Current Status: GRAD
Graduate Department: Biomedical Engineering
Previous Education:S.B. Nuclear Science and Engineering, S.M. Nuclear Science and Engineering, Massachusetts Institute of Technology;
Advisor(s): Thomas Barker, PhD
Hometown: Nashville, TN
Board games, bow ties, beer, bromance, being fed delicious things & (b)reading and anticlimactic alliteration.
Mechano-sensing matures: mechanical gene therapies for pulmonary fibrosis
Fibroblasts (though more generally all cells) have finely tuned mechano-sensing pathways that are essential for homeostasis and development and perverted in pathologies like fibrosis. In pulmonary fibrosis, specifically, the stiff matrix and the fibroblast are locked in a viscious feed-forward loop, wherein matrix stiffness drives fibroblast activation which drives matrix stiffness. Using a conserved mechano-sensing pathway in fibroblasts, we hope to turn the invert this paradigm on its head and use gene circuits to sense and respond specifically to areas of matrix stiffness.