2024
Chen S, Fan J, Xie P, Ahn J, Fernandez M, Billingham LK, Miska J, Wu JD, Wainwright DA, Fang D, Sosman JA, Wan Y, Zhang Y, Chandel NS, Zhang B. (2024) CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4. J Clin Invest. 2024 Mar 5;134(8):e170071. doi: 10.1172/JCI170071. PMID: 38441967; PMCID: PMC11014673.
Zhu Y, Banerjee A, Xie P, Ivanov AA, Uddin A, Jiao Q, Chi JJ, Zeng L, Lee JY, Xue Y, Lu X, Cristofanilli M, Gradishar WJ, Henry CJ, Gillespie TW, Bhave MA, Kalinsky K, Fu H, Bahar I, Zhang B, Wan Y. (2024) Pharmacological suppression of the OTUD4-CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers. J Clin Invest. 2024 Mar 26:e176390. doi: 10.1172/JCI176390. Epub ahead of print. PMID: 38530357.
Zeng L, Zhu Y, Cui X, Chi J, Uddin A, Zhou Z, Song X, Dai M, Cristofanilli M, Kalinsky K, Wan Y. (2024) Tuning Immune-Cold Tumor by Suppressing USP10/B7-H4 Proteolytic Axis Reinvigorates Therapeutic Efficacy of ADCs. Adv Sci. 2024 Aug https://doi.org/10.1002/advs.202400757.
2023
Fu Z, Chen S, Zhu Y, Zhang D, Xie P, Jiao Q, Chi J, Xu S, Xue Y, Lu X, Song X, Cristofanilli M, Gradishar WJ, Kalinsky K, Yin Y, Zhang B, Wan Y (2023). Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity. Science Advances. Jan 6;9(1). PMID: 36608132
Zeng L, Zhu Y, Moreno CS, Wan Y (2023). New insights into KLFs and SOXs in cancer pathogenesis, stemness, and therapy. Seminars in Cancer Biology. May; 90:29-44. PMID: 35245349
2022
Hophan SL, Odnokoz O, Liu H, Luo Y, Khan S, Gradishar W, Zhou Z, Badve S, Torres MA, Wan Y (2022). Ductal carcinoma in situ of breast: from molecular etiology to therapeutic management. Endocrinology. Apr 1;163(4). PMID: 35245349
Wavelet-Vermuse C, Odnokoz O, Xue Y, Lu X, Cristofanilli M, Wan Y (2022). CDC20-mediated hnRNPU ubiquitination regulates chromatin condensation and anti-cancer drug response. Cancers. Jul 31;14(15):3732. PMID: 35954396
2021
Zhu X, Zhang Y, Luo Q, Wu X, Huang F, Shu T, Wan Y, Chen H, Liu Z (2021). The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP. Signal Transduct Target Ther. Jul 14;6(1):264. PMID: 34257276
Odnokoz O, Wavelet-Vermuse C, Hophan SL, Bulun S, Wan Y (2021).ARID1 proteins: from transcriptional and post-translational regulation to carcinogenesis and potential therapeutics. Epigenomics. May;13(10):809-823. PMID: 33890484
Park SH, Fong KW, Kim J, Wang F, Lu X, Lee Y, Brea LT, Wadosky K, Guo C, Abdulkadir SA, Crispino JD, Fang D, Ntziachristos P, Liu X, Li X, Wan Y, Goodrich DW, Zhao JC, Yu J (2021). Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer. Sci Adv. Apr 7;7(15) PMID: 33827814
2020
Roh M, Wainwright DA, Wu JD, Wan Y, Zhang B (2020). Targeting CD73 to augment cancer immunotherapy. Curr Opin Pharmacol. Aug;53:66-76. PMID: 32777746
Song X, Zhou Z, Li H, Xue Y, Lu X, Bahar I, Kepp O, Hung M-C, Kroemer G and Wan Y. (2020) Pharmacological suppression of B7-H4 glycosylation restores antitumor immunity in immune-cold breast cancers. Cancer Discovery. Sep 16; CD-20-0402. PMID: 32938586
Zhou Z, Huang F, Shrivastava I, Zhu R, Luo A, Hottiger M, Ivet B, Liu Z, Wan Y. (2020) New insight into the significance of KLF4 PARylation in genome stability, carcinogenesis and cancer therapy. EMBO Molecular Medicine (In Press)
