Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory (UM1 AI164566)
The immediate establishment of the latent HIV-1 reservoir in resting memory CD4+ T cells precludes HIV-1 cure, compelling ART for a lifetime in children.
Immune Determinants Of Pediatric HIV/SIV Reservoir Establishment And Maintenance (P01 HD112217)
New perinatal HIV infections continue, at a rate of about one every 3-4 minutes, 400 every day, and 3000 every week.
Enhanced Latency Reversal And Reservoir Clearance In Macaques (R37 AI157862)
Current treatment for HIV infection requires strict adherence to daily antiretroviral therapy (ART). ART has greatly reduced mortality and morbidity but is not a cure.
Virus and host directed immunotherapies for cure in SHIV-infected infant macaques (R01AI192330)
New perinatal HIV infections continue, at a rate of about one every 4 minutes. Treatment with antiretroviral therapy (ART) limits the size of the persistent reservoir in children but also limits the development of antiviral immune responses.
Neurodevelopment After Postnatal Zika Virus Infection In Infant Macaques (R01 NS120182)
Intense research has focused on the neurologic effects of prenatal Zika virus (ZIKV) infection; however, the consequences of postnatal infection early in life are understudied.