Emory University School of Medicine
Emory University School of Medicine
Department of Neurosurgery

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Department of Neurosurgery

Publications

For a complete and updated list of Dr. Nduom's publications, please visit his NIH Bibliography page.


Immunotherapy for Brain Tumors

  • Xu S, Wei J, Wang F, Kong LY, Ling XY, Nduom E, Gabrusiewicz K, Doucette T, Yang Y, Yaghi NK, Fajt V, Levine JM, Qiao W, Li XG, Lang FF, Rao G, Fuller GN, Calin GA, Heimberger AB. Effect of miR-142-3p on the M2 macrophage and therapeutic efficacy against murine glioblastoma. J Natl Cancer Inst. 2014 Aug;106(8). doi: 10.1093/jnci/dju162. Print 2014 Aug. PubMed PMID: 24974128; PubMed Central PMCID: PMC4271080.
  • Nduom EK, Weller M, Heimberger AB. Immunosuppressive mechanisms in glioblastoma. Neuro Oncol. 2015 Nov;17 Suppl 7:vii9-vii14. doi: 10.1093/neuonc/nov151. Review. PubMed PMID: 26516226; PubMed Central PMCID: PMC4625890.
  • Nduom EK, Wei J, Yaghi NK, Huang N, Kong LY, Gabrusiewicz K, Ling X, Zhou S, Ivan C, Chen JQ, Burks JK, Fuller GN, Calin GA, Conrad CA, Creasy C, Ritthipichai K, Radvanyi L, Heimberger AB. PD-L1 expression and prognostic impact in glioblastoma. Neuro Oncol. 2016 Feb;18(2):195-205. doi: 10.1093/neuonc/nov172. Epub 2015 Aug 30. PubMed PMID: 26323609; PubMed Central PMCID: PMC4724183.
  • Wei J, Nduom EK, Kong LY, Hashimoto Y, Xu S, Gabrusiewicz K, Ling X, Huang N, Qiao W, Zhou S, Ivan C, Fuller GN, Gilbert MR, Overwijk W, Calin GA, Heimberger AB. MiR-138 exerts anti-glioma efficacy by targeting immune checkpoints. Neuro Oncol. 2016 May;18(5):639-48. doi: 10.1093/neuonc/nov292. Epub 2015 Dec 11. PubMed PMID: 26658052; PubMed Central PMCID: PMC4827047.
  • Yaghi NK, Wei J, Hashimoto Y, Kong LY, Gabrusiewicz K, Nduom EK, Ling X, Huang N, Zhou S, Kerrigan BC, Levine JM, Fajt VR, Levine G, Porter BF, Marcusson EG, Tachikawa K, Chivukula P, Webb DC, Payne JE, Heimberger AB. Immune modulatory nanoparticle therapeutics for intracerebral glioma. Neuro Oncol. 2017 Mar 1;19(3):372-382. doi: 10.1093/neuonc/now198. PubMed PMID: 27765835; PubMed Central PMCID: PMC5464307.
  • Ranjan S, Quezado M, Garren N, Boris L, Siegel C, Lopes Abath Neto O, Theeler BJ, Park DM, Nduom E, Zaghloul KA, Gilbert MR, Wu J. Clinical decision making in the era of immunotherapy for high grade-glioma: report of four cases. BMC Cancer. 2018 Mar 1;18(1):239. doi: 10.1186/s12885-018-4131-1. PubMed PMID: 29490632; PubMed Central PMCID: PMC5831705. 
  • Lynes J, Sanchez V, Dominah G, Nwankwo A, Nduom E. Current Options and Future Directions in Immune Therapy for Glioblastoma. Front Oncol. 2018;8:578. doi: 10.3389/fonc.2018.00578. eCollection 2018. Review. PubMed PMID: 30568917; PubMed Central PMCID: PMC6290347.
  • Lynes J, Jackson S, Sanchez V, Dominah G, Wang X, Kuek A, Hayes CP, Benzo S, Scott GC, Chittiboina P, Zaghloul KA, Park DM, Wu J, Hourigan CS, Giles AJ, Wu T, Maric D, Chen J, Quezado M, Heiss JD, Gilbert MR, Nduom EK. Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade. Neurosurgery. 2019 Apr 1;84(4):945-953. doi: 10.1093/neuros/nyy392. PubMed PMID: 30189044; PubMed Central PMCID: PMC6500883.
  • Pratt D, Dominah G, Lobel G, Obungu A, Lynes J, Sanchez V, Adamstein N, Wang X, Edwards NA, Wu T, Maric D, Giles AJ, Gilbert MR, Quezado M, Nduom EK. Programmed Death Ligand 1 Is a Negative Prognostic Marker in Recurrent Isocitrate Dehydrogenase-Wildtype Glioblastoma. Neurosurgery. 2019 Aug 1;85(2):280-289. doi: 10.1093/neuros/nyy268. PubMed PMID: 30011045; PubMed Central PMCID: PMC7137460.
  • Giles AJ, Hao S, Padget M, Song H, Zhang W, Lynes J, Sanchez V, Liu Y, Jung J, Cao X, Fujii R, Jensen R, Gillespie D, Schlom J, Gilbert MR, Nduom EK, Yang C, Lee JH, Soon-Shiong P, Hodge JW, Park DM. Efficient ADCC killing of meningioma by avelumab and a high-affinity natural killer cell line, haNK. JCI Insight. 2019 Oct 17;4(20). doi: 10.1172/jci.insight.130688. PubMed PMID: 31536478; PubMed Central PMCID: PMC6824312.
  • Lynes JP, Nwankwo AK, Sur HP, Sanchez VE, Sarpong KA, Ariyo OI, Dominah GA, Nduom EK. Biomarkers for immunotherapy for treatment of glioblastoma. J Immunother Cancer. 2020 May;8(1). doi: 10.1136/jitc-2019-000348. Review. PubMed PMID: 32474411; PubMed Central PMCID: PMC7264836.
  • Sanchez VE, Lynes JP, Walbridge S, Wang X, Edwards NA, Nwankwo AK, Sur HP, Dominah GA, Obungu A, Adamstein N, Dagur PK, Maric D, Munasinghe J, Heiss JD, Nduom EK. GL261 luciferase-expressing cells elicit an anti-tumor immune response: an evaluation of murine glioma models. Sci Rep. 2020 Jul 3;10(1):11003. doi: 10.1038/s41598-020-67411-w. PubMed PMID: 32620877; PubMed Central PMCID: PMC7335060.
  • Medina R, Wang H, Caisová V, Cui J, Indig IH, Uher O, Ye J, Nwankwo A, Sanchez V, Wu T, Nduom E, Heiss J, Gilbert MR, Terabe M, Ho W, Zenka J, Pacak K, Zhuang Z. Induction of Immune Response Against Metastatic Tumors via Vaccination of Mannan-BAM, TLR Ligands and Anti-CD40 Antibody (MBTA). Adv Ther (Weinh). 2020 Sep;3(9). doi: 10.1002/adtp.202000044. Epub 2020 Jun 9. PubMed PMID: 33709018; PubMed Central PMCID: PMC7942838.
  • Yu G, Butler MK, Abdelmaksoud A, Pang Y, Su YT, Rae Z, Dadkhah K, Kelly MC, Song YK, Wei JS, Terabe M, Atony R, Mentges K, Theeler BJ, Penas-Prado M, Butman J, Camphausen K, Zaghloul KA, Nduom E, Quezado M, Aldape K, Armstrong TS, Gilbert MR, Gulley JL, Khan J, Wu J. Case Report: Single-Cell Transcriptomic Analysis of an Anaplastic Oligodendroglioma Post Immunotherapy. Front Oncol. 2020;10:601452. doi: 10.3389/fonc.2020.601452. eCollection 2020. PubMed PMID: 33520712; PubMed Central PMCID: PMC7841290.