Zhou Z., Zou H., Panzoni L., Lou A., Zhu R., Guan K-L., Bahar I., Liu Z. and Wan Y. (2020) EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability. Cancer Research. Apr 8, canres. 3718.2019. doi: 10.1158/0008-5472.CAN-19-3718. PMID: 32269044
Cullin 4 family of E3 ligases and Tumorigenesis: Genetic Association and Molecular Mechanisms. Zhou Z, Song X, Wavelength C.M, and Wan Y. Book chapter: Cullin-RING Ligases and Protein Neddylation. Springer Nature publisher. Adv Exp Med Biol. 2020;1217:241-259. doi: 10.1007/978-981-15-1025-0_15
Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance. Zhou Z, Song X, Chi JJ, Gius DR, Huang Y, Cristofanilli M, Wan Y. Cell Signal. 2020 Jun;70:109574. doi: 10.1016/j.cellsig.2020.109574. Epub 2020 Feb 19. PMID: 32084531
Targeting CD73 to augment cancer immunotherapy. Roh M, Wainwright DA, Wu JD, Wan Y, Zhang B.Curr Opin Pharmacol. 2020 Aug 7;53:66-76. doi: 10.1016/j.coph.2020.07.001. Online ahead of print. PMID: 32777746
2017-2019
A novel strategy to block mitotic progression for targeted therapy. Chi J.J , Li H, Zhou Z, Ferrer J.I, Xue Y, Wavelet C.M, Shiltz G. E, Zhang Z, Cristofanilli M, Lu X, Bahar I, and Wan Y. EBioMedicine. 2019. Nov; 49:40-54 PMID: 31669221
A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy. Zhou Z, Feng Z, Hu D, Yang P, Gur M, Bahar I, Cristofanilli M, Gradishar WJ, Xie XQ, Wan Y. EBioMedicine. 2019 Jun; 44:98-111. Epub 2019 May 14. PMID: 31101597
ATXN3 promotes breast cancer metastasis by deubiquitinating KLF4. Zou H, Chen H, Zhou Z, Wan Y, Liu Z. 2019. Cancer Lett. Dec 28; 467:19-28. PMID 31563563
CD73, an emerging checkpoint for cancer immunotherapy. Chen S, Wainwright DA, Wu JD, Wan Y, Matei DE, Zhang Y, Zhang B. Immunotherapy. 2019 Jan; 11(11): 983-997. PMID: 31223045
Epithelial mutation in endometriosis: Link to ovarian cancer. Bulun SE, Wan Y, Matei D. Endocrinology. 2019 Feb; 160(3): 626-638. PMID: 30657901
Cao C, Wu H, Vasilatos SN, Chandran U, Qin Y, Wan Y, Oesterreich S, Davidson NE, Huang Y. HDAC5-LSD1 axis regulates antineoplastic effect of natural HDAC inhibitor sulforaphane in human breast cancer cells. 2018. Int J Cancer. Sep 15;143(6):1388-1401. PMID: 29633255
Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges. Kibria G, Ramos EK, Wan Y, Gius DR, Liu H. 2018. Mol Pharm. Sep 4;15(9):3625-3633 PMID: 29771531
Gao Y, Li C, Wei L, Teng Y, Nakajima S, Chen X, Xu J, Legar B, Spagnol ST, Wan Y, Dahl KN, Levine AS, Lan L. 2017. SSRP1 cooperates with PARP and XRCC1 to facilitate single-strand DNA breast repair by chromatin priming. Cancer Res. 2017 May 15;77(10):2674-2685. PMID: 28416484
Zhou Z, Shrivastava I, Lou A, He M, Huang Y, Liu Z, Bahar I and Wan Y. 2017. Novel insight into USP11-XIAP axis in malignant tumor transformation. EBioMedicine. Feb;15:48-61. PMID:28040451
He M., Zhou Z., Tao J., Wu G., and Wan Y. 2017. Ubiquitinase protein ligase and deubiquitinase in tumor metastasis and therapeutics. Pharmacology & Therapeutics Mar 6. pii: S0163-7258(17)30081-5. PMID: 28279784
Zhihua Liu, Honghong Zhou, Yong-Shuo Liu, Rui Zhu, Fang Ding, Yong Wan, and Yi Li. 2017. FBXO32 suppresses breast cancer tumorigenesis through targeting KLF4 to proteasomal degradation. Oncogene Jan 9. doi: 10.1038/onc.2016.479. PMID: 28068319
2012-2016
He M, Zhou Z, Shah AA, Tao J, Zou H, Chen Q, and Wan Y. 2016. The Emerging Role of Deubiquitinating enzymes in genomic integrity, diseases, and therapeutics. Cell and Bioscience. Dec 20;6:62. PMID:28031783
