Kathy Griendling PhD
- Department of Medicine
Professor
- (404) 727-3364
- kgriend@emory.edu
- Griendling Basic Science Cardiology Lab
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Lab Address
HSRBII, 2nd floor
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Emory University
Medicine/Cardiology
254N HSRBII, 1750 Haygood Drive
Overview
Dr. Kathy Griendling received her PhD in Cardiovascular Physiology from Johns Hopkins University. She is currently a Professor of Medicine in the Cardiology Division of Emory University and Executive Associate Dean for Faculty Affairs and Professional Development in the School of Medicine. Her research has been focused on the role of NADPH oxidases (Nox) in vascular biology and disease. She has a particular interest in how reactive oxygen species (ROS) derived from these enzymes regulate the signaling pathways leading to smooth muscle proliferation, migration and differentiation. Using transgenic and knockout mouse models, her laboratory has demonstrated a role for the NADPH oxidases in hypertension, collateral formation, vessel contraction and restenosis. Ongoing research is focused on Poldip2, a p22phox binding protein that regulates Nox4 activity and plays major roles in cell cycle progression, matrix regulation, and endothelial barrier function. Dr. Griendling has trained 46 post-doctoral fellows and PhD students, many of whom have successful academic careers. She is a member of the graduate faculty in Molecular and Systems Pharmacology.
Academic Appointment
- R. Wayne Alexander MD Professor of Medicine, Emory University School of Medicine
- Professor of Medicine, Emory University School of Medicine
Education
Degrees
- PhD from Johns Hopkins University School of Medicine
- BS, Biology from Pennsylvania State University
- BS, Mathematics from Pennsylvania State University
Research
Focus
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Vascular Biology
Dr. Griendlings laboratory was one of the first to identify the role of the NADPH oxidases (Nox enzymes) in vascular physiology and pathophysiology. She and her colleagues identified the functions of Nox1 and Nox4 and explored their individual roles in vascular physiology and pathology. Their work has provided insight into NADPH oxidase activators, their subunit composition, the specific signaling pathways that they modify, their roles in migration, differentiation, growth and cytoskeletal reorganization, and their roles in hypertension and diabetic vascular disease. Most recently, her laboratory discovered, cloned and characterized the first known regulator of Nox4, Poldip2, and current work is focused on the physiology and pathophysiology of this novel and complex protein.
Publications
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Polymerase delta-interacting protein 2 mediates brain vascular permeability by regulating ROS-mediated ZO-1 phosphorylation and localization at the interendothelial border.
Cell Commun Signal Volume: 23 Page(s): 9
01/07/2025 Authors: Wang K; Qu H; Hu R; Lassgue B; Eaton DC; Song C; Mu J; Griendling KK; Hernandes MS -
RNA Sequencing Atherosclerosis Data Sets: Expanding Potential Therapeutic Targets.
Circ Res Volume: 134 Page(s): 1424 - 1426
05/24/2024 Authors: Hernandes MS; Griendling KK -
Novel role of vascular chemerin in blood vessel tone.
Am J Physiol Heart Circ Physiol Volume: 325 Page(s): H321 - H322
08/01/2023 Authors: Hu R; Bulger DA; Griendling KK -
Novel Mechanism by Which Extracellular Cyclic GMP Induces Natriuresis.
Circ Res Volume: 132 Page(s): 1141 - 1143
04/28/2023 Authors: Bulger DA; Griendling KK -
Doris Duke Charitable Foundation Fund to Retain Clinical Scientists: innovating support for early-career family caregivers.
J Clin Invest Volume: 132
12/01/2022 Authors: Jagsi R; Beeland TD; Sia K; Szczygiel LA; Allen MR; Arora VM; Bair-Merritt M; Bauman MD; Bogner HR; Daumit G -
Role of NADPH Oxidases in Blood-Brain Barrier Disruption and Ischemic Stroke.
Antioxidants (Basel) Volume: 11
09/30/2022 Authors: Hernandes MS; Xu Q; Griendling KK -
Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation.
Cardiovasc Res Volume: 118 Page(s): 2506 - 2518
08/24/2022 Authors: Dolmatova EV; Forrester SJ; Wang K; Ou Z; Williams HC; Joseph G; Kumar S; Valdivia A; Kowalczyk AP; Qu H -
Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome.
J Am Heart Assoc Volume: 11 Page(s): e025181
05/17/2022 Authors: Ou Z; Dolmatova E; Mandavilli R; Qu H; Gafford G; White T; Valdivia A; Lassgue B; Hernandes MS; Griendling KK -
NADPH Oxidase 1 Mediates Acute Blood Pressure Response to Angiotensin II by Contributing to Calcium Influx in Vascular Smooth Muscle Cells.
Arterioscler Thromb Vasc Biol Volume: 42 Page(s): e117 - e130
05/01/2022 Authors: Park J-M; Do VQ; Seo Y-S; Kim HJ; Nam JH; Yin MZ; Kim HJ; Kim SJ; Griendling KK; Lee M-Y -
Oxidative Stress and Hypertension.
Circ Res Volume: 128 Page(s): 993 - 1020
04/02/2021 Authors: Griendling KK; Camargo LL; Rios FJ; Alves-Lopes R; Montezano AC; Touyz RM