Chouhan S., D. Sridaran, C. Weimholt, J. Luo, T. Li, M. C. Hodgson, L. N. Santos, S. Le Sommer, B. Fang, J. M. Koomen, M. Seeliger, C. K. Qu, A. Yart, M. I. Kontaridis, K. Mahajan, and N. P. Mahajan. SHP2 as a Primordial Epigenetic Enzyme Expunges Histone H3 pTyr-54 to Amend Androgen Receptor Homeostasis. Nature Communications. 2024, Jul 4;15(1):5629
Chen C., H. Zheng, S. Ando, K. Araki, P. Zhao, Z. Li, M. L. Ford, R. Ahmed, and C. K. Qu. Mitochondrial metabolic flexibility is critical for CD8 T cell anti-tumor immunity. Science Advances. 2023; 9(49): eadf9522
Zheng H., Q. Li, S. Li, Z. Li, M. Brotto, D. Weiss, D. Prosdocimo, C. Xu, A. Reddy, M. Puchowicz, C. Croniger, X. Zhao, M. N. Weitzmann, M. K. Jain, and C. K. Qu. Loss of PTPMT1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue specific knockout mice. eLife. 2023; 12:RP86944
Zhang R., D. Chen, H. Fan, R. Wu, J. Tu, F. Zhang, M. Wang, H. Zheng, C. K. Qu, S. E. Elf, B. Faubert, Y. Y. He, M. B. Bissonnette, X. Gao, R. J. DeBerardinis, and J. Chen. Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation. Cell Chemical Biology. 2022; 29:1-9.
Yan Y., L. Dong, J. Zhang, K. D. Bunting, E. Stieglitz, M. L. Loh, and C. K. Qu. JMML tumor cells suppress normal hematopoiesis by disrupting hematopoietic stem cell homeostasis through overproduction of IL-1β. Blood Advances. 2021. 6:200-206
Su H., M. Jiang, C. Senevirathne, S. Alri, T. Zhang, J. X. Ferrucio, N. T. Tran, S. M. Liu, G. Han, S. Jin, Y. Zhu, Q. Zhao, Y. Chen, S. Winski, Y. Shen, J. Liu, C. K. Qu, C. Klug, R. Bhatia, Y. Chen, S. Nimer, Y. G. Zheng, J. Jin, H. Deng, D. S. Krause, J. Xiang, A. Verma, M. Luo, X. Zhao. Arginine Methylation of Dual Specificity Phosphatase 4 Controls Cell Differentiation. Cell Reports. 2021; Jul 27;36(4):109421
Hu L., F. Ni, X. Wang, M. E. Fay, K. M. Young, W. A. Lam, T. A. Sulchek, and C. K. Qu. Decreased cell stiffness enhances leukemia development and progression. Leukemia. 2020, Feb 24. doi: 10.1038/s41375-020-0763-7
Ni F., W. M. Yu, X. Wang, M. E. Fay, K. Young, Y. Qiu, W. A. Lam, T. A. Sulchek, T. Cheng, D. T. Scadden, and C. K. Qu. Ptpn21 controls hematopoietic stem cell homeostasis and biomechanics. Cell Stem Cell. 2019; 24:1-13
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Ni F., W. M. Yu, Z. Li, D. K. Graham, L. Jin, S. Kang, M. R. Rossi, S. Li, H. E. Broxmeyer, and C. K. Qu. Critical role of ASCT2-mediated amino acid metabolism in promoting leukemia development and progression. Nature Metabolism. 2019; 1:390-403
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Hayashi Y., Y. Zhang, A. Yokota, X. Yan, J. Liu, K. Choi, B. Li, G. Sashida, Y. Peng, Z. Xu, R. Huang, L. Zhang, G. M. Freudiger, J. Wang, Y. Dong, Y. Zhou, J. Wang, L. Wu, J. Bu, A. Chen, X. Zhao, X. Sun, K. Chetal, A. Olsson, M. Watanabe, L. E. Romick-Rosendale, H. Harada, L. Y. Shih, W. Tse, J. P. Bridges, M. A. Caligiuri, T. Huang, Y. Zheng, D. P. Witte, Q. F. Wang, C. K. Qu, N. Salomonis, H. L. Grimes, S. D. Nimer, Z. Xiao, and G. Huang. Pathobiologic Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discovery. 2018; 8:1438-1457
Jin L., J. Chun, C. Pan, A. Kumar, G. Zhang, Y. Ha, D. Li, G. N. Alesi, Y. Kang, L. Zhou, W. M. Yu, K. R. Magliocca, F. R. Khuri, C. K. Qu, C. Metallo, T. K. Owonikoko, and S. Kang. The PLAG1-GDH1 axis promotes anoikis resistance and tumor metastasis through CamKK2-AMPK signaling in LKB1-deficient lung cancer. Molecular Cell. 2018; 69:87-99
Zheng H., W. M. Yu, J. Shen, S. Kang, D. Hambardzumyan, J. Y. Li, Y. Shen, A. M. Kenney, J. Chen, and C. K. Qu. Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development. Science Advances. 2018; 4: eaat2681.
