Page(s): 105 - 112
    02/01/1988 Authors: Griendling KK; Berk BC; Socorro L; Tsuda T; Delafontaine P; Alexander RW
  • Correlation of receptor sequestration with sustained diacylglycerol accumulation in angiotensin II-stimulated cultured vascular smooth muscle cells.
    J Biol Chem Volume: 262 Page(s): 14555 - 14562
    10/25/1987 Authors: Griendling KK; Delafontaine P; Rittenhouse SE; Gimbrone MA; Alexander RW
  • Potassium depletion selectively inhibits sustained diacylglycerol formation from phosphatidylinositol in angiotensin II-stimulated, cultured vascular smooth muscle cells.
    J Biol Chem Volume: 262 Page(s): 14549 - 14554
    10/25/1987 Authors: Delafontaine P; Griendling KK; Gimbrone MA; Alexander RW
  • REGULATION OF ANGIOTENSIN II-INDUCED DIACYLGLYCEROL FORMATION BY INTRACELLULAR PH IN CULTURED VASCULAR SMOOTH-MUSCLE CELLS
    CIRCULATION Volume: 76 Page(s): 244 - 244
    10/01/1987 Authors: GRIENDLING KK; BERK BC; GIMBRONE MA; ALEXANDER RW
  • Angiotensin II stimulation of vascular smooth muscle phosphoinositide metabolism. State of the art lecture.
    Hypertension Volume: 9 Page(s): III181 - III185
    06/01/1987 Authors: Griendling KK; Berk BC; Ganz P; Gimbrone MA; Alexander RW
  • ALPHA-THROMBIN STIMULATES NA+/H+ EXCHANGE AND CA2+ MOBILIZATION IN VASCULAR SMOOTH-MUSCLE
    CLINICAL RESEARCH Volume: 35 Page(s): A262 - A262
    04/01/1987 Authors: BERK BC; GRIENDLING KK; BROCK TA
  • NOVEL ENDOTHELIUM-DERIVED ACTIVITY INHIBITING HORMONAL RESPONSIVENESS IN VASCULAR SMOOTH-MUSCLE
    CLINICAL RESEARCH Volume: 35 Page(s): A571 - A571
    04/01/1987 Authors: GANZ P; BERK BC; LEOPOLD JA; GIMBRONE MA; DAVIES PF; GRIENDLING KK; ALEXANDER RW
  • ENDOTHELIUM INHIBITS ANGIOTENSIN-II RECEPTOR ACTIVATION IN VASCULAR SMOOTH-MUSCLE
    CIRCULATION Volume: 74 Page(s): 413 - 413
    10/01/1986 Authors: GANZ P; BERK BC; LEOPOLD JA; GIMBRONE MA; GRIENDLING KK; ALEXANDER RW
  • HYPOKALEMIA INHIBITS ANGIOTENSIN II-INDUCED LATE DIACYLGLYCEROL FORMATION IN VASCULAR SMOOTH-MUSCLE
    CIRCULATION Volume: 74 Page(s): 416 - 416
    10/01/1986 Authors: DELAFONTAINE P; GRIENDLING KK; RITTENHOUSE SE; GIMBRONE MA; ALEXANDER RW
  • DIFFERENTIAL-EFFECTS OF NOREPINEPHRINE AND PHORBOL ESTER ON ALPHA-ADRENERGIC RECEPTOR COUPLING AND TRANSLOCATION IN DDT-MF1 CELLS
    HYPERTENSION Volume: 8 Page(s): 836 - 836
    09/01/1986 Authors: COLUCCI WS; WISE GM; SPERTI G; GRIENDLING KK
  • Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.
    J Biol Chem Volume: 261 Page(s): 5901 - 5906
    05/05/1986 Authors: Griendling KK; Rittenhouse SE; Brock TA; Ekstein LS; Gimbrone MA; Alexander RW
  • SUSTAINED DIACYLGLYCEROL STIMULATION BY ANGIOTENSIN-II IN VASCULAR SMOOTH-MUSCLE
    CLINICAL RESEARCH Volume: 34 Page(s): A666 - A666
    04/01/1986 Authors: GRIENDLING KK; RITTENHOUSE SE; BROCK TA; GIMBRONE MA; ALEXANDER RW
  • Pregnancy-induced changes in sheep uterine and carotid arteries.
    Am J Physiol Volume: 248 Page(s): H658 - H665
    05/01/1985 Authors: Griendling KK; Fuller EO; Cox RH
  • ANGIOTENSIN-II-INDUCED FORMATION OF DIACYLGLYCEROL IN CULTURED VASCULAR SMOOTH-MUSCLE
    HYPERTENSION Volume: 7 Page(s): 844 - 844
    01/01/1985 Authors: GRIENDLING KK; BROCK TA; RITTENHOUSE SE; GIMBRONE MA; ALEXANDER RW
  • Regional differences in alpha 1-adrenoceptor numbers and responses in canine aorta.
    Am J Physiol Volume: 247 Page(s): H928 - H935
    12/01/1984 Authors: Griendling KK; Sastre A; Milnor WR
  • Relation between alpha adrenergic receptor occupation and contractile response: radioligand and physiologic studies in canine aorta.
    J Pharmacol Exp Ther Volume: 229 Page(s): 887 - 896
    06/01/1984 Authors: Sastre A; Griendling KK; Rusher MM; Milnor WR
  • BINDING AND PHYSIOLOGIC PROPERTIES OF ALPHA-ADRENERGIC RECEPTORS IN CANINE AORTA
    FEDERATION PROCEEDINGS Volume: 40 Page(s): 451 - 451
    01/01/1981 Authors: SASTRE A; GRIENDLING KK; RUSHER MM; MILNOR WR
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