Welcome to Our Clinical Trial Site!
Low Dose Naltrexone for the Treatment of Chronic Neuropathic Pain in Patients with Human Immunodeficiency Virus (HIV): a Prospective, Pragmatic, Open Label Clinical Trial
ClinicalTrials.gov ID: NCT05537935
Study Background & FAQsAbout Our Study
Who Are We?
Contact Us
Study Progress and Results
Study Background & FAQs
What is a clinical trial?
Per the National Institutes of Health: - “Clinical trials are research studies that test a medical, surgical, or behavioral intervention in people. These trials are the primary way that researchers determine if a new form of treatment or prevention, such as a new drug, diet, or medical device (for example, a pacemaker), is safe and effective in people. Often, a clinical trial is designed to learn if a new treatment is more effective or has less harmful side effects than existing treatments.”
What is the purpose of this clinical trial?
The purpose of this study is to investigate how well low dose naltrexone (LDN) works to treat neuropathic pain in patients living with HIV. - As medication options for patients living with HIV improve, these patients are living longer and alsoexperiencing more chronic conditions, including chronic
- Current pain treatments often include opioids, which can have other negative consequences
- We think LDN will provide an effective alternative to treat chronic, neuropathic pain in patients living with HIV. This study aims to gain scientific evidence about LDN as a neuropathic pain reliever.
What is Low-Dose Naltrexone (LDN)?
- Naltrexone is an FDA-approved medication for addiction treatment. It’s an opioid antagonist and works by preventing the “high” feeling that can accompany use of opioids and alcohol.
- Low dose naltrexone (LDN) is administered at 1-5 mg daily, whereas a standard naltrexone dose is 50 mg daily.
- LDN has been shown to be effective for the treatment of chronic pain, including neuropathic pain.
Does LDN cause side effects?
- Side effects of Low Dose Naltrexone are very rare.
- People sometimes report having vivid dreams in the first week or two of treatment.
- Very rare side effects include fatigue, anxiety, and dizziness.