Emory University School of Medicine
Emory University School of Medicine
Department of Pharmacology and Chemical Biology
Department of Pharmacology and Chemical Biology

Publications

The Chang Lab is part of the Department of Pharmacology and Chemical Biology

Journal Articles:

  1. Jae Won Chang, Mohammed Bhuiyan, Hsiu-Ming Tsai, Hannah J. Zhang, Gang Li, Shaghayegh Fathi, David McCuteheon, Lara Leoni, Richard Freifelder, Chin-Tu. Chen, Raymond E. Moellering, “In vivo imaging of the tumor-associated enzyme NCEH1 with a covalent PET probe” Under review.
  2. Myeonggyo Jeong, Hyunkee Lee, Gibeom Kim, Jeyun Jo, Jae Won Chang, Jee H. Jung, Young-Ger Shr, Hwayoung Yun, “Divergent synthetic route to oxidized benzofulvene sesquiterpenoids: Protecting-group-free total synthesis of nicotianasesterpenes A, B and a Polygonum sesquiterpenoid” Eur. J. Org. Chem , 2019 , 39, 6714-6719.
  3. Gang Li, Mark A. Eckert, Jae Won Chang, Jeffrey E. Montgomery, Agnieszka Chryplewicz, Ernst Lengyel, Raymond E. Moellering, “Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation”, Proc. Natl. Acad. Sci. USA. 2019 , 116(43), 21493-21500.
  4. Jun X. Huang, Gihoon Lee, Kate E. Cavanaugh, Jae Won Chang, Margaret L. Gardel, Raymond E. Moellering, “High throughput discovery of functional protein modifications by hotspot thermal profiling”, Nature Methods. 2019, 16, 894-901.
  5. Jae Won Chang, Raymond E. Moellering, “No bones about it: Novel small molecules for bone regeneration”, Cell Chem. Biol. 2019, 26, 911-912.
  6. Mark A. Eckert, Fabian Coscia, Agnieszka Chryplewicz, Jae Won Chang, Kyle M. Hernandez, Shawn Pan, Samantha M. Tienda, Dominik A. Nahotko, Gang Li, Ivana Blazenovic, Ricardo Lastra, Marion Curtis, S. Diane Yamada, Ruth Perets, Stephanie McGregor, Jorge Andrade, Oliver Fiehn, Raymond E. Moellering, Matthias Mann, Ernst Lengyel., “Proteomics reveals NNMT as a master metabolic regulator of cancer associated fibroblasts”, Nature. 2019, 569, 723-728.
  7. Anna Czarna, Jinhua Wang, Diana Zelencova, Yao Liu, Xianming Deng, Hwan Geun Choi, Ting-hu Zhang, Wenjun Zhou, Jae Won Chang, Hanne Kildalsen, Ole-morten Seternes, Nathanael S. Gray, Richard Engh, Ulli Rothweiler., “Novel scaffolds for dual specificity tyrosine-phosphorylation-regulated kinase (DYPK1A) inhibitors”, J. Med. Chem . 2018 , 61, 7560-7572.
  8. Jae Won Chang, Jeffrey E. Montgomery, Gihoon Lee, Raymond E. Moellering., “Chemoproteomic profiling of phosphoaspartate modifications in prokaryotes”, Angew. Chem. Int. Ed. Engl. 2018 , 57, 15712-15716.
  9. Michael J. Bollong, Gihoon Lee, John S. Coukos, Hwayoung Yun, Claudio Zambaldo, Jae Won Chang, Emily N. Chin, Insha Ahmad, Arnab K. Chatterjee, Luke L. Lairson, Peter G. Schultz, Raymond E. Moellering., “A metabolic-derived protein modification integrates glycolysis with KEAP1-NRF2 signaling”, Nature. 2018, 562, 600-604.