Other Laboratory Investigations and Reviews

  • Platt S, Nduom E, Kent M, Freeman C, Machaidze R, Kaluzova M, Wang L, Mao H, Hadjipanayis CG. Canine model of convection-enhanced delivery of cetuximab-conjugated iron-oxide nanoparticles monitored with magnetic resonance imaging. Clin Neurosurg. 2012;59:107-13. doi: 10.1227/NEU.0b013e31826989ef. PubMed PMID: 22960522; PubMed Central PMCID: PMC3473085.
  • Nduom EK, Bouras A, Kaluzova M, Hadjipanayis CG. Nanotechnology applications for glioblastoma. Neurosurg Clin N Am. 2012 Jul;23(3):439-49. doi: 10.1016/j.nec.2012.04.006. Epub 2012 Jun 14. Review. PubMed PMID: 22748656; PubMed Central PMCID: PMC3473084.
  • Nduom EK, Walbridge S, Lonser RR. Comparison of pulsed versus continuous convective flow for central nervous system tissue perfusion: laboratory investigation. J Neurosurg. 2012 Dec;117(6):1150-4. doi: 10.3171/2012.9.JNS12506. Epub 2012 Oct 12. PubMed PMID: 23061389; PubMed Central PMCID: PMC4746716.
  • Nduom EK, Yang C, Merrill MJ, Zhuang Z, Lonser RR. Characterization of the blood-brain barrier of metastatic and primary malignant neoplasms. J Neurosurg. 2013 Aug;119(2):427-33. doi: 10.3171/2013.3.JNS122226. Epub 2013 Apr 26. PubMed PMID: 23621605; PubMed Central PMCID: PMC4746720.
  • Nduom EK, Zhuang Z, Lonser RR. Blood-brain barrier. Response. J Neurosurg. 2014 Jan;120(1):291. PubMed PMID: 24520575; PubMed Central PMCID: PMC4762061.
  • Nduom EK, Hadjipanayis CG, Van Meir EG. Glioblastoma cancer stem-like cells: implications for pathogenesis and treatment. Cancer J. 2012 Jan-Feb;18(1):100-6. doi: 10.1097/PPO.0b013e3182452e0d. Review. PubMed PMID: 22290263; PubMed Central PMCID: PMC3269658.


