The Traynelis Lab published a paper in Neuron entitled, "Context-Dependent GluN2B-Selective Inhibitors of NMDA Receptor Function Are Neuroprotective with Minimal Side Effects." Yuan et al. describe a unique structure-activity relationship and the molecular mechanism governing pH sensitivity of GluN2B-selective NMDAR antagonists, which is clinically significant for neuroprotection during neuronal injury. They identify the dicarboxylate dimer as a new pH-sensitive motif within proteins.