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Stavrou E. X., C. Fang, K. L. Bane, E. Kucukal, L. V. Nayak, A. Merkulova, S. Izadmehr, M. M. Mumaw, C. C. Reynolds, O. Alhalabi, W. M. Yu, C. K. Qu, U. A. Gurkan, H. J. Meyerson, M. T. Nieman, A. H. Schmaier. Factor XII - uPAR Upregulate Neutrophil Functions to Influence Wound Healing. The Journal of Clinical Investigation. 2018; 128:944-959
Jin L., J. Chun, C. Pan, D. Li, R. Lin, G. N. Alesi, X. Wang, H. B. Kang, L. Song, D. Wang, G. Zhang, J. Fan, T. J. Boggon, L. Zhou, J. Kowalski, C. K. Qu, C. E. Steuer, G. Z. Chen, N. F. Saba, L. H. Boise, T. K. Owonikoko, F. R. Khuri, K. R. Magliocca, D. M. Shin, S. Lonial, and S. Kang. MAST1 drives cisplatin resistance in human cancers by rewiring cRaf independent MEK activation. Cancer Cell. 2018; 34(2):315-330
Zheng H., W. M. Yu, R. R. Waclaw, M. I. Kontaridis, B. G. Neel, and C. K. Qu. Gain-of-function mutations in protein tyrosine phosphatase Ptpn11 (Shp2) induce hydrocephalus in a catalytically-dependent manner. Science Signaling. 2018; 11 (522), eaao1591.
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Dong L., H. Zheng, and C. K. Qu. CCL3 is a key mediator for the leukemogenic effect of Ptpn11 activating mutations in the stem cell microenvironment. Blood. 2017; 130:1471-1474
Liu W., W. M. Yu, J. Zhang, R. J. Chan, M. L. Loh, Z. Zhang, K.D. Bunting, and C. K. Qu. Inhibition of the Gab2/PI3K/mTOR signaling ameliorates the myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations. Leukemia. 2017; 31:1415-1422
Dong, L., W.M. Yu, H. Zheng, M. L. Loh, S. T. Bunting, M. Pauly, G. Huang, M. Zhou, H. E. Broxmeyer, D. T. Scadden, and C. K. Qu. Leukemogenic effects of Ptpn11 (Shp2) activating mutations in the stem cell microenvironment. Nature. 2016; 539:304-308.
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Gu L., H. Zhang, T. Liu, S. Zhou, Y. Du, J. Xiong, S. Yi, C. K. Qu, H. Fu, and M. Zhou. Discovery of dual inhibitors of MDM2 and XIAP for cancer treatment. Cancer Cell. 2016; 30: 623-636
Liu, X., H. Zheng, X. Li, S. Y. Wang, H. J. Meyerson, W. Yang, B. G. Neel, and C. K. Qu. Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113:984-989
Liu, X., H. Zheng, X. Li, S. Y. Wang, H. J. Meyerson, W. Yang, B. G. Neel, and C. K. Qu. Gain-of-function mutations of Ptpn11 (Shp2) cause aberrant mitosis and increase susceptibility to DNA damage-induced malignancies. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113:984-989
Liu, X., H. Zheng, T. M. W. M., Yu, Cooper, K. D. Bunting, and C. K. Qu. Maintenance of hematopoietic stem cells ex vivo by reprograming cellular metabolism. Blood. 2015; 125:1562-1565
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Yu, W. M., X. Liu, J. Shen, J. Jovanovic, E. E. Pohl, S. L. Gerson, T. Finkel, H. E. Broxmeyer, and C. K. Qu. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell. 2013; 12:62-74.
Yu, W. M., X. Liu, J. Shen, J. Jovanovic, E. E. Pohl, S. L. Gerson, T. Finkel, H. E. Broxmeyer, and C. K. Qu. Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell. 2013; 12:62-74.
Liu, X., H. Zheng, and C. K. Qu. Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability. Cancer Research. 2012; 72:5296-5306
Xu, D., X. Liu, W. M. Yu, H. Meyerson, C. Guo, S. L. Gerson, and C. K. Qu. Non-lineage/stage restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on leukemia stem cell development. The Journal of Experi
Xu, D., S. Wang, W. M. Yu, Chan, T. Araki, K. D. Bunting, B. G. Neel, and C. K. Qu. A germline gain-of-function mutation in Ptpn11 (Shp2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells. Blood. 2010; 116:3611-3621
Shen, J., W. M. Yu, M. Brotto, J. A. Scherman, C. Guo, C. Stoddard, T. M. Nosek, H. H. Valdivia, and C. K. Qu. Deficiency of phosphatidylinositol phosphate phosphatase MIP/MTMR14 induces a muscle disorder by disrupting Ca2+ homeostasis. Nature Cell Biology. 2009; 11:769-776.
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