Other Clinical Investigations

  • Oddo M, Nduom E, Frangos S, MacKenzie L, Chen I, Maloney-Wilensky E, Kofke WA, Levine JM, LeRoux PD. Acute lung injury is an independent risk factor for brain hypoxia after severe traumatic brain injury. Neurosurgery. 2010 Aug;67(2):338-44. doi: 10.1227/01.NEU.0000371979.48809.D9. PubMed PMID: 20644419.
  • Butman JA, Nduom E, Kim HJ, Lonser RR. Imaging detection of endolymphatic sac tumor-associated hydrops. J Neurosurg. 2013 Aug;119(2):406-11. doi: 10.3171/2013.2.JNS12608. Epub 2013 Mar 8. PubMed PMID: 23472846.
  • Jackson S, Weingart J, Nduom EK, Harfi TT, George RT, McAreavey D, Ye X, Anders NM, Peer C, Figg WD, Gilbert M, Rudek MA, Grossman SA. The effect of an adenosine A2A agonist on intra-tumoral concentrations of temozolomide in patients with recurrent glioblastoma. Fluids Barriers CNS. 2018 Jan 15;15(1):2. doi: 10.1186/s12987-017-0088-8. PubMed PMID: 29332604; PubMed Central PMCID: PMC5767971.
  • Lynes J, Acquaye AA, Sur H, Nwankwo A, Sanchez V, Vera E, Wu T, Theeler B, Armstrong TS, Gilbert MR, Nduom EK. Variations in attitudes towards stereotactic biopsy of adult diffuse midline glioma patients: a survey of members of the AANS/CNS Tumor Section. J Neurooncol. 2020 Aug;149(1):161-170. doi: 10.1007/s11060-020-03585-7. Epub 2020 Jul 23. PubMed PMID: 32705457; PubMed Central PMCID: PMC7452882.
  • Nduom EK, Olson JJ. Metastases to the Central Nervous System: A Comprehensive Guide on Current Management and Future Directions. Neurosurg Clin N Am. 2020 Oct;31(4):xiii-xiv. doi: 10.1016/j.nec.2020.07.001. Epub 2020 Aug 15. PubMed PMID: 32921361.


Operative Techniques

  • Nduom EK, Sribnick EA, Ormond DR, Hadjipanayis CG. Neuroendoscopic Resection of Intraventricular Tumors and Cysts through a Working Channel with a Variable Aspiration Tissue Resector: A Feasibility and Safety Study. Minim Invasive Surg. 2013;2013:471805. doi: 10.1155/2013/471805. Epub 2013 Jun 13. PubMed PMID: 23844287; PubMed Central PMCID: PMC3697810.
  • Mastorakos P, Lynes J, Maggio D, Quezado MM, Nduom EK. Resection of Myxopapillary Ependymoma of the Filum Terminale: 2-Dimensional Operative Video. Oper Neurosurg (Hagerstown). 2020 Feb 1;18(2):E40. doi: 10.1093/ons/opz099. PubMed PMID: 31073602; PubMed Central PMCID: PMC7594178.


Leadership and Advocacy

  • Linzey JR, Sivakumar W, Johnson JN, Ivan ME, Haider AS, Philips CA, Than KD, Tomei KL, Muraszko KM, Nduom EK. Young Neurosurgeons Committee of the American Association of Neurological Surgeons: Training Ground for Future Leaders in Organized Neurosurgery in the United States of America. World Neurosurg. 2019 Mar;123:59-63. doi: 10.1016/j.wneu.2018.11.206. Epub 2018 Dec 7. Review. PubMed PMID: 30529528; PubMed Central PMCID: PMC6401290.
  • Feliciano JT, Salmi L, Blotner C, Hayden A, Nduom EK, Kwan BM, Katz MS, Claus EB. Brain Tumor Discussions on Twitter (#BTSM): Social Network Analysis. J Med Internet Res. 2020 Oct 8;22(10):e22005. doi: 10.2196/22005. PubMed PMID: 33030435; PubMed Central PMCID: PMC7582142.
  • Balogun J, Haynes C, Lwin Z, Nduom E, Puduvalli V, Venere M, Zadeh G. SNO 25th anniversary history series: Providing a global platform for communication and exchange in neuro-oncology. Neuro Oncol. 2020 Nov 26;22(11):1551-1552. doi: 10.1093/neuonc/noaa219. PubMed PMID: 32995879; PubMed Central PMCID: PMC7690359.
  • Detchou DK, Onyewuenyi A, Reddy V, Boyke A, Mbabuike N, Ashley WW, Nduom EK. Letter: A Call to Action: Increasing Black Representation in Neurological Surgery. Neurosurgery. 2021 Feb 20;. doi: 10.1093/neuros/nyab057. [Epub ahead of print] PubMed PMID: 33611592.