(a partial list of publications)
p38 MAPK-mediated loss of nuclear RNase III enzyme Drosha underlies amyloid beta-induced neuronal stress in Alzheimer's disease.
Xu H, Liu X, Li W, Xi Y, Su P, Meng B, Shao X, Tang B, Yang Q, Mao Z. Aging Cell. 2021 Oct;20(10):e13434. doi: 10.1111/acel.13434. Epub 2021 Sep 16. PMID: 34528746
Chaperone-mediated autophagy controls the turnover of E3 ubiquitin ligase MARCHF5 and regulates mitochondrial dynamics.
Nie T, Tao K, Zhu L, Huang L, Hu S, Yang R, Xu P, Mao Z, Yang Q. Autophagy. 2021 Oct;17(10):2923-2938. doi: 10.1080/15548627.2020.1848128. Epub 2020 Dec 1. PMID: 33970775
Chaperone-mediated autophagy: Advances from bench to bedside.
Li W, Nie T, Xu H, Yang J, Yang Q, Mao Z. Neurobiol Dis. 2019 Feb;122:41-48. doi: 10.1016/j.nbd.2018.05.010. Epub 2018 May 22. PMID: 29800676 Review.
p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1.
He Y, She H, Zhang T, Xu H, Cheng L, Yepes M, Zhao Y, Mao Z. J Cell Biol. 2018 Jan 2;217(1):315-328. doi: 10.1083/jcb.201701049. Epub 2017 Dec 1. PMID: 29196462
Phosphorylation of LAMP2A by p38 MAPK couples ER stress to chaperone-mediated autophagy.
Li W, Zhu J, Dou J, She H, Tao K, Xu H, Yang Q, Mao Z. Nat Commun. 2017 Nov 24;8(1):1763. doi: 10.1038/s41467-017-01609-x. PMID: 29176575
Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
Koo J, Wu X, Mao Z, Khuri FR, Sun SY. J Biol Chem. 2015 May 29;290(22):14120-9. doi: 10.1074/jbc.M114.633057. Epub 2015 Apr 20. PMID: 25897075
Stress induces p38 MAPK-mediated phosphorylation and inhibition of Drosha-dependent cell survival.
Yang Q, Li W, She H, Dou J, Duong DM, Du Y, Yang SH, Seyfried NT, Fu H, Gao G, Mao Z. Mol Cell. 2015 Feb 19;57(4):721-734. doi: 10.1016/j.molcel.2015.01.004. PMID: 25699712
De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome.
Yuan Y, Zhang J, Chang Q, Zeng J, Xin F, Wang J, Zhu Q, Wu J, Lu J, Guo W, Yan X, Jiang H, Zhou B, Li Q, Gao X, Yuan H, Yang S, Han D, Mao Z, Chen P, Lin X, Dai P. Cell Res. 2014 Nov;24(11):1370-3. doi: 10.1038/cr.2014.77. Epub 2014 Jun 10. PMID: 24913193
Oxidation of survival factor MEF2D in neuronal death and Parkinson's disease.
Gao L, She H, Li W, Zeng J, Zhu J, Jones DP, Mao Z, Gao G, Yang Q. Antioxid Redox Signal. 2014 Jun 20;20(18):2936-48. doi: 10.1089/ars.2013.5399. Epub 2014 Feb 3. PMID: 24219011
Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients.
She H, Yang Q, Shepherd K, Smith Y, Miller G, Testa C, Mao Z. J Clin Invest. 2011 Mar;121(3):930-40. doi: 10.1172/JCI43871. PMID: 21393861
Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.
Rashidian J, Rousseaux MW, Venderova K, Qu D, Callaghan SM, Phillips M, Bland RJ, During MJ, Mao Z, Slack RS, Park DS. J Neurosci. 2009 Oct 7;29(40):12497-505. doi: 10.1523/JNEUROSCI.3892-09.2009. PMID: 19812325
Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death.
Tian B, Yang Q, Mao Z. Nat Cell Biol. 2009 Feb;11(2):211-8. doi: 10.1038/ncb1829. Epub 2009 Jan 18. PMID: 19151707
Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy.
Yang Q, She H, Gearing M, Colla E, Lee M, Shacka JJ, Mao Z. Science. 2009 Jan 2;323(5910):124-7. doi: 10.1126/science.1166088. PMID: 19119233
Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion.
Liu R, Tian B, Gearing M, Hunter S, Ye K, Mao Z. Proc Natl Acad Sci U S A. 2008 May 27;105(21):7570-5. doi: 10.1073/pnas.0712306105. Epub 2008 May 16. PMID: 18487454
Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity.
Wang Y, White MG, Akay C, Chodroff RA, Robinson J, Lindl KA, Dichter MA, Qian Y, Mao Z, Kolson DL, Jordan-Sciutto KL. J Neurochem. 2007 Oct;103(2):439-55. doi: 10.1111/j.1471-4159.2007.04746.x. PMID: 17897354
Tissue-type plasminogen activator and the low-density lipoprotein receptor-related protein mediate cerebral ischemia-induced nuclear factor-kappaB pathway activation.
Zhang X, Polavarapu R, She H, Mao Z, Yepes M. Am J Pathol. 2007 Oct;171(4):1281-90. doi: 10.2353/ajpath.2007.070472. Epub 2007 Aug 23. PMID: 17717150
Engineering metal ion coordination to regulate amyloid fibril assembly and toxicity.
Dong J, Canfield JM, Mehta AK, Shokes JE, Tian B, Childers WS, Simmons JA, Mao Z, Scott RA, Warncke K, Lynn DG. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13313-8. doi: 10.1073/pnas.0702669104. Epub 2007 Aug 8. PMID: 17686982
Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2.
Tang X, Wang X, Gong X, Tong M, Park D, Xia Z, Mao Z. J Neurosci. 2005 May 11;25(19):4823-34. doi: 10.1523/JNEUROSCI.1331-05.2005. PMID: 15888658
Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival.
Wang X, Tang X, Li M, Marshall J, Mao Z. J Biol Chem. 2005 Apr 29;280(17):16705-13. doi: 10.1074/jbc.M501819200. Epub 2005 Feb 25. PMID: 15735306
Calcium channel and NMDA receptor activities differentially regulate nuclear C/EBPbeta levels to control neuronal survival.
arshall J, Dolan BM, Garcia EP, Sathe S, Tang X, Mao Z, Blair LA. Neuron. 2003 Aug 14;39(4):625-39. doi: 10.1016/s0896-6273(03)00496-3. PMID: 12925277
ERK5 activation of MEF2-mediated gene expression plays a critical role in BDNF-promoted survival of developing but not mature cortical neurons.
Liu L, Cavanaugh JE, Wang Y, Sakagami H, Mao Z, Xia Z. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8532-7. doi: 10.1073/pnas.1332804100. Epub 2003 Jun 25. PMID: 12826611
Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.
Gong X, Tang X, Wiedmann M, Wang X, Peng J, Zheng D, Blair LA, Marshall J, Mao Z. Neuron. 2003 Apr 10;38(1):33-46. doi: 10.1016/s0896-6273(03)00191-0. PMID: 12691662