Anupam Patgiri, PhD
The Patgiri lab studies how mutations in mitochondrial and other metabolic genes cause devastating neuromuscular disorders to guide potential therapy. Mitochondrial diseases currently have no FDA-approved therapy. Therefore, we are using small molecule and enzyme engineering approaches to reestablish mitochondrial and metabolic homeostasis in cell and animal models of mitochondrial disease. Currently, we are testing the therapeutic potential of (a) correcting biochemical consequences (e.g., redox, bioenergetic) of mutated metabolic genes and (b) selectively eliminating toxic, defective mitochondria in disease. In another project, we are developing strategies to modulate metabolism in the tumor-immune microenvironment to boost the cytotoxicity of immune cells (T cells and macrophages) as anticancer therapeutics. For more information, please visit the Patgiri lab website listed above.
Lab Members:
Abigail Barlett – Postdoctoral Fellow
Alina Baiju – Research Specialist
Enysa Brianna Moore - Research Specialist
Louisa Hanson - Undergraduate
Read more about the Patgiri lab.