Patgiri Lab

The Patgiri lab studies how mutations in mitochondrial and other metabolic genes cause devastating neuromuscular disorders to guide potential therapy. Mitochondrial diseases currently have no FDA-approved therapy. Therefore, we are using small molecule and enzyme engineering approaches to reestablish mitochondrial and metabolic homeostasis in cell and animal models of mitochondrial disease. Currently, we are testing the therapeutic potential of (a) correcting biochemical consequences (e.g., redox, bioenergetic) of mutated metabolic genes and (b) selectively eliminating toxic, defective mitochondria in disease. In another project, we are developing strategies to modulate metabolism in the tumor-immune microenvironment to boost the cytotoxicity of immune cells (T cells and macrophages) as anticancer therapeutics. For more information, please visit the The Patgiri Lab website.