Lu S, Cai C, Yan G, Zhou Z, Wan Y, Cooper GF, Obeid LM, Hannun YA, Lee AV, Lu X. 2016. Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations. Cancer Res. Oct 10. [Epub ahead of print] PMID: 27758891
Zhou Z, He M, Shah AA, and Wan Y. 2016. Insight into APC/C: from cellular function to diseases and therapeutics. Cell Div. Jul 13; 11:9 PMID: 27418942
He M, Zhou Z, Shah AA, Hong Y, Chen Q and Wan Y. 2016. New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics. Cell Div. Mar 31;11:4. PMID: 27042197
Hu D, Gur M, Zhou Z, Gamper A, Hung MC, Fujita N, Lan L, Bahar I and Wan Y. 2015 Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun. Sep 30;6:8419. PMID: 26420673
He H, Li S, Hong Y, Zou H, Chen H, Ding F, Wan Y, Liu Z. 2015. Krüppel-like Factor 4 Promotes Esophageal Squamous Cell Carcinoma Differentiation by Up-regulating Keratin 13 Expression. J Biol Chem. May 22;290(21):13567-77. PMID: 25851906
Zhou Z., Chao J., Zhang L., Takeo F., Kim H., Huang Y., Liu Z. and Wan Y. 2013 Regulation of Rad17 turnover unveils an impact of Rad17-APC cascade in breast carcinogenesis and treatment. J Biol Chem 288(25):18134-45. PMID:23637229
Vasilatos S.N., Katz T.A., Oesterreich S, Wan Y, Davidson N.E. and Huang Y. 2013. Crosstalk between LSD1 and HDACs Mediates Anti-tumor Efficacy of HDAC Inhibitors in Human Breast Cancer Cells. Carcinogenesis (Epub in ahead of print) PMID: 23354309
Gamper A., Kim J., Qiao X. Rathmell K. and Wan Y. 2012. Proteolytic regulation of Krüppel-like Factor 4 (KLF4) by VHL E3 ligase in breast carcinogenesis. Mol Cell. (Epub in ahead of print) PMID: 22284679
Hu D., Zhou Z., Davidson N.E., Huang Y. and Wan Y. 2012. Novel insight into KLF4 proteolytic regulation in estrogen signaling and breast carcinogenesis. J Biol Chem. Mar 2 (Epub in ahead of print) PMID:22389506
2005-2011
Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, Hu D, Wan Y, Seng V, Sheppard-Tillman H, Martin P, Kelly K. 2011 Critical and reciprocal regulation of KLF4 and SLUG in TGF-β-initiated prostate cancer EMT Mol Cell Biol. Dec 27. Epub ahead of print. PMID: 22203039
Hu D., Qiao X., Wu, G., Kim H and Wan Y. 2011. The role of anaphase-promoting complex in developmental control. Seminars in Cell & Develop Biol. (Epub ahead of print) PMID: 21497201
Liu W., Zong W., Wu G., Liu X., and Wan Y. (2011). Turnover of BRCA1 Involves in Radiation-Induced Apoptosis. PLoS ONE Dec 31;5(12):e14484 PMID: 21217819
Zhang L., Fujita T., Wu G., Xiao X. and Wan Y. (2011). Phosphorylation of Anaphase-Promoting Complex Is Involved in TGF-b Signaling Pathway. J Biol Chem. Jan 5. (Epub ahead of print) PMID: 21209074
Hu D., Liu W., Wu. G and Wan Y. (2011). Nuclear translocation of Skp2 facilitates its destruction in response to TGF-b signaling. Cell Cycle Jan 15;10(2). (Epub ahead of print) PMID: 21212736
Hu D. and Wan Y. (2011). Regulation of Krüppel-like Factor 4 (KLF4) by APC pathway in TGF-beta signaling. J Biol Chem Dec 22. (Epub ahead of print) PMID: 21177849
Zhang L., Park C-H, Wu J., Kim H., Liu W., Fujita T., Balasubramani M., Schreiber E.M., Wang X-F and Wan Y. (2010) Proteolysis of Rad17 by Cdh1/APC involves in checkpoint termination and recovery from genotoxic stress. EMBO J. 29(10): 1726-37. PMID: 20424596
Qiao X., Zhang L. Gamper A. Fujita T. and Wan Y. (2010) Cdh1/APC: from cell cycle, genomic integrity to carcinogenesis. Cell Cycle Oct 1;9(19):3904-12. (Epub in ahead of print). PMID: 20935501
