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Mild Cognitive Impairment: Research Studies

BAN2401

Allan Levey, MD, PhD

For more information about this research study, please call Gail Schwartz at 404-728-6395 or email gschwar@emory.edu.

Link to study website »


Atomoxetine Clinical Trial:

Allan Levey, MD, PhD
Director Emory Alzheimer's Disease Research Center, Chair, Emory University Department of Neurology

The purpose of this study is to find out if atomoxetine causes a change in the biologic markers (substances that may indicate the presence of a disease) in the cerebrospinal fluid (CSF) of participants diagnosed with Mild Cognitive Impairment (MCI). In this research study, the spinal fluid of subjects with MCI who take atomoxetine will be compared to spinal fluid of those who take capsules containing inactive material, also known as placebo. At the six-month timepoint, subjects who were taking placebo during the first six months will be placed on active study medication, and those who received active study medication will be reassigned to placebo.

This study will also evaluate if the drug is safe and well-tolerated. Additionally, information will be gathered to identify the dose of atomoxetine that is most beneficial, and how taking this medication affects thinking and behavior, as well as imaging and blood biomarkers. The results of this research will help determine if atomoxetine alters signs of inflammation and other biomarkers associated with Alzheimer's disease.


For more information about this research study, please call Lavezza Zanders at 404-728-6392 or email lzander@emory.edu.

Link to study website »


Alzheimer's Disease Neuroimaging Initiative - GO

Allan Levey, MD, PhD
Director, Emory Alzheimer's Disease Research Center
Emory University Department of Neurology

In 2004 the Alzheimer’s Disease Neuroimaging Initiative (ADNI) began recruiting subjects into a five year study to identify biomarkers that were the earliest indicators of disease and that could most accurately track disease progression.  Eight hundred volunteers were recruited 25% without memory complaints, 50% with Mild Cognitive Impairment and 25 % with a diagnosis of Alzheimer’s disease.  The study was one of the largest of its kind supported by the National Institute of Aging in an innovative partnership with private industry.  Study volunteers were followed every 6-12 months with detailed assessments of memory and other thinking abilities along with detailed brain imaging and collection of other biomarkers such as cerebrospinal fluid. 

The project has proven so successful that in 2009 the National Institute of Aging funded an expansion of the study called ADNI Grand Opportunities (ADNI-GO) to include individuals with even earlier stages of Mild Cognitive Impairment.  This past summer it was announced that the National Institute on Aging would be funding the second five year phase of ADNI now referred to as ADNI-2.  This phase of the study will continue to follow the original ADNI subjects enrolled in 2004 but will also allow for recruitment of a new cohort of 550 new volunteers to continue the research efforts. 

For more information about this research study, please call Janet Cellar at 404-728-6453 or email jcellar@emory.edu.


Cognitive Rehabilitation of Memory in Mild Cognitive Impairment

Ben Hampstead, PhD
Assistant Professor, School of Medicine: Department of Rehabilitation

Link to study flyer »

Identifying rehabilitation strategies that will help people with mild cognitive impairment function better in their everyday life is the goal of this Cognitive Rehabilitation study.   Using MRI, Ben Hampstead, Phd. is comparing the patterns of brain activity before and after people receive cognitive rehabilitation.  The study requires 6-8 visits and will include 3 training sessions and two MRI scans.

For more information about this research study, please call Justin Hartley at 404-712-0936 or email jhartl3@emory.edu.

For more information about this research study, please call Casey Bowden at 404-712-4321 or email ebowden@emory.edu.


Cognitive Aging Project

James Herndon, PhD
Yerkes National Primate Research Center

The broad aim of the study is to examine how the aging process differentially affects females of three closely related primate species: humans, chimpanzees, and the rhesus monkey. Women who participate in the study undergo magnetic resonance (MRI) scanning, in addition to annual testing on a battery of tests designed to evaluate memory and other cognitive abilities.  Healthy middle-aged and elderly women, as well as women that have been diagnosed with Mild Cognitive Impairment (MCI) or early Alzheimer’s disease will be enrolled in this research study.

For more information about this research study, please call CeeCee Manzanares at 404-727-9324 or email cmanzan@emory.edu.


Memory Training in Mild Cognitive Impairment

Melanie Greenaway, PhD
Emory University Department of Neurology

Link to study flyer »

This trial is no longer enrolling.

Persons with a diagnosis of Mild Cognitive Impairment (MCI) are often interested in actively trying to manage or compensate for their memory difficulties in a way that can help them now and into the future.  New treatment options such as keeping memory notebooks or doing mental exercises on the computer are being investigated. Both the person with MCI and a program partner (a spouse, relative, or friend) participate in the research program. Participants will be assigned based on chance to learn how to use memory notebooks or do brain fitness computer activities either over 10 days or a 6 week format. All participants also will take part in educational sessions with other individuals diagnosed with MCI and their program partners.

For more information about this research study, please call Noah Duncan at 404-728-6544.


Emory Alzheimer's Disease Research Center Honor Research Registry

James Lah, MD, PhD
Clinical Core Leader, Emory Alzheimer's Disease Research Center

Felicia Goldstein, PhD
Clinical Core Co-Leader, Emory Alzheimer's Disease Research Center

Link to study flyer »

The purpose of Honor is to have a group of volunteers who want to participate in future research studies on memory & thinking.    By joining Honor you will learn about new research studies that are seeking volunteers.  You will also receive our newsletter and invitations to educational events. 

All Honor volunteers must have a “study partner” accompany them to their research visit.  Your study partner will be asked questions about your memory and thinking.  They will also be asked about your day to day functioning.  A study partner is someone who has at least 10 hours of contact with you each week.

For more information about this research study, please call Letheshia Husbands at 404-728-6950 or email lhusban@emory.edu .


Registry for Remembrance

Monica Parker, MD
Assistant Professor, Emory University School of Medicine

Link to study flyer »

The Registry for Remembrance (Remembrance study) is a special academic community partnership to educate and recruit African Americans for long term research participation at the Emory Alzheimer’s Disease Research Center (ADRC). As a Remembrance study volunteer, you will participate in a research study on memory. You will be informed of new research studies at the ADRC and have an opportunity to participate in research that focuses on understanding conditions that affect memory and thinking. You will also be on our mailing list to receive the ADRC’s bi-annual newsletter to be informed of educational events. For this research study, you will need to identify a person who can inform us about your memory and day to day functioning. This study informant should know you well enough to be able to answer questions about changes in your memory or ability to perform independent living functions.

For more information about this research study, please call Letheshia Husbands at 404-728-6950 or email lhusban@emory.edu .