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Brian Robinson

Current Status: Alumni

Graduate Department: Biochemistry, Cell and Developmental Biology

Advisor(s): Kenneth H. Moberg, PhD;


Patterned growth is fundamental to proper metazoan development, and deregulated growth is implicated in human diseases including cancer. In the Moberg lab, we use the fruit fly Drosophila melanogastor as a model system to identify growth regulatory mechanisms in developing epithelia. Myefforts focused on the analysis of the Hippo/Mst-2 pathway, a well-conserved growth regulatory pathway that prevents inappropriate tissue growth in flies and suppresses tumor formation in humans. In particular, my work elaborated a novel growth-regulatory role for the apicobasal polarity factor Crumbs in regulating Hippo/Mst-2 signaling. In so doing, this work defined a novel mechanism whereby apicobasal polarity factors can influence growth programs, and offered insight to how deregulation of polarity programs can promote tumor formation in metazoans.

Graduation Year: 2013

Residency: Pathology, Emory University

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