Fujita T., Liu W., Doihara H. and Wan Y. (2009) In vivo dissection of Cdh1/APC in breast carcinogenesis. Int J Cancer. 125(4): 826-36. PMID: 19350629
Fujita T., Epperly M.W., Zou H., Gollin S.M., Greenberger J.S., and Wan Y. (2008) Regulation of the anaphase promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells. Mol Biol Cell. 19: 5446-5455 PMID:18843049
Fujita T. Doihara H., Liu W. and Wan Y. (2008) Dissection of the APCCdh1-Skp2 cascade in breast cancer. Clin Cancer Res 14 (7): 1966-1975 PMID:18381934
Liu W., Fujita T., Li W., Yang Q., and Wan Y.( 2008) Proteolysis of CDH1 enhances susceptibility to UV radiation induced apoptosis. Carcinogenesis 29 (2): 263-72. PMID:18174259
Fujita T. Liu W., Hiroyoshi D. and Wan Y.. (2008) Regulation of Skp2-p27 axis by the Cdh1/anaphase promoting complex pathway in colorectal tumorigenesis. Am J. Pathol. Vol 173, No. 1, 217-28. PMID:18535175
Liu W., Wu G., Lobur D., Li W., and Wan Y. (2007) Cdh1-APC targets Skp2 for destruction in TGF-beta-induced growth inhibition. Mol Cell Biol. Vol.27 (8):2967-79 PMID: 17283060
Wu G., Glickstein S., Liu W, Fujita T., Li W., Yang Q., Duvoisin R., and Wan Y. (2007) The APC coordinates the initiation of lens differentiation. Mol Biol Cell. Vol 18 (3):1018-29. PMID:17215516
Li W., Wu G., and Wan Y. (2007) The dual effects of Cdh1 in myogenesis. FASEB J. 21(13): 3606-17.PMID:17601983
1999-2004
Wei W*, Ayad NG*, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr. 2004. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature 428:194-8. PMID:15014503
Macdonald M., Wan Y., Wang W., Roberts B., Cheung T., Erickson R., Kirschner M. W. and Liu X. 2004. Cdc34 is required for cell cycle dependent degradation of c-Ski proto-oncoprotein. Oncogene 23(33): 5643-53 PMID:15122324
Knuesel MP, Wan Y, Xia Z, Holinger EP, Lowe N, Wang W, Liu X. 2003. Identification of novel protein-protein interactions using a versatile mammalian TAP expression system. Mol Cell Proteomics (11): 1225-33 PMID:12963786
Wan Y., Liu X. and Kirschner W. M. 2001. The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Molecular Cell 8(5): 1027-1039. PMID:11741538
Wan Y. and Kirschner W. M. 2001. Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities. Proc. Natl. Acad. Sci. USA 98: 13066-13071. PMID:11687641
1995-1998
Jiang Y., Ma W., Wan Y., Kozasa T., Hassatli T., and Huang X-Y. 1998. Ga12 directly stimulates a tyrosine kinase and a Ras-Gap through conserved PH-BM domain. Nature 395: 808-813. PMID:9796816
Wan Y. and Huang X-Y. 1998. Analysis of the Gs/mitogen-activated protein kinase pathway in mutant S49 cells. J. Biol. Chem. 273: 14533-14537. PMID:9603967
Wan Y., Bence K., Hata A., Kurosaki T. Veillette A., and Huang X-Y. 1997. Genetic evidence for a tyrosine kinase cascade preceding the mitogen-activated protein kinase cascade in vertebrate G-protein signaling. J. Biol. Chem. 272: 17209-17215. PMID:9202044
Wan Y., Kurosaki T., and Huang X-Y. 1996. Tyrosine kinases in activation of the MAP kinase cascade by G-protein-couple receptors. Nature 380: 541-544. PMID:8606776
Langhans-Rajasekaran S., Wan Y., and Huang X-Y. 1995. Activation of Tsk and Btk tyrosine kinases by G protein beta-gamma subunits. Proc. Natl. Acad. Sci. USA . 92: 8601-8605. PMIOD:7567982