Joe Sabatino

Current Status: Alumni

Graduate Department: Immunology and Molecular Pathogenesis

Other Degrees: BA in Neuroscience, Colgate University;  

Advisor(s): Brian Evavold, PhD;

Hometown: New Orleans, LA

Hobbies

Traveling, Eating, Beer brewing

Research

Using a highly sensitive measure of receptor-ligand affinity developed by colleagues at the Georgia Institute of Technology, I compared the affinities of CD4+ T cell responses in experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, with an acute infection by lymphocytic choriomeningitis virus (LCMV).  My PhD research demonstrated for the first time the existence of low affinity CD4+ T cells in both EAE and LCMV that were previously undetectable by traditional measures of T cell affinity.  These studies revealed that CD4+ T cell responses toward both myelin and viral antigens comprise a wide range of low to high affinity T cells, all of which contribute substantially to immunity.  These findings may have significant implications for the development of more effective therapies for both autoimmunity and infection.

Graduation Year: 2012

Residency: Neurology, Johns Hopkins University

Mentor Web Site(s):