Steve Harris

Current Status: Alumni

Graduate Department: Biomedical Engineering

Other Degrees: B.E., Vanderbilt University;  

Advisor(s): Xiaoping Hu, PhD;

Hometown: Eugene, OR

Hobbies

gardening, hiking, camping, baking, playing violin and piano, computer programming, reading, history, soccer, travel

Research

Iron oxide nanoparticles are of great clinical and research interest for their ability to produce contrast in MRI images. When these nanoparticles are targeted to a specific molecular environment, they may allow for the earlier diagnosis of diseases such as cancer and atherosclerosis. My work focuses on developing better methods for imaging the nanoparticles with MRI that are specific to the molecular environment surrounding the nanoparticle. Using an adiabatic preparation pulse, we have developed a technique that produces a linearly increasing MRI contrast with increasing iron oxide nanoparticle concentration. Improving the detection sensitivity and specificity not only improve nanoparticle localization within the image but also allow for quantitative molecular imaging. We are currently applying this technique to cellular and molecular MRI studies. Iron oxide nanoparticles are of great clinical and research interest for their ability to produce contrast in MRI images. When these nanoparticles are targeted to a specific molecular environment, they may allow for the earlier diagnosis of diseases such as cancer and atherosclerosis. My work focuses on developing better methods for imaging the nanoparticles with MRI that are specific to the molecular environment surrounding the nanoparticle. Using an adiabatic preparation pulse, we have developed a technique that produces a linearly increasing MRI contrast with increasing iron oxide nanoparticle concentration. Improving the detection sensitivity and specificity not only improve nanoparticle localization within the image but also allow for quantitative molecular imaging. We are currently applying this technique to cellular and molecular MRI studies.

Graduation Year: 2013

Residency: Radiology-Diagnostic, Duke University

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