  10. Gang Li, Jeffrey E. Montgomery, Mark A. Eckert, Jae Won Chang, Samantha M. Tienda, Ernst Lengyel, Raymond E. Moellering., “An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells”, Nat Commun. 2017, 24; 8(1):1775.
  11. Jae Won Chang, Gihoon Lee, John S. Coukos, Raymond E. Moellering., “Profiling reactive metabolites via chemical trapping and targeted mass spectrometry”, Anal. Chem . 2016 , 88, 6658-6661.
  12. Matthew W. Buczynski, Melissa A. Herman, Ku-Lung Hsu, Luis A. Natividad, Cristina Irimia, Ilham Y. Polis, Holly Pugh, Jae Won Chang, Micah J. Niphakis, Benjamin F. Cravatt, Marisa Roberto, Loren H. Parsons., “Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure”, Proc. Natl. Acad. Sci. USA. 2016, 113, 1086-1091.
  13. Rebecca A. Kohnz, Melinda M. Mulvihill, Jae Won Chang, Ku-Lung Hsu, Antonio Sorrentino, Benjamin F. Cravatt, Sourav Bandyopadhyay, Andrei Goga, Daniel K. Nomura., “Activity-based protein profiling of oncogene-driven changes in metabolism reveals broad dysregulation of PAFAH1B2 and 1B3 in cancer”, ACS Chem. Biol. 2015, 10, 1624-1630.
  14. Jae Won Chang, Andrea M. Zuhl, Anna E. Speers, Sherry Niessen, Steven J. Brown, Melinda M. Mulvihill, Yi Chiao Fan, Timothy P. Spicer, Mark Southern, Louis Scampavia, Virneliz Fernandez-Vega, Melissa M. Dix, Michael D. Cameron, Peter S. Hodder, Hugh Rosen, Daniel K. Nomura, Ohyun Kwon, Ku-Lung Hsu, Benjamin F. Cravatt., “Selective inhibitor of Platelet-Activating Factor Acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival”, ACS Chem. Biol. 2015, 10, 925-932.
  15. Andrea Galmozzi, Si B. Sonne, Svetlana Altshulet-Keylin, Yutaka Hasegawa, Kosaku Shinoda, Ineke H.N. Luijten, Jae Won Chang, Louis Z. Sharp, Benjamin F. Cravatt, Enrique Saez, Shingo Kajimura., “ThermoMouse: An in vivo model to identify modulators of UCP1 expression in brown adipose tissue”, Cell Rep. 2014, 11, 1584-1593.
  16. Joseph D. Manna, James A. Wepy, Ku-Lung Hsu, Jae Won Chang, Benjamin F. Cravatt, Lawrence J. Marnett., “Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells”, J. Biol.Chem . 2014 , 289, 33741-33753.
  17. Eduardo Dominguez, Andrea Galmozzi, Jae Won Chang, Ku-Lung Hsu, Joanna Pawlak, Weiwei Li, Cristina Godio, Jason Thomas, David Partida, Sherry Niessen, Paul E. O'Brien, Aaron P. Russell, Matthew J. Watt, Daniel K. Nomura, Benjamin F. Cravatt, Enrique Saez., “Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes”, Nat. Chem. Biol. 2014 , 10, 113-121.
  18. Ku-Lung Hsu, Katsunori Tsuboi, Jae Won Chang, Anna E. Speers, Holly Pugh, Benjamin F. Cravatt., “Discovery and optimization of piperidyl-1,2,3-Triazole ureas as potent, selective, and in vivo-active inhibitors of a/b-hydrolase domain containing 6 (ABHD6)”, J. Med. Chem . 2013 , 56, 8270-8279.
  19. Stephen P. Holly, Jae Won Chang, Weiwei Li, Sherry Niessen, Ryan Phillips, Raymond Piatt, Justin L. Black, Matthew Smith, Yacine Boulaftali, Andrew Weyrich, Wolfgang Bergmeier, Benjamin F. Cravatt, Leslie V., “Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation”, Cell Chem. Biol. 2013, 20, 1125-1134.
