Education
- FIRST Postdoctoral Fellow, Biology, Emory College of Arts and Sciences, Atlanta, GA, 2019 - present
- PhD, Biomedical Sciences, Eastern Virginia Medical School, Norfolk, VA, 2019
- BS, Chemical Engineering, University of Virginia, Charlottesville, VA, 2005
Research
Research Title: The critical ciliary role of ARL13B in kidney cystogenesis.
To understand the kidney-specific signaling mechanisms of the cilia protein ARL13B in mouse models of PKD. Ciliary proteins appear to play a major role in kidney cystogenesis, but the pathway driving renal cystogenesis is unknown. Recent genetic evidence implicates ciliary ARL13B in playing a critical role in modulating renal cystogenesis.
Research Mentor: Tamara Caspary, PhD, Professor, Emory University School of Medicine, Department of Human Genetics
Publications
- Van Sciver, R.E.*, Lee, M.P.*, Lee, C.D., Lafever, A.C., Svyatova, E., Kanda, K., Colliver, A.L., van Reesema, L.L.S., Tang-Tan, A.M., Zheleva, V., Bwayi, M.N., Bian, M., Schmidt, R.L., Matrisian, L.M., Petersen, G.M., Tang, A.H. (2018) A New Strategy to Control and Eradicate “Undruggable” Oncogenic K-RAS-Driven Pancreatic Cancer : Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology. Cancers (Basel). 10(5). pii: E142. PMID: 29757973 DOI:10.3390/cancers10050142.
- Pepper, I.J., Van Sciver, R.E., Tang, A.H. (2017) Phylogenetic Analysis of the SINA/SIAH Ubiquitin E3 Ligase Family in Metazoa. BMC Evol Biol.17(1):182. PMID: 28784114 DOI: 10.1186/s12862-017-1024-x
- Jananji, S., Risi, C., Lindamulage, I.K., Picard, L.P., Van Sciver, R., Laflamme, G., Albaghjati, A., Hickson, G.R., Kwok, B.H., Galkin, V.E. (2017) Multimodal and polymorphic interactions between anillin and actin: Their implications for cytokinesis. J Mol Biol. 429 (5): 715–31. PMID: 28147230 DOI:10.1016/j.jmb.2017.01.020
- Gildea, J.J., Van Sciver, R.E., McGrath, H.E., Kemp, B.A., Jose, P.A., Carey, R.M., Felder, R.A. Dopaminergic immunofluorescence studies in kidney tissue. Methods Mol Biol.2017;1527:151-161. PMID: 28116714 DOI:10.1007/978-1-4939-6625-7_12
- Van Sciver, R.E.*, Njogu, M.M.*, Isbell, A.J., Odanga, J.J., Bian, M., Svyatova, E., Siewertsz van Reesema, L.L., Zheleva, V., Eisner, J.L., Bruflat, J.K., Schmidt, R.L., Tang-Tan, A.M., Tang, A.H. (2017) Blocking SIAH Proteolysis, an Important K-RAS Vulnerability, to Control and Eradicate K-RAS-Driven Metastatic Cancer. in Conquering RAS: Biology to Cancer Therapy.213-232. DOI: 10.1016/B978-0-12-803505-4.00012-6
- Siewertsz van Reesema, L.L.*, Zheleva, V.*, Winston, J.S.*, Jansen, R.J., O’Connor, C.F., Isbell, A.J., Bian, M., Qin, R., Bassett, P.T., Hinson, V.J., Dorsch, K.A., Kirby, B.W., Van Sciver, R.E., Tang-Tan, A.M., Harden, E.A., Chang, D.Z., Allen, C.A., Perry, R.R., Hoefer, R.A., Tang, A.H. (2016) SIAH and EGFR, two RAS pathway biomarkers, are prognostic in locally advanced and metastatic breast cancer. 11: 183-98. PMID: 27569656 DOI: 10.1016/j.ebiom.2016.08.014
- Harris, S.P., Belknap, B., Van Sciver, R.E., White, H.D., Galkin, V.E. (2016) C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation. Proc Natl Acad Sci.113(6):1558-63. PMID: 26831109 DOI: 10.1073/pnas.1518891113
- Gildea, J.J., Seaton, J.E., Victor, K.G., Reyes, C.M., Bigler Wang, D., Pettigrew, A.C., Courtner, C.E., Shah, N., Tran, H.T., Van Sciver, R.E., Carlson, J.M., Felder, R.A. (2014) Exosomal Transfer from Human Renal Proximal Tubule Cells to Distal Tubule and Collecting Duct Cells. Biochem. 47(15):89-94. PMID:24976626 DOI:10.1016/j.clinbiochem.2014.06.018
- Gildea, J.J., Shah, I.T., Van Sciver, R.E., Israel, J.A., Enzensperger, C., McGrath, H.E., Jose, P.A., Felder, R.A. (2014) The cooperative roles of the dopamine receptors, D1R and D5R, on the regulation of renal sodium transport. Kidney Int.86(1):118-26. PMID: 24552847 DOI: 10.1038/ki.2014.5
- Gildea, J.J., Lahiff, D.T., Van Sciver, R.E., Weiss, R.S., Shah, N., McGrath, H.E., Schoeffel, C.D., Jose, P.A., Carey, R.M., Felder, R.A. (2013) A linear relationship between the ex-vivo sodium mediated expression of two sodium regulatory pathways as a surrogate marker of salt sensitivity of blood pressure in exfoliated human renal proximal tubule cells: the virtual renal biopsy. Clin Chim Acta. 421:236-42. PMID: 23454474 DOI: 10.1016/j.cca.2013.02.021
- Gildea, J.J., Tran, H.T., Van Sciver, R.E., Bigler Wang, D., Carlson, J.M., Felder, R.A. (2013) A novel role for c-Myc in G protein-coupled receptor kinase 4 (GRK4) transcriptional regulation in human kidney proximal tubule cells. 61(5):1021-7. PMID: 23509080 DOI:10.1161/HYPERTENSIONAHA.111.00321
- Gildea, J.J., McGrath, H.E., Van Sciver, R.E., Wang, D.B., Felder, R.A. (2013) Isolation, growth, and characterization of human renal epithelial cells using traditional and 3D methods. Methods Mol Biol.945:329-45. PMID: 23097116 DOI: 10.1007/978-1-62703-125-7_20
- Gildea, J.J., Wang, X., Shah, N., Tran, H., Spinosa, M., Van Sciver, R., Sasaki, M., Yatabe, J., Carey, R.M., Jose, P.A., Felder, R.A. (2012) Dopamine and Angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells. 60(2):396-403. PMID: 22710646 DOI:10.1161/HYPERTENSIONAHA.112.194175
- Gildea, J.J., Kemp, B.A., Howell, N.L., Van Sciver, R.E., Carey, R.M., Felder, R.A. (2011) Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats. Am J Physiol Renal Physiol.300(4):F914-20. PMID: 21289050 DOI: 10.1152/ajprenal.00380.2010