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Hyunsuk Shim, Ph.D.

Curriculum Vitae

Biographical Section

Name: Hyunsuk Shim
Degree(s): Ph.D.
Office Address: 1701 Uppergate Drive, Clinic C5008
Atlanta, GA 30322
Telephone: (404) 778-4564 (Office)
Fax:
Email Address: hshim@emory.edu (University)

Current Primary Academic Appointments

Hire Date: 01/2002 - Current Professor Radiology and Imaging Sciences Emory University School of Medicine Atlanta, GA

Current Joint & Secondary Appointments  

01/2002 - Current Assistant Professor Radiology Emory University

Current Clinical Appointments  

Current Administrative Appointments  

Previous Academic Appointments  

09/2001 - 12/2001 Director of Molecular Targeting Program Radiology Department Johns Hopkins, School of Medicine
05/1998 - 08/2001 Instructor Department of Medicine Johns Hopkins, School of Medicine

Previous Clinical Appointments  

Previous Administrative Appointments  

Licensure & Board Certifications  

Specialty Boards  

Education  

1992 Ph.D., Biophysics University of Illinois at Urbana-Champaign Champaign, IL, USA

Postgraduate Training  

05/1995 - 04/1997 Post-doc Department of Medicine, Johns Hopkins, School of Medicine Chi Dang
05/1992 - 04/1995 Post-doc Radiology Department, Johns Hopkins, School of Medicine Jerry Glickson

Military/Government Service  

National & International Committee Memberships  

07/2004 - Current Susan G. Komen Foundation Grant Review Reviewer
09/2005 - Current Department of Defense, Study section reviewer
10/2005 - Current NIH Study Section Reviewer

State & Regional Committee Memberships  

Institutional Committee Memberships  

04/2004 - Current IACUC Voting member

Consultantships  

Editorships & Editorial Boards  

Manuscript Reviewer  

Honors & Awards  

Society Memberships  

Organization of National/International Conferences: Administrative Positions  

Organization of National/International Conferences: Sessions as Chair  

Research Focus  

The chemokine receptor, CXCR4 is one of critical factors for breast cancer metastasis by interacting with its ligand, stromal cell derived factor 1 (SDF-1). SDF-1 is expressed in destinations of breast cancer metastasis, including lymph node, lung, liver, and bone marrow. CXCR4 expression is low in normal breast tissues and high in malignant tumors. Dr. Shims laboratory developed CXCR4 antagonist, which inhibits CXCR4/SDF-1 mediated invasion with high specificity. Using an experimental animal model for metastasis, the CXCR4 antagonist blocked metastasis completely. Biotin-labeled TN14003 can detect the CXCR4 receptors on cultured cells and paraffin-embedded patient tissue samples. They hypothesize that CXCR4 is required for breast cancer metastasis and can be used to detect metastasis because all metastasized tumors should have a high expression of CXCR4. Therefore, they plan to use CXCR4 antagonist as an imaging probe to detect primary tumors with high metastatic potential and their metastasis by non-invasive F18-Positron Emission Tomography (PET). This work is pursued in collaboration with Dr. Mark Goodman. In addition, they are in a process of developing small molecules against CXCR4/SDF-1 and new assays to screen drugs specific for CXCR4/SDF-1 interaction. The long-term outcome that we hope to achieve is the identification of a small molecule that will attenuate tumor metastasis in-vivo while demonstrating a sufficient pharmacokinetic and toxicological profile to merit advancement into human, clinical evaluation. Presently, we have identified several small molecules, including WZ40 which is currently the most advanced, that bind potently to CXCR4 and thus block the CXCR4/SDF-1 signaling process in collaboration with Drs Liotta/Snyder. We have followed this discovery by demonstrating that WZ40 inhibits tumor metastasis through this mechanistic pathway in both in vitro and in vivo studies. We now plan to build on these data and advance WZ40, or a mechanistically equivalent analog, toward human clinical evaluation. Early stage studies within 6 months will expand our current pool of active, CXCR4 antagonists, identify the most suitable lead for preclinical progression, and initiate advancement studies. A medicinal discovery program will be maintained throughout the screening and progression process in order to sustain a continuous escalation of novelty and efficacy. Specific screening studies that have been established for the selection process include in-vitro binding potency, a matrigel tissue penetration model, a calcium flux assay, anti-antiogenic efficacy, and pharmacokinetic stability screening. We have established and validated a number of in-vivo models of cancer metastasis that will be used to establish a proof of efficacy and dose dependency for our lead molecule. We will also study the specificity or cross-reactivity of our compounds against other chemokine recepors. Future aims will include advancement through preclinical development and IND application.

Patents Issued

Patents Pending

Active Grant Support: Federally Funded  

Active Grant Support: Private Foundation Funded  

Active Grant Support: Contracts  

Active Grant Support: Other  

Previous Grant Support: Federally Funded  

Previous Grant Support: Private Foundation Funded  

Previous Grant Support: Contracts  

Previous Grant Support: Other  

Clinical Service Contributions  

Formal Teaching: Medical Student  

Formal Teaching: Graduate Student  

08/2004 - Current Cancer Biology
01/2005 - Current Cancer Pharmacology

Formal Teaching: Residency/Training Program  

Formal Teaching: Other (Physician's Assistant, Physical Therapist, etc.)  

Supervisory Teaching: Ph.D. Students Directly Supervised  

Supervisory Teaching: Post-doctoral Fellows Directly Supervised  

Supervisory Teaching: Residency Program  

Supervisory Teaching: Other  

Lectureships, Seminar Invitations, Visiting Professorships  

Invitations to National/International Conferences  

Community Service  

Other Activities  

Bibliography: Research Articles  

Bibliography: Manuscripts  

Bibliography: Article Reviews  

Bibliography: Book Reviews  

Bibliography: Symposium Contributions  

Bibliography: Books Edited and Written  

Bibliography: Films and Training Videos  

Bibliography: Training Manuals  

Bibliography: Software and Computer Programs  

Bibliography: Published Abstracts  

Bibliography: Other Publications  

© 2014 Emory University
Last Update: 10/01/2014