  20. Micah J. Niphakis, Armand B. Cognetta III, Jae Won Chang, Matthew W. Buczynski, Loren H. Parsons, Frederika Byrne, James J. Burston, Vitoria Chapman, Benjamin F. Cravatt., “Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors”, ACS Chem. Neurosci. 2013, 4, 1322-1332.
  21. Jae Won Chang, Armand Cognetta, Micah Niphakis, Benjamin F. Cravatt., “Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition”, ACS Chem. Biol. 2013, 8, 1590-1599.
  22. Tiziana Bisogno, Anu Mahadevan, Roberto Coccurello, Jae Won Chang, Marco Allara, Ygang Chen, Aron Lichtman, Benjamin Cravatt, Anna Moles, Vincenzo Di Marzo., “A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonylglycerol with potential anti-obesity effects”, Br. J. Pharmacol . 2013, 169, 784-793.
  23. Alexander Adibekian, Brent R. Martin, Jae Won Chang, Ku-Lung Hsu, Katsunori Tsuboi, Daniel A. Bachovchin, Anna E. Speers, Steven J. Brown, Timothy Spicer, Virneliz Fernandez-Vega, Jill Ferguson, Peter S. Hodder, Hugh Rosen, Benjamin F. Cravatt., “Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes”, J. Am. Chem. Soc . 2012 , 134, 10345-10348.
  24. Jae Won Chang, Micah J. Niphakis, Kenneth M. Lum, Armand B. Cognetta, III, Chu Wang, Megan L. Matthews, Sherry Niessen, Matthew W. Buczynski, Loren H. Parsons, Benjamin F. Cravatt., “Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates”, Cell Chem. Biol. 2012, 19, 579-588. - Chemistry & Biology Preview. 2012, 19, 545. - Featured in SciBX. 2012, 5, 528.
  25. Mathew J. Garnett, Elena J. Edelman, Sonja J. Heidorn, Chris D. Greenman, Anahita Dastur, King Wai Lau, Patricia Greninger, I. Richard Thompson, Xi Luo, Jorge Soares, Qingsong Liu, Francesco Iorio, Didier Surdez, Li Chen, Randy J. Milano, Graham R. Bignell, Ah T. Tam, Helen Davies, Jesse A. Stevenson, Syd Barthorpe, Stephen R. Lutz, Fiona Kogera, Karl Lawrence, Anne McLaren-Douglas, Xeni Mitropoulos, Tatiana Mironenko, Helen Thi, Laura Richardson, Wenjun Zhou, Frances Jewitt, Tinghu Zhang, Patrick O'Brien, Jessica L. Boisvert, Stacy Price, Wooyoung Hur, Wanjuan Yang, Xianming Deng, Adam Butler, Hwan Geun Choi, Jae Won Chang, Jose Baselga, Ivan Stamenkovic, Jeffrey A. Engelman, Sreenath V. Sharma, Oliver Delattre, Julio Saez-Rodriguez, Nathanael S. Gray, Jeffrey Settleman, P. Andrew Futreal, Daniel A. Haber, Michael R. Stratton, Sridhar Ramaswamy, Ultan McDermott, Cyril H. Benes., “Systematic identification of genomic markers of drug sensitivity in cancer cells”, Nature. 2012, 483, 570-575.
  26. Qingsong Liu, Seong A. Kang, Carson C. Thoreen, Wooyoung Hur, Jinhua Wang, Jae Won Chang, Andrew Markhard, Jianming Zhang, Taebo Sim, David M. Sabatini, Nathanael S. Gray., “Development of ATP-Competitive mTOR Inhibitors”, Methods Mol. Biol. 2012, 821, 447-460.
