Selected Publications
For a full list of publications, visit the Miller Lab website or Dr. Miller’s Google Scholar profile.
Kim D, Bhargava R, Wang SC, Lee D, Patel R, Oh S, Bowman RW, Na CH, O'Sullivan RJ, Miller KM. TRIM24 directs replicative stress responses to maintain ALT telomeres via chromatin signaling. bioRxiv [Preprint]. 2024 Oct 18:2024.10.18.618947. PMID: 39463989; PMCID: PMC11507842
Liu, J., Perren, J.O., Rogers, C.M., Wen, A.X., Nimer, S., Halliday, J., Fitzgerald, D.M., Mei, Q., Nehring, R., Crum, M., Kozmin, S.G., Xia, J., Cooke, M.B., Zhai, Y., Bates, D., Lei, L., Hastings, P.J., Artsimovitch, I., Herman, C., Sung, P.M., Miller, K.M.# and Rosenberg, S.M.# (2024). Endogenous DNA damage at sites of terminated transcripts. Nature (In press).
Xhemalce, B.#, Miller K.M.# & Gromak, N#. (2024). Epitranscriptome in action: RNA modifications in the DNA damage response. Molecular Cell. Oct 3;84(19):3610-3626.
McCann, J.L.*, Cristini, A.*, Law, E.K., Lee, S.Y., Tellier, M., Carpenter, M.A., Beghè, C., Kim, J.J., Sanchez, A., Jarvis, D.J., Stefanovska, B., Temiz, N.A., Bergstrom, E.N., Salamango, M.C., Brown, M.R., Murphy, S., Alexandrov, L.B., Miller, K.M. #, Gromak, N.#, Harris, R.S#. (2023). APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer. Nature Genetics. 55:1721-1734
Lee, D., Apelt, K., Lee, S., Luijsterburg, M.S., Leung, J.W.C.#, Miller, K.M.# (2022). ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination. Nucleic Acids Research. Mar 7:gkac160.
Kumbhar, R., Sanchez, A. Perren, J., Gong, F., Corujo, D., Medina, F., Devanathan S.K., Xhemalce, B., Matouschek, A., Buschbeck, M., Buck-Koehntop, B., Miller, K.M. (2021). Poly(ADP-ribose)-binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions. Journal of Cell Biology. 220(7): e202006149.
Kim, J.J.*, Lee, S.Y.*, Choi, J., Woo H.G., Xhemalce, B., Miller, K.M. (2020). PCAF-mediated histone acetylation promotes replication fork degradation by MRE11 and EXO1 in BRCA-deficient cells. Molecular Cell. 80(2):327-344
Highlighted in: Leuzzi G, Taglialatela A and Ciccia A. HATtracting Nucleases to Stalled Forks. Molecular Cell 80, Oct 15.
Kim, J.J.*, Lee, S.Y.*, Gong, F., Battenhouse, A.M., Boutz, D.R., Bashyal, A., Refvik, S.T., Chiang, C.M., Xhemalce, B., Paull, T.T., Brodbelt, J.S., Marcotte, E.M., Miller, K.M. (2019). Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Genes & Development. 33(23-24):1751-74.
Xia, J.*, Chiu, L-Y.*, Nehring, R.B., Bravo Núñez, M.A., Mei, Q., Perez, M., Zhai, Y., Fitzgerald, D.M., Pribis, J.P., Wang, Y., Wang, Y., Hu, C.W., Powell, R.T., LaBonte, S.A., Jalali, A., Matadamas Guzmán, M.L., Lentzsch, A.M., Szafran, A.T., Joshi, M.C., Richters, M., Gibson, J.L., Frisch, R.L., Hastings, P.J., Bates, D., Queitsch, C., Hilsenbeck, S., Coarfa, C., Hu, J.C., Siegele, D.A., Scott, K.L., Liang, H., Mancini, M.A., Herman, C.#, Miller, K.M.#, Rosenberg, S.M.# (2019) Bacteria-to-human protein networks reveal origins of endogenous DNA damage, Cell. Jan 10;176(1-2):127-143.
Research Highlight: Burgess, D.J. (2019) Human protein mutagens found via bacteria, Nature Reviews Genetics.
Gong, F., Clouaire, T., Aguirrebengoa, M., Legube, G., Miller, K.M. (2017). Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair, Journal of Cell Biology. 216(7):1959-1974.
Spotlight: Price, B. (2017) KDM5A demethylase: Erasing histone modifications to promote repair of DNA breaks, Journal of Cell Biology.
Leung, J.W.C., Makharashvili, N., Agarwal, P., Pourpre, R., Cammarata, M.B., Cannon, J.R., Sherker, A., Durocher, D., Brodbelt, J.S., Paull, T.T., & Miller, K.M. (2017). ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair, Genes & Development. 31(3):260-274
Chen, W., Ebelt, N.D., Stracker, T.H., Xhemalce, B., Van Den Berg, C.L., Miller, K.M. (2015). ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion, eLife. Jun 1;4.
Gong, F.*, Chiu, L.*, Cox, B., Aymard, F., Clouaire, T., Leung, J.W.C., Cammarata, M., Perez, M., Agarwal, P., Brodbelt, J.S., Legube, G. and Miller, K.M. (2015). Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination, Genes & Development. 29:197-211.
Rodriguez, R.*, Miller, K.M.*, Forment, J.V., Bradshaw, C.R., Nikan, M., Britton, S., Oelschlaegel, T., Xhemalce, B., Balasubramanian, S.#, Jackson, S.P.# (2012). Small molecule-induced DNA damage identifies druggable alternative DNA structures in human genes, Nature Chemical Biology. 8, 301–310. (Nature Chemical Biology comment Mergny JL, Feb 2012.
Miller, K.M., Tjeertes, J.V., Coates, J., Legube, G., Polo, S.E., Britton, S., Jackson, S.P. (2010). Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA non-homologous end-joining, Nature Structural & Molecular Biology. 17:1144.
Miller, K.M.*, Rog, O.*, Cooper, J.P. (2006). Semi-conservative DNA replication through telomeres requires Taz1, Nature. 440 (7085):824-8. (News and Views, Nature Structural & Molecular Biology by Karlseder J, May 2006, PMID: 16738605.)
Note: (#Co-corresponding author, *Equal contribution)