Research

The research team in the Buchwald Laboratory study ways to use radiation to enhance the anti-tumor immune response.

The Deng Laboratory is developing novel anticancer therapies through modulation of apoptotic cell death, DNA replication stress, DNA damage/repair, senescence and immune response.

The goal of the Dynan Laboratory is to obtain a better understanding of the biological effects of ionizing radiation and to apply this knowledge to help prevent and cure cancer.

Research work in the Kesarwala Laboratory interfaces with radiation oncology and biology, cancer cell metabolism, and molecular imaging.

The focus of Dr. Khan's lab is to understand the radiation abscopal effect and translate these findings into clinical trials.

The central goal of the Orthwein Lab is to understand the mechanisms by which B-cells diversify their genome to elicit a protective immune response against pathogens.

The Spangle Laboratory is focused on understanding how signaling pathways rewire the epigenome in order to develop durable combination therapies for the treatment of cancers characterized by aberrant PI3K activation.

The Sudmeier Lab studies the interplay between the unique microenvironment of the brain and immune cells infiltrating tumors in the brain and the impact of treatments on immune cell biology.

The Yu Laboratory aims to understand how cells respond to DNA replication stress and why this process is deregulated in cancer cells in order to translate this knowledge to improvements in cancer diagnosis and treatment.

The Deep Biomedical Imaging Laboratory develops novel AI-aided analytical and computational tools to enhance the role of quantitative imaging in cancer treatment and to improve the accuracy and precision of radiation therapy.

An ongoing research effort to provide the medical imaging community with a comprehensive repository of reference standard data sets for objective and rigorous evaluation of deformable image registration (DIR) spatial accuracy performance.