The Miller Lab and Affiliates at Pharmacology and Chemical Biology
We seek to discover chemical tools and novel therapeutic agents that probe, perturb, and control the localization of drugs, proteins, and cells. While projects in the lab revolve around this central theme, the objectives of each are unique. For example, using cleavable linker chemistry, we explore (1) the localization and activation of nucleoside-based therapeutics, (2) protein-protein interactions with spatial and temporal resolution, and (3) the physiological trafficking of immune cells. Through this lens, we are focused on providing members of the lab with cutting-edge training in biomedical research at the interface of biology and chemistry, the scientific community with new chemical biology tools, and the medical community, patients, and caregivers with novel therapeutic agents to address unmet medical needs.