  27. Jae Won Chang, Raymond E. Moellering, Benjamin F. Cravatt., “An activity-based imaging probe for the integral membrane hydrolase KIAA1363”, Angew. Chem. Int. Ed. Engl. 2012, 51, 966-970. - Selected as a Hot Paper
  28. Daniel K. Nomura, Donald P. Lombardi, Jae Won Chang, Sherry Niessen, Anna M. Ward, Jonathan Z. Long, Heather H. Hoover, Benjamin F. Cravatt., “Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer”, Cell Chem. Biol. 2011, 18, 846-856.
  29. Jae Won Chang, Daniel K. Nomura, Benjamin F. Cravatt., “A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis”, Cell Chem. Biol. 2011, 18, 476-484.- Selected as a Featured Article- Chemistry & Biology Preview. 2011, 18, 407.
  30. Qingsong Liu, Jae Won Chang, Jinhua Wang, Seong A. Kang, Carson C. Thoreen, Andrew Markhard, Wooyoung Hur, Jianming Zhang, Taebo Sim, David M. Sabatini, Nathanael S. Gray., “Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinoline-3-yl)benzo[h][1,6]naphthyridin-2-(1H)-one as a highly potent, selective mTOR inhibitor for the treatment of cancer”, J. Med. Chem . 2010 , 53, 7146-7155.
  31. Jose B. Saenz, William J. Sun, Jae Won Chang, Jinmei Li, Badry Bursulay, Nathanael S. Gray, David B. Haslam., “Golgicide A reveals essential roles for GBF1 in Golgi assembly and function”, Nat. Chem. Biol. 2009, 5, 157-165.
  32. Carson C. Thoreen, Seong A. Kang, Jae Won Chang, Qingsong Liu, Jianming Zhang, Yi Gao, Laurie J. Reichling, Taebo Sim, David M. Sabatini, Nathanael S. Gray., “An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1”, J. Biol.Chem . 2009 , 284, 8023-8032.
  33. Carsten B. Andersen, Yongqin Wan, Jae Won Chang, Blake Riggs, Christian Lee, Yi Liu, Fabio Sessa, Fabrizio Villa, Nicholas Kwiatkowski, Melissa Suzuki, Laxman Nallan, Rebecca Heald, Andrea Musacchio, Nathanael S. Gray., “Discovery of selective aminothiazole Aurora A kinase inhibitors”, ACS Chem. Biol. 2008, 3 ,180-192.
  34. Min Sung Kim, Yong-Woo Kim, Heung Sik Hahm, Jae Won Chang, Won Koo Lee, Hyun-Joon Ha., “Lewis acid-catalyzed stereospecific ring expansion of aziridine-2-carboxylates to imidazolidin-2-ones”, Chem. Commun . 2005 , 24, 3062-3064.
  35. Chan Sun Park, Min Sung Kim, Taebo Sim, Do Kyu Pyun, Jae Won Chang, Cheol Hae Lee, Daeock Choi, Won Koo Lee, Hyun-Joon Ha., “Novel stereoselective synthesis of functionalized oxazolidinones from chiral aziridines”, J.Org.Chem . 2003, 68, 43-49.
  36. Jae Won Chang, Hyun-Joon Ha, Chan Sun Park, Min Sung Kim, Woo Koo Lee., “An efficient synthesis of N-Boc-D-diphenylalanine from a chiral aziridine-2-carboxylate”, Heterocycles. 2002, 57, 1143-1148.
  37. Do Kyu Pyun, Cheol Hae Lee, Hyun-Joon Ha, Chan Sun Park, Jae Won Chang, Won Koo Lee., “Synthesis of substituted-(l)-tryptophanols from an enantiomerically pure aziridine-2-methanol”, Org. Lett . 2001, 3, 4197-4199.
  38. Kwang-Deuk Lee, Jang-Min Suh, Jae-Hoon Park, Hyun-Joon Ha, Hwan Geun Choi, Chan Sun Park, Jae Won Chang, Won Koo Lee, Yongkwan Dong, Hoseop Yun., “New synthesis and ring opening of cis-3-alkylaziridine-2-carboxylate”, Tetrahedron. 2001, 57, 8267-8276.
