September 2021
Conference Presentation: Germán G. Vargas-Cuebas Speaks at the 12th International Conference on the Molecular Biology and Pathogenesis of the Clostridia
August 2021
New Lab Member: Zavier Carter joined the McBride lab in August 2021 as a research specialist
August 2021
New Lab Member: Christopher M. Kim joins the McBride Lab as an undergraduate student
August 2021
New Lab Member: Marcos Monteiro joins the lab as a graduate student
June 2021
New Fellowship: Cheyenne Lee became an ARTDTP Fellow
May 2021
New lab member: Germán Vargas-Cuebas joins the lab as a graduate student in Microbiology and Molecular Genetics program.
December 2020
New Award: Germán G. Vargas-Cuebas is awarded an F31 (NIDDK): Start date December 1st, 2020
August 2020
New Lab Member: Cheyenne Lee joins the lab in the Microbiology and Molecular Genetics program.
June 2020
New Fellowship: Germán G. Vargas-Cuebas becomes an ARTDTP Fellow
July 2018
Article: PLoS Pathogens 2018 Aug
The C. difficile clnRAB operon initiates adaptations to the host environment in response to LL-37
January 2011
Article: Infect Immun 79(1):167-76
Identification of a Genetic Locus Responsible for Antimicrobial Peptide Resistance in Clostridium difficile.
January 2011
Dr. McBride joins the Department of Microbiology and Immunology as an assistant professor. Her lab research focuses on identifying and understanding the genetic mechanisms used by the pathogen Clostridium difficile to subvert host defenses and survive within the mammalian intestine. Studies focus on two distinct aspects of C. difficile infections: the resistance of the bacterium to antimicrobial peptides and the formation of dormant spores in the host.
February 2011
Article: Curr Protoc Microbiol. 20:9A.2.1-9A.2.17
Genetic Manipulation of Clostridium difficile.
May 2011
Article: Microbiol 157(5):1457-65
The dlt Operon Confers Resistance to Cationic Antimicrobial Peptides in Clostridium difficile.
October 2011
New Lab Member: Jose Suarez joined the McBride Lab from October 1, 2011 — May 31, 2014.
January 2012
The McBride Lab’s Official Mascott: C. Diff the Seal
July 2012
Article: J Bacteriol 194(13):3307-16
Cyclic diguanylate inversely regulates motility and aggregation in Clostridium difficile.
August 2012
New Lab Member: Adrianne Edwards joined the lab as Instructor.
January 2013
Article: J Bacteriol 195(6):1204-13
Identification of CodY-targets in Bacillus anthracis by genome-wide in vitro binding analysis.
January 2013
New Lab Member: Katie Nawrocki, January 24, 2013 — November 15, 2016
March 2013
Article: J Bacteriol 195(11):2621-31
The Clostridium difficile cpr Locus is Regulated by a Non-contiguous Two-component System in Response to Type A and B Lantibiotics.
May 2013
New Lab Member: Silvia Dimitrova joined the McBride Lab from May 1, 2013 — October 28, 2013.
September 2013
Article: J Vis Exp (79), e50787
Culturing and Maintaining Clostridium difficile in an Anaerobic Environment.
November 2013
New Lab Member: Kevin Childress joined the lab from November 12, 2013 — July 31, 2015.
April 2014
Article: Microbe Apr2014
More Than One Way to Make a Spore
May 2014
New Lab member: Emily Woods joined the McBride lab from May 28, 2014 — May 1, 2018.
June 2014
Article: FEMS Micro Lett 9Jun2014
Initiation of Sporulation in Clostridium difficile: a Twist on the Classic Model.
July 2014
Article: Infect Immun 28Jul2014
Conserved Oligopeptide Permeases Modulate Sporulation Initiation in Clostridium difficile.
September 2014
New Lab Member: Christine Tien joined the lab from September 2, 2014 — May 31, 2017.
October 2014
Article: JACS 3Oct2014
Synthetic Polymers Active Against Clostridium difficile Vegetative Cell Growth and Spore Outgrowth.
October 2014
Article: Antibiotics 3(4):461-492
Mechanisms of Antimicrobial Peptide Resistance in Gram-positive Bacteria
October 2014
New Rotation Student: Sarah Anderson, October 13, 2014 — December 18, 2014.
November 2014
Article: PLoS ONE 12Nov2014
Functional Heterologous Protein Expression by Genetically Engineered Probiotic Yeast Saccharomyces boulardii
January 2015
Article: Anaerobe 7Jan2015
An Alkaline Phosphatase Reporter for use in Clostridium difficile
January 2015
New Undergraduate Research Assistant: Samiha Karim, January 30, 2015 — April 13, 2020.
May 2015
Article: Antimicrob Agents Chemother. 59(7):4199-205
Effects of Surotomycin on Clostridium difficile Viability and Toxin Production in vitro
May 2015
New Graduate Student: Sarah Anderson, May 1, 2015 — November 1, 2016.
November 2015
New Undergraduate Research Assistant: Lina Jowhar, November 29, 2015 — April 13, 2020,
December 2015
Article: Anaerobe 11 Dec 2015
Immunogenicity and Protective Efficacy of Clostridium difficile Spore Proteins
January 2016
New Rotation Student: Jessie Wozniak, January 4, 2016 — March 11, 2016.
February 2016
Article: Emerg Microbe Infect
Immunogenicity and Protective Efficacy of Recombinant Clostridium difficile Flagellar protein FliC
February 2016
Article: Mol Microbiol
A Novel Regulator Controls Clostridium difficile Sporulation, Motility and Toxin Production
April 2016
Article: Infect Immun 11Apr2016
The Clostridium difficile Dlt pathway is controlled by the ECF sigma factor, σV, in response to lysozyme
May 2016
New Lab Member: Virginia Vachon, May 1, 2016 — August 31, 2016 .
May 2016
Article: J Bacteriol 31May2016
CodY-dependent regulation of sporulation in Clostridium difficile
August 2016
Article: Meth Mol Biol
Isolating and Purifying Clostridium difficile Spores
September 2016
Undergraduate Research Asst.: Kavita Athalye in McBride Lab, September 9, 2016 — January 17, 2017.
June 2018
Article: Anaerobe 2018 Jun22
Examination of the Clostridioides (Clostridium) difficile VanZ ortholog, CD1240
September 2016
Article: Virulence 2016 Sep 21
What’s a SNP between friends: the influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives
October 2016
Article: Front Microbiol 26 Oct 2016
Chemical and Stress Resistances of Clostridium difficile Spores and Vegetative Cells
November 2016
New Lab Member: Research Specialist Josh Jones joins the McBride Lab.
November 2016
Rotation student: Ogie Avramovska rotated in the McBride Lab November 21, 2016 — January 27, 2017.
February 2017
Article: Bioprotocols 2017 Feb 5
Determination of the in vitro Sporulation Frequency of Clostridium difficile
February 2017
New Lab Member: Monjori Mukerjee joined the McBride Lab as an Undergraduate Research Assistant, February 8, 2017 — May 1, 2018.
April 2017
Article: Genome Announc 2017 Apr 6
Genome sequence of a toxin-positive Clostridium difficile strain isolated from murine feces
May 2017
New Lab Member: Daniela Wetzel, PhD, joined the McBride Lab as a Postdoctoral Fellow.
June 2017
Article: Infect Immun 2017Jun26
A nutrient-regulated cyclic diguanylate phosphodiesterase controls Clostridium difficile biofilm and toxin production during stationary phase
September 2017
New Lab Member: Grace Swaim rotated as an Undergraduate Research Assistant in the McBride Lab from September 2017 — February 2018.
September 2017
New Lab Member: Michael DiCandia rotated in the McBride Lab from September 2017 — November 2017.
November 2017
New Lab Member: Brenda Antezana rotated in the McBride Lab from November 2017 — January 2018.
January 2018
Article: Envron Microbiol 2018 Jan9
Ethanolamine is a Valuable Nutrient Source that Impacts Clostridium difficile Pathogenesis
February 2018
New Lab Membert: Megan Woods rotated in the McBride Lab from February 2018 — March 2018.
April 2018
New Lab Member: Michael DiCandia joined the lab as a Graduate Student.
May 2018
New Lab Member: Germ an Vargas-Cuebas joined the lab as a Graduate Student.