Jorg Goronzy, M.D., Ph.D.
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Curriculum Vitae
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Name:
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Jorg J Goronzy
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Degree(s):
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Ph.D.
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M.D.
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Office Address:
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Woodruff Memorial Research Building, Suite 1003
101 Woodruff Circle
Atlanta, GA 30322
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Telephone:
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(404) 727-7310 (Office)
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Fax:
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Email Address:
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jgoronz@emory.edu (University)
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Current Primary Academic Appointments
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Current Joint & Secondary Appointments
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Current Clinical Appointments
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Current Administrative Appointments
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Previous Academic Appointments
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08/1999
- 12/2003
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Professor of Medicine
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Mayo Clinic
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Rochester, MN, USA
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Previous Clinical Appointments
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01/1990
- 12/2003
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Consultant, Department of Medicine, Division of Rheumatology
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Mayo Clinic
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Rochester, MN, USA
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Previous Administrative Appointments
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01/2001
- 12/2003
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Academic Director, Clinical Immunology and Immunotherapeutics Program
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Mayo Clinic
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Rochester, MN, USA
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Licensure & Board Certifications
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1988
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Ph.D., Medical Sciences
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University of Heidelberg
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Heidelberg, , Germany
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1979
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M.D., Medicine
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Aachen University
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Aachen, , Germany
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08/1984
- 05/1986
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Rheumatology Fellowship
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Stanford University Medical Center, Stanford, California, USA
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Military/Government Service
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National & International Committee Memberships
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State & Regional Committee Memberships
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Institutional Committee Memberships
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Editorships & Editorial Boards
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01/1999
- Current
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Arthritis Research and Therapy
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Associate Editor
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01/2002
- Current
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Autoimmunity
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Associate Editor
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07/2004
- Current
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Arthritis and Rheumatism
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Associate Editor
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01/1987
- Current
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Deutsche Gesellschaft für Immunologie
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Member
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01/1987
- Current
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American College of Rheumatology
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Member
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01/1988
- Current
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Deutsche Gesellschaft für Rheumatologie
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Member
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01/1994
- Current
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American Society for Clinical Investigation
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Member
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01/1996
- Current
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Molecular Medicine Society
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Member
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01/2001
- Current
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The Henry Kunkel Society
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Member
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01/2001
- Current
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The Clinical Immunology Society
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Member
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01/2001
- Current
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The American Association of Immunologists
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Member
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01/2002
- Current
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The Association of American Physicians
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Member
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Organization of National/International Conferences: Administrative Positions
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Organization of National/International Conferences: Sessions as Chair
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Active Grant Support: Federally Funded
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Active Grant Support: Private Foundation Funded
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Active Grant Support: Contracts
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Active Grant Support: Other
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Previous Grant Support: Federally Funded
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Previous Grant Support: Private Foundation Funded
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Previous Grant Support: Contracts
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Previous Grant Support: Other
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Clinical Service Contributions
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1. Diagnosis and treatment of inflammatory blood vessel diseases with particular experience in giant cell arteritis, polymyalgia rheumatica, and Takayasu's disease
2. Rheumatoid arthritis, extra-articular manifestations
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Formal Teaching: Medical Student
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Formal Teaching: Graduate Student
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Formal Teaching: Residency/Training Program
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Formal Teaching: Other (Physician's Assistant, Physical Therapist, etc.)
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Supervisory Teaching: Ph.D. Students Directly Supervised
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Supervisory Teaching: Post-doctoral Fellows Directly Supervised
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Supervisory Teaching: Residency Program
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Supervisory Teaching: Other
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Lectureships, Seminar Invitations, Visiting Professorships
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Invitations to National/International Conferences
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Bibliography: Research Articles
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Ma-Krupa W, Jeon M-S, Tedder TF, Goronzy JJ, Weyand CM. Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. (2004). J Exp Med vol. 199, 173-183.
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Goronzy JJ, Matteson EL, Fulbright JW, Warrington KJ, Crowson CS, Erlich HA, Reynolds RL, Swee RG, OFallon WM, Weyand CM. Prognostic markers for radiographic progression in early rheumatoid arthritis. (2004). Arthritis Rheum vol. 50, 43-54.
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Matteson EL, Weyand CM, Fulbright JW, Christianson TJH, McClelland RL, Goronzy JJ. How aggressive should initial therapy for rheumatoid arthritis be? Factors associated with response to non-aggressive DMARD treatment and perspective from a 2-yr open label trial. (2004). Rheumatology vol. 43, 619-625.
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Braun A, Takemura S, Vallejo AN, Goronzy JJ, Weyand CM. Lymphotoxin-²mediated stimulation of synoviocytes in rheumatoid arthritis. (2004). Arthritis Rheum vol. 50, 2140-2150.
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Lewis DE, Merched-Sauvage M, Goronzy JJ, Weyand CM, Vallejo AN. Tumor necrosis factor-± and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription. (2004). J Biol Chem vol. 279, 29130-2913.
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Snyder MR, Weyand CM, Goronzy JJ. The double life of NK receptors: Stimulation or costimulation. (2004). Trends in Immunology vol. 25, 25-32.
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Snyder MR, Lucas M, Vivier E, Weyand CM, Goronzy JJ. Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells. (2003). J Exp Med vol. 197, 437-449.
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Warrington KJ, Vallejo AN, Weyand CM, Goronzy JJ. CD28 loss in senescent CD4+ T Cells: Reversal by interleukin-12 stimulation. (2003). Blood vol. 101, 3543-3549.
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Nakajima T, Goek O, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. De novo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes. (2003). Circ Res vol. 93, 106-113.
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Schönland SO, Zimmer JK, Lopez-Benitez CM, Widmann T, Goronzy JJ, Weyand CM. Homeostatic control of T-cell generation in neonates. (2003). Blood vol. 102, 1428-1434.
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Vallejo AN, Yang H, Klimiuk PA, Weyand CM, Goronzy JJ. Synoviocyte-mediated expansion of inflammatory T-cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interaction. (2003). J Immunol vol. 171, 1732-1740.
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Schönland SO, Lopez C, Widmann T, Zimmer J, Bryl E, Goronzy JJ, Weyand CM. Premature telomeric loss in rheumatoid arthritis is genetically determined and involves lymphoid and myeloid cell lineages. (2003). Proc Natl Acad Sci vol. 100, 13471-1347.
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Weyand CM, Goronzy JJ. Giant-cell arteritis and polymyalgia rheumatica. (2003). Ann Intern Med vol. 139, 505-515.
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Weyand CM, Goronzy JJ. Mechanisms of disease: Medium- and large-vessel vasculitis. (2003). N Engl J Med vol. 349, 158-167.
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Borkowski A, Younge BR, Szweda L, Mock B, Björnsson J, Moeller K, Goronzy JJ, Weyand CM. Reactive nitrogen intermediates in giant cell arteritis: selective targeting of neocapillaries. (2002). Am J Pathol vol. 161, 1115-1123.
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Vallejo AN, Bryl E, Klarskov K, Naylor S, Weyand CM, Goronzy JJ. Molecular basis for the loss of CD28 expression in senescent T cells. (2002). J Biol Chem vol. 277, 46940-49.
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Snyder MR, Muegge L-O, Offord C, OFallon WM, Bajzer Z, Weyand CM, Goronzy JJ. Formation of the killer immunoglobulin-like receptor repertoire on CD4+CD28null T cells. (2002). J Immunol vol. 168, 2002.
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He X, Weyand CM, Goronzy JJ, Zhong W, Stuart JM. Bi-directional modulation of T cell-dependent antibody production by prostaglandin E2. (2002). Int Immunol vol. 14, 69-77.
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Weyand CM, Kaiser M, Yang H, Younge BR, Goronzy JJ. Therapeutic effects of acetylsalicylic acid in giant cell arteritis. (2002). Arthritis Rheum vol. 46, 457-466.
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Nakajima T, Schulte S, Warrington KJ, Kopecky SL, Frye RL, Goronzy JJ, Weyand CM. T-cell-mediated lysis of endothelial cells in acute coronary syndromes. (2002). Circulation vol. 105, 570-575.
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Kang YM, Zhang X, Wagner UG, Yang H, Beckenbaugh RD, Kurtin PJ, Goronzy JJ, Weyand CM. CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis. (2002). J Exp Med vol. 195, 1325-1336.
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Ma Krupa W, Dewan M, Jeon M-S, Kurtin PJ, Younge BR, Goronzy JJ, Weyand CM. Trapping of misdirected dendritic cells in the granulomatous lesions of giant cell arteritis. (2002). Am J Pathol vol. 161, 1815-1823.
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Bryl E, Vallejo AN, Weyand CM, Goronzy JJ. Down-regulation of CD28 expression by TNF-±. (2001). J Immunol vol. 167, 3231-3238.
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Goronzy JJ, Fulbright JW, Crowson CS, Poland GA, OFallon WM, Weyand CM. Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. (2001). J Virol vol. 75, 12182-87.
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Yen J-H, Moore BE, Nakajima T, Scholl D, Schaid DJ, Weyand CM, Goronzy JJ. Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. (2001). J Exp Med vol. 193, 1159-1167.
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Liuzzo G, Vallejo AN, Kopecky SL, Frye RL, Holmes DR, Goronzy JJ, Weyand CM. Molecular fingerprint of interferon-³ signaling in unstable angina. (2001). Circulation vol. 103, 1509-1514.
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Warrington KJ, Takemura S, Goronzy JJ, Weyand CM. CD4+,CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems. (2001). Arthritis Rheum vol. 44, 13-20.
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Vallejo AN, Weyand CM, Goronzy JJ. Functional disruption of the CD28 gene transcriptional initiator in senescent T cells. (2001). J Biol Chem vol. 276, 2565-2570.
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Takemura S, Braun A, Crowson C, Kurtin PJ, Cofield RH, OFallon WM, Goronzy JJ, Weyand CM. Lymphoid neogenesis in rheumatoid synovitis. (2001). J Immunol vol. 167, 1072-1080.
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Takemura S, Klimiuk PA, Braun A, Goronzy JJ, Weyand CM. T cell activation in rheumatoid synovium is B cell dependent. (2001). J Immunol vol. 167, 4710-4718.
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Goronzy JJ, Weyand CM. Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis. (2001). Trends in Immunol vol. 22, 251-255.
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19. Namekawa T, Snyder MR, Yen JH, Goehring BE, Leibson PJ, Weyand CM, Goronzy JJ. Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in rheumatoid arthritis. (2000). J Immunol vol. 165, 1138-1145.
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Koetz K, Bryl E, Spickschen K, OFallon WM, Goronzy JJ, Weyand CM. T cell homeostasis in patients with rheumatoid arthritis. (2000). Proc Natl Acad Sci USA vol. 97, 9203-9308.
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Vallejo AN, Mügge, LO, Klimiuk PA, Weyand CM, Goronzy JJ. Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cells. (2000). J Immunol vol. 164, 2947-2954.
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Vallejo AN, Schirmer M, Weyand CM, Goronzy JJ. Clonality and longevity of CD4+CD28null T cells is associated with defects in apoptotic pathways. (2000). J Immunol vol. 165, 6301-6307.
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Rittner HL, Hafner V, Klimiuk PA, Szweda LI, Goronzy JJ, Weyand CM. Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis. (1999). J Clin Invest vol. 103, 1007-1013.
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16. Kaiser M, Younge B, Björnsson J, Weyand CM, Goronzy JJ. Formation of new vasa vasorum in vasculitis: Production of angiogenic cytokines by multinucleated giant cells. (1999). Am J Pathol vol. 155, 765-774.
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17. Vallejo AN, Brandes JC, Weyand CM, Goronzy JJ. Modulation of CD28 expression: Distinct regulatory pathways during activation and replicative senescence. (1999). J Immunol vol. 162, 6572-6579.
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Vallejo A, Nestel AR, Schirmer M, Weyand CM, Goronzy JJ. Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene specific nuclear factor binding activity. (1998). J Biol Chem vol. 273, 8119-8129.
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Schirmer M, Weyand CM, Goronzy JJ. Resistance to apoptosis and elevated expression of BcL-2 in clonally expanded CD4+ CD28- T cells from rheumatoid arthritis patients. (1998). J Immunol vol. 161, 1018-1025.
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Wagner UG, Koetz K, Weyand CM, Goronzy JJ. Perturbation of the T cell repertoire in rheumatoid arthritis. (1998). Proc Natl Acad Sci USA vol. 95, 14447-52.
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Wagner U, Kurtin P, Wahner A, Brackertz M, Berry D, Goronzy JJ, Weyand CM. The role of CD8+ CD40L+ T cells in the formation of germinal centers in rheumatoid synovitis. (1998). J Immunol vol. 161, 6390-6397.
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Brack A, Rittner HL, Younge BR, Kaltschmidt C, Weyand CM, Goronzy JJ. Glucocorticoid mediated repression of cytokine gene transcription in human arteritis-SCID chimeras. (1997). J Clin Invest vol. 99, 2842-2850.
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Martens PB, Goronzy JJ, Schaid DJ, Weyand CM. Expansion of unusual CD4+ T cells in severe rheumatoid arthritis. (1997). Arthritis Rheum vol. 40, 1106-1114.
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Weyand CM, Wagner AD, Björnsson J, Goronzy JJ. Correlation of topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis. (1996). J Clin Invest vol. 98, 1642-1649.
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Schmidt D, Goronzy JJ, Weyand CM. CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. (1996). J Clin Invest vol. 97, 2027-2037.
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Walser-Kuntz DR, Weyand CM, Weaver AJ, OFallon WM, Goronzy JJ. Mechanisms underlying the formation of the T cell receptor repertoire in rheumatoid arthritis. (1995). Immunity vol. 2, 597-605.
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Weyand CM, McCarthy TG, Goronzy JJ. Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis. (1995). J Clin Invest vol. 95, 2120-2126.
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Weyand CM, Hicok KC, Hunder GG, Goronzy JJ. Tissue cytokine patterns in polymyalgia rheumatica and giant cell arteritis. (1994). Ann Intern Med vol. 121, 484-491.
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Goronzy JJ, Bartz-Bazzanella P, Hu W, Jendro MC, Walser-Kuntz DR, Weyand CM. Dominant clonotypes in the repertoire of peripheral CD4+ T cells in rheumatoid arthritis. (1994). J Clin Invest vol. 94, 2068-2076.
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3. Wagner AD, Goronzy JJ, Weyand CM. Functional profile of tissue infiltrating and circulating CD68+ cells in giant cell arteritis. Evidence for two components of the disease. (1994). J Clin Invest vol. 94, 1134-1140.
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Weyand CM, Schönberger J, Oppitz U, Hunder NNH, Hicok KC, Goronzy JJ. Distinct vascular lesions in giant cell arteritis share identical T cell clonotypes. (1994). J Exp Med vol. 179, 951-960.
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Weyand CM, Xie C, Goronzy JJ. Homozygosity for the HLA-DRB1 allele selects for extra-articular manifestations in rheumatoid arthritis. (1992). J Clin Invest vol. 89, 2033-2039.
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Bibliography: Manuscripts
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Bibliography: Article Reviews
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Bibliography: Book Reviews
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Bibliography: Symposium Contributions
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Bibliography: Books Edited and Written
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Goronzy JJ, Weyand CM. (2000). Rheumatoid Arthritis. New York:Karger.
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Bibliography: Films and Training Videos
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Bibliography: Training Manuals
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Bibliography: Software and Computer Programs
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Bibliography: Published Abstracts
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Bibliography: Other Publications
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