  39. Jae Won Chang, Jae Hyun Bae, Seong-Ho Shin, Chan Sun Park, Daeock Choi, Won Koo Lee., “Synthesis of substituted (D)-phenylalanine derivatives by regioselective reduction of enantiomerically pure cis-2, 3-disubstituted aziridines”, Tetrahedron Letters. 1998, 39, 9193-9196.

Books & Chapters:

  1. Alexander Adibekian, Brent R. Martin, Jae Won Chang, Ku-Lung Hsu, Katsunori Tsuboi, Daniel A. Bachovchin, Anna E. Speers, Steven J. Brown, Timothy Spicer, Virneliz Fernandez-Vega, Jill Ferguson, Benjamin F. Cravatt, Peter S. Hodder, Hugh Rosen., "Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2)”, 2014 Jan 13, Probe Reports from the NIH Molecular Libraries Program. PMID: 24624468.
  2. Alexander Adibekian, Brent R. Martin, Jae Won Chang, Ku-Lung Hsu, Katsunori Tsuboi, Daniel A. Bachovchin, Anna E. Speers, Steven J. Brown, Timothy Spicer, Virneliz Fernandez-Vega, Jill Ferguson, Benjamin F. Cravatt, Peter S. Hodder, Hugh Rosen., "Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 1 (LYPLA1)”, 2014 Jan 13, Probe Reports from the NIH Molecular Libraries Program. PMID: 24624465.

Patents:

  1. Cisar, Justin S; Grice, Chery A; Jones, Todd K; Wang, Dong-Hui; Weber, Olivia; Cravat, Benjamin F; Niphakis, Micah J; Cognetta, Armand; Chang, Jae Won. "Carbamate compounds and of making and using same" PCT Int. Appl. (2013), WO 2013142307 A1 20130926.
  2. Cisar, Justin S; Grice, Chery A; Jones, Todd K; Niphakis, Micah J; Chang, Jae Won; Lum, Kenneth M; Cravat, Benjamin F. "Preparation of carbamate compounds as modulators of MAGL and/or ABHD6" PCT Int. Appl.(2013), WO 2013103973 A1 20130711.
  3. Cravatt, Benjamin F; Nomura, Daniel K; Chang, Jae Won; Moellering, Raymond E; Bachovchin, Dan; Li, Weiwei. "Carbamates as serine hydrolase inhibitors and anticancer agents and their preparation" PCT Int. Appl. (2012), WO 2012058115 A2 20120503.
  4. Cravatt BF, Nomura DK, Chang, Jae Won. Anti-cancer carbamates identified by library versus library screening. United States Provisional Patent. (2011), Docket No.: SLW 1361.160pv2.
  5. Choi, Hwan Geun; Sim, Taebo; Gray, Nathanael; Zhou, Wenjun; Chang, Jae Won; Zhang, Jianming; Weisberg, Ellen. "Preparation of phenylthiazolopyridine derivatives for use as antitumor agents" PCT Int. Appl. (2010), WO 2010144909 A1 20101216.
  6. Gray, Nathanael; Chang, Jae Won; Zhang, Jianming; Thoreen, Carson C.; Kang, Seong Woo Anthony; Sabatini, David M.; Liu, Qingsong. "Preparation of substituted benzonaphthyridinones as mTOR modulators" PCT Int. Appl. (2010), WO 2010044885 A2 20100422 CAN 152:501357 AN 2010:502890.
  7. Gray, Nathanael S; Zhang, Jianming; Okram, Barun; Deng, Xianming; Chang, Jae Won; Wojciechowski, Amy. “Small molecule myristate inhibitors of bcr-abl and methods of use” PCT Int. Appl. (2009), WO 2009073153 A2 20090611 CAN 151:49314 AN